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Presence of microorganisms in children with pharyngotonsillitis and healthy controls: a prospective study in primary healthcare

Pallon, Jon (author)
Lund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups,Region Kronoberg,Lund Univ, Sweden; Dept Res & Dev, Sweden; Inst Kansliet Klin Vetenskaper, Sweden
Sundqvist, Martin, 1974- (author)
Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Laboratory Medicin,Orebro Univ, Sweden
Rööst, Mattias (author)
Lund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups,Region Kronoberg,Lund Univ, Sweden; Dept Res & Dev, Sweden
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Danielsson, P. (author)
Cityläkarna Primary Healthcare Centre, Region Kalmar County, Kalmar, Sweden,Kalmar County Hospital,Citylakarna Primary Healthcare Ctr, Sweden
Neumark, T. (author)
Region Kalmar County, Kalmar, Sweden,Kalmar County Hospital
Skovbjerg, Susann, 1973 (author)
University of Gothenburg,Gothenburg University,Göteborgs universitet,CARe - Centrum för antibiotikaresistensforskning,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Centre for antibiotic resistance research, CARe,Institute of Biomedicine, Department of Infectious Medicine,Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Microbiology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden; Centre for Antibiotic Resistance Research (CARe), University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
Svedin, J. (author)
Anderslöv Primary Healthcare Centre, Region Skåne, Anderslöv, Sweden,Anderslov Primary Healthcare Ctr, Sweden
Hedin, Katarina (author)
Linköpings universitet,Linköping University,Lund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Lund Univ, Sweden
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 (creator_code:org_t)
2021-03-08
2021
English.
In: Infection. - : Springer Science and Business Media LLC. - 0300-8126 .- 1439-0973. ; 49:4, s. 715-724
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Purpose Most studies on paediatric pharyngotonsillitis focus on group A streptococci. This study, however, analyses a broad spectrum of bacteria and viruses related to paediatric pharyngotonsillitis and evaluates their associated clinical symptoms and courses. Methods This observational prospective study in primary healthcare includes 77 children aged < 15 with a sore throat and 34 asymptomatic children, all of whom were sampled from the tonsils with an E-swab(R) for analysis with culture and PCR for 14 bacteria and 15 viruses. Patients were evaluated clinically, and their symptoms recorded in diaries for 10 days. Participants were followed up for 3 months by reviewing medical records. Results A pathogen was detected in 86% of patients and in 71% of controls (P = 0.06). Bacteria were found in 69% of patients and 59% of controls (P = 0.3), and viruses in 36% and 26%, respectively (P = 0.3). Group A streptococci was the most common finding, with a prevalence of 49% and 32%, respectively (P = 0.1). Clinical signs were not useful for distinguishing pathogens. None of the controls and 16% of the patients reconsulted for a sore throat within 3 months. Conclusion Bacteria were more common than viruses in both study groups. The high rate of pathogens in asymptomatic children interferes with diagnoses based on aetiology.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Keyword

Pharyngotonsillitis
Aetiology
Children
Primary healthcare
PCR
Prospective
Infectious Diseases
Aetiology

Publication and Content Type

ref (subject category)
art (subject category)

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