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Sökning: WFRF:(O'Toole R) > (2010-2014) > Composition and ene...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005681naa a2200445 4500
001oai:DiVA.org:oru-65934
003SwePub
008180321s2010 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-659342 URI
0247 a https://doi.org/10.1136/gut.2010.2156652 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Murphy, E. F.u Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Alimentary Health Ltd, Cork, Ireland4 aut
2451 0a Composition and energy harvesting capacity of the gut microbiota :b relationship to diet, obesity and time in mouse models
264 c 2010-10-06
264 1b BMJ Publishing Group Ltd,c 2010
338 a print2 rdacarrier
500 a Funding Agencies:Teagasc (an Agency of the Irish Government Department of Agriculture, Fisheries and Food)Science Foundation IrelandAlimentary Health Ltd
520 a BACKGROUND AND AIMS: Increased efficiency of energy harvest, due to alterations in the gut microbiota (increased Firmicutes and decreased Bacteroidetes), has been implicated in obesity in mice and humans. However, a causal relationship is unproven and contributory variables include diet, genetics and age. Therefore, we explored the effect of a high-fat (HF) diet and genetically determined obesity (ob/ob) for changes in microbiota and energy harvesting capacity over time.METHODS: Seven-week-old male ob/ob mice were fed a low-fat diet and wild-type mice were fed either a low-fat diet or a HF-diet for 8 weeks (n=8/group). They were assessed at 7, 11 and 15 weeks of age for: fat and lean body mass (by NMR); faecal and caecal short-chain fatty acids (SCFA, by gas chromatography); faecal energy content (by bomb calorimetry) and microbial composition (by metagenomic pyrosequencing).RESULTS: A progressive increase in Firmicutes was confirmed in both HF-fed and ob/ob mice reaching statistical significance in the former, but this phylum was unchanged over time in the lean controls. Reductions in Bacteroidetes were also found in ob/ob mice. However, changes in the microbiota were dissociated from markers of energy harvest. Thus, although the faecal energy in the ob/ob mice was significantly decreased at 7 weeks, and caecal SCFA increased, these did not persist and faecal acetate diminished over time in both ob/ob and HF-fed mice, but not in lean controls. Furthermore, the proportion of the major phyla did not correlate with energy harvest markers.CONCLUSION: The relationship between the microbial composition and energy harvesting capacity is more complex than previously considered. While compositional changes in the faecal microbiota were confirmed, this was primarily a feature of high-fat feeding rather than genetically induced obesity. In addition, changes in the proportions of the major phyla were unrelated to markers of energy harvest which changed over time. The possibility of microbial adaptation to diet and time should be considered in future studies.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
7001 a Cotter, P. D.u Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, Ireland4 aut
7001 a Healy, S.u Alimentary Health Ltd, Cork, Ireland4 aut
7001 a Marques, Tatiana M.,d 1980-u Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, Ireland4 aut0 (Swepub:oru)tams
7001 a O'Sullivan, O.u Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, Ireland4 aut
7001 a Fouhy, F.u Teagasc Moorepark Food Research Centre, Fermoy, Ireland4 aut
7001 a Clarke, S. F.u Teagasc Moorepark Food Research Centre, Fermoy, Ireland; Department of Microbiology, University College Cork, Cork, Ireland4 aut
7001 a O'Toole, P. W.u Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Department of Microbiology, University College Cork, Cork, Ireland4 aut
7001 a Quigley, E. M.u Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland4 aut
7001 a Stanton, C.u Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, Ireland4 aut
7001 a Ross, P. R.u Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, Ireland4 aut
7001 a O'Doherty, R. M.u Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, USA4 aut
7001 a Shanahan, F.u Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland4 aut
7102 a Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Alimentary Health Ltd, Cork, Irelandb Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, Ireland4 org
7730 t Gutd : BMJ Publishing Group Ltdg 59:12, s. 1635-42q 59:12<1635-42x 0017-5749x 1468-3288
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-65934
8564 8u https://doi.org/10.1136/gut.2010.215665

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