Sökning: WFRF:(Ragagnin Gianna) > Allopregnanolone in...
Fältnamn | Indikatorer | Metadata |
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000 | 03868naa a2200517 4500 | |
001 | oai:DiVA.org:umu-145173 | |
003 | SwePub | |
008 | 180312s2018 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1451732 URI |
024 | 7 | a https://doi.org/10.1016/j.yfrne.2017.07.0022 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a for2 swepub-publicationtype |
100 | 1 | a Holmberg, Ellinoru Umeå universitet,Obstetrik och gynekologi4 aut |
245 | 1 0 | a Allopregnanolone involvement in feeding regulation, overeating and obesity |
264 | 1 | b Academic Press,c 2018 |
338 | a electronic2 rdacarrier | |
520 | a Obesity is strongly associated with ill health, primarily caused by consumption of excessive calories, and promoted (inter alia) by gamma-amino-butyric-acid (GABA) stimulating food intake by activating GABA(A) receptors (primarily with alpha 3 and alpha 2 subunits) in the hypothalamic arcuate nucleus and paraventricular nucleus. Allopregnanolone is a potent positive GABAA receptor modulating steroid (GAMS). As reviewed here, elevated allopregnanolone levels are associated with increases in food intake, preferences for energy-rich food, and obesity in humans and other mammals. In women with polycystic ovarian disease, high serum allopregnanolone concentrations are linked to uncontrolled eating, and perturbed sensitivity to allopregnanolone. Increases in weight during pregnancy also correlate with increases in allopregnanolone levels. Moreover, Prader-Willis syndrome is associated with massive overeating, absence of a GABA(A) receptor (with compensatory > 12-, > 5- and > 1.5-fold increases in alpha 4, gamma 2, and alpha 1, alpha 3 subunits), and increases in the alpha 4, beta x, delta receptor subtype, which is highly sensitive to allopregnanolone. GABA and positive GABA-A receptor modulating steroids like allopregnanolone stimulates food intake and weight gain. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
653 | a Allopregnanolone | |
653 | a GABA | |
653 | a GABA(A) receptor | |
653 | a Satiety | |
653 | a Hunger | |
653 | a Obesity | |
653 | a Overeating | |
700 | 1 | a Sjöstedt, J.u Umeå universitet,Obstetrik och gynekologi4 aut |
700 | 1 | a Malinina, E.u Umeå universitet,Obstetrik och gynekologi4 aut |
700 | 1 | a Johansson, Majau Umeå universitet,Obstetrik och gynekologi4 aut0 (Swepub:umu)injo0002 |
700 | 1 | a Turkmen, Sahruhu Umeå universitet,Obstetrik och gynekologi4 aut0 (Swepub:umu)satu0001 |
700 | 1 | a Ragagnin, Giannau Umeå universitet,Obstetrik och gynekologi4 aut |
700 | 1 | a Lundqvist, Anetteu Umeå universitet,Obstetrik och gynekologi4 aut |
700 | 1 | a Löfgren, Matsu Umeå universitet,Obstetrik och gynekologi4 aut0 (Swepub:umu)malo0003 |
700 | 1 | a Jaukkuri, L.u Umeå universitet,Obstetrik och gynekologi4 aut |
700 | 1 | a Bixo, Marieu Umeå universitet,Obstetrik och gynekologi4 aut0 (Swepub:umu)mabi0001 |
700 | 1 | a Bäckström, Torbjörnu Umeå universitet,Obstetrik och gynekologi4 aut0 (Swepub:umu)toba0001 |
710 | 2 | a Umeå universitetb Obstetrik och gynekologi4 org |
773 | 0 | t Frontiers in neuroendocrinology (Print)d : Academic Pressg 48, s. 70-77q 48<70-77x 0091-3022x 1095-6808 |
856 | 4 | u https://doi.org/10.1016/j.yfrne.2017.07.002y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1189681/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://doi.org/10.1016/j.yfrne.2017.07.002 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-145173 |
856 | 4 8 | u https://doi.org/10.1016/j.yfrne.2017.07.002 |
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