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Hypodiploidy has unfavorable impact on survival in pediatric acute myeloid leukemia : An I-BFM Study Group collaboration

Borg Hammer, Anne Sofie (författare)
Department of Pediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
Løvvik Juul-Dam, Kristian (författare)
Department of Pediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
Damgaard Sandahl, Julie (författare)
Department of Pediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Abrahamsson, Jonas (författare)
Children's Cancer Center, Queen Silvia's Children's Hospital, Göteborg, Sweden
Czogala, Malgorzata (författare)
Department of Pediatric Oncology and Hematology, Jagiellonian University Medical College, Institute of Pediatrics, Krakow, Poland
Delabesse, Emmanuelle (författare)
Toulouse-Oncopole, Laboratoire d'Hématologie Secteur Génétique des Hémopathies, Toulouse, France
Haltrich, Iren (författare)
2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
Jahnukainen, Kirsi (författare)
New Children's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Kolb, E. Anders (författare)
Nemours/Alfred I. DuPont Hospital for Children, DE, Wilmington, United States
Kovács, Gábor (författare)
2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
Leverger, Guy (författare)
Hopital Armand Trousseau, Assistance Publique-Hopitaux de Paris, Service d'Hematologie et d'Oncologie Pediatrique, Paris, France
Locatelli, Franco (författare)
Department of Pediatric Haematology/Oncology and Cell and Gene Therapy, IRCCS Ospedale Pediatrico Bambino Gesù, Catholic University of the Sacred Heart, Rome, Italy
Masetti, Riccardo (författare)
Dipartimento di Scienze Mediche e Chirurgiche, Pediatric Oncology and Hematology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
Norén-Nyström, Ulrika (författare)
Umeå universitet,Pediatrik
Raimondi, Susana C. (författare)
St Jude Children's Research Hospital, TN, Memphis, United States
Rasche, Mareike (författare)
Department of Pediatric Hematology-Oncology, Pediatrics III, University Hospital of Essen, Essen, Germany
Reinhardt, Dirk (författare)
Department of Pediatric Hematology-Oncology, Pediatrics III, University Hospital of Essen, Essen, Germany
Taki, Tomohiko (författare)
Faculty of Health Sciences, Laboratory of Clinical Hematology, Department of Medical Technology, Kyorin University, Mitaka, Japan
Tomizawa, Daisuke (författare)
Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan
Zeller, Bernward (författare)
Department of Pediatric Hematology and Oncology, Oslo University Hospital, Oslo, Norway
Hasle, Henrik (författare)
Department of Pediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
Kjeldsen, Eigil (författare)
Department of Hematology, Hemodiagnostic Laboratory, Aarhus University Hospital, Aarhus, Denmark
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 (creator_code:org_t)
2023-03-20
2023
Engelska.
Ingår i: Blood Advances. - : American Society of Hematology. - 2473-9529 .- 2473-9537. ; 7:6, s. 1045-1055
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Hypodiploidy, defined as modal numbers (MNs) 45 or lower, has not been independently investigated in pediatric acute myeloid leukemia (AML) but is a well-described high-risk factor in pediatric acute lymphoblastic leukemia. We aimed to characterize and study the prognostic impact of hypodiploidy in pediatric AML. In this retrospective cohort study, we included children below 18 years of age with de novo AML and a hypodiploid karyotype diagnosed from 2000 to 2015 in 14 childhood AML groups from the International Berlin-Frankfurt-Münster (I-BFM) framework. Exclusion criteria comprised constitutional hypodiploidy, monosomy 7, composite karyotype, and t(8;21) with concurring sex chromosome loss. Hypodiploidy occurred in 81 patients (1.3%) with MNs, 45 (n = 66); 44 (n = 10) and 43 (n = 5). The most frequently lost chromosomes were chromosome 9 and sex chromosomes. Five-year event-free survival (EFS) and overall survival (OS) were 34% and 52%, respectively, for the hypodiploid cohort. Children with MN≤44 (n = 15) had inferior EFS (21%) and OS (33%) compared with children with MN = 45 (n = 66; EFS, 37%; OS, 56%). Adjusted hazard ratios (HRs) were 4.9 (P = .001) and 6.1 (P = .003). Monosomal karyotype or monosomy 9 had particular poor OS (43% and 15%, respectively). Allogeneic stem cell transplantation (SCT) in first complete remission (CR1) (n = 18) did not mitigate the unfavorable outcome of hypodiploidy (adjusted HR for OS was 1.5; P = .42). We identified pediatric hypodiploid AML as a rare subgroup with an inferior prognosis even in the patients treated with SCT in CR1.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Pediatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Pediatrics (hsv//eng)

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