WFRF:(Palmqvist Lars 1965)
Sökning: WFRF:(Palmqvist Lars 1965) > Response to cAMP le...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05542naa a2200865 4500 | |
| 001 | oai:gup.ub.gu.se/215786 | |
| 003 | SwePub | |
| 008 | 240528s1994 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2157862 URI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Fåhraeus, R4 aut |
| 245 | 1 0 | a Response to cAMP levels of the Epstein-Barr virus EBNA2-inducible LMP1 oncogene and EBNA2 inhibition of a PP1-like activity. |
| 264 | 1 | c 1994 |
| 520 | a The expression of the Epstein-Barr virus LMP1 oncogene is regulated by viral and non-viral factors in a tissue dependent fashion. The virus encoded transcription factor EBNA2 induces its expression in human B-cells. However, this induction also requires the contribution of cellular and/or other viral factors. In nasopharyngeal carcinoma cells and in cells from Hodgkin's lymphoma, LMP1 gene transcription is independent of viral products. Here we show that the effect of a factor binding to a cAMP responsive-like element (CRE) in the LMP1 gene transcription regulatory sequence (LRS) is essential for efficient promoter activity in the DG75 B-cell line and that elevation of cAMP levels in the cells induces LRS-derived CAT activity in a CRE dependent fashion. Incubation of two EBV-immortalized B-cell lines expressing endogenous EBNA2A with 8-Br cAMP increased the levels of the latency associated 66 kDa LMP1 within 2 h. Interestingly, LMP1 expression in DG75 cells conferred resistance to the inhibitory effect of 8-Br cAMP on cell proliferation. The protein phosphatase 1 and 2A (PP1 and PP2A, respectively) inhibitor okadaic acid also stimulated LRS-CAT activity in DG75 cells. EBNA2A from an EBV-immortalized B-cell line co-immunopurified with a PP1-like protein. An EBNA2A fragment spanning residues 324-436 fused to the GST protein specifically rescued a PP1/PP2A-like component from DG75 cell extracts. This GST-EBNA2A fusion product inhibited a PP1-like activity in nuclear extracts from these cells. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
| 653 | a 8-Bromo Cyclic Adenosine Monophosphate | |
| 653 | a pharmacology | |
| 653 | a Antigens | |
| 653 | a Viral | |
| 653 | a genetics | |
| 653 | a metabolism | |
| 653 | a B-Lymphocytes | |
| 653 | a metabolism | |
| 653 | a virology | |
| 653 | a Base Sequence | |
| 653 | a Burkitt Lymphoma | |
| 653 | a metabolism | |
| 653 | a virology | |
| 653 | a Cell Division | |
| 653 | a Cell Nucleus | |
| 653 | a metabolism | |
| 653 | a Cyclic AMP | |
| 653 | a pharmacology | |
| 653 | a Epstein-Barr Virus Nuclear Antigens | |
| 653 | a Ethers | |
| 653 | a Cyclic | |
| 653 | a pharmacology | |
| 653 | a Herpesvirus 4 | |
| 653 | a Human | |
| 653 | a drug effects | |
| 653 | a genetics | |
| 653 | a Humans | |
| 653 | a Molecular Sequence Data | |
| 653 | a Okadaic Acid | |
| 653 | a Oncogenes | |
| 653 | a genetics | |
| 653 | a Phosphoprotein Phosphatases | |
| 653 | a metabolism | |
| 653 | a Protein Phosphatase 1 | |
| 653 | a Regulatory Sequences | |
| 653 | a Nucleic Acid | |
| 653 | a genetics | |
| 653 | a Transcription | |
| 653 | a Genetic | |
| 653 | a Tumor Cells | |
| 653 | a Cultured | |
| 653 | a Viral Matrix Proteins | |
| 653 | a genetics | |
| 653 | a Virus Latency | |
| 653 | a genetics | |
| 700 | 1 | a Palmqvist, Lars,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine4 aut0 (Swepub:gu)xpalla |
| 700 | 1 | a Nerstedt, Annika,d 1960u Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine4 aut0 (Swepub:gu)xneran |
| 700 | 1 | a Farzad, Siminu Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine4 aut |
| 700 | 1 | a Rymo, Lars,d 1940u Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine4 aut0 (Swepub:gu)xrymla |
| 700 | 1 | a Laín, Soniau Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin4 org |
| 773 | 0 | t The EMBO journalg 13:24, s. 6041-51q 13:24<6041-51x 0261-4189 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/215786 |
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