β-Amyloid and tau biomarkers and clinical phenotype in dementia with Lewy bodies

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Sökning: WFRF:(Schwarz Daniel F.) > (2020-2024) > β-Amyloid and tau b...

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Fältnamn	Indikatorer	Metadata
000		05505naa a2200649 4500
001		oai:lup.lub.lu.se:71b0c389-e1dd-4676-bb65-3c5663b86ecd
003		SwePub
008		210115s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:145678535
024	7	a https://lup.lub.lu.se/record/71b0c389-e1dd-4676-bb65-3c5663b86ecd2 URI
024	7	a https://doi.org/10.1212/WNL.00000000000109432 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1456785352 URI
040		a (SwePub)lud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Ferreira, Danielu Karolinska Institutet,Karolinska Institute,Mayo Clinic Minnesota4 aut
245	1 0	a β-Amyloid and tau biomarkers and clinical phenotype in dementia with Lewy bodies
264	1	c 2020
520		a OBJECTIVE: In a multicenter cohort of probable dementia with Lewy bodies (DLB), we tested the hypothesis that β-amyloid and tau biomarker positivity increases with age, which is modified by APOE genotype and sex, and that there are isolated and synergistic associations with the clinical phenotype. METHODS: We included 417 patients with DLB (age 45-93 years, 31% women). Positivity on β-amyloid (A+) and tau (T+) biomarkers was determined by CSF β-amyloid1-42 and phosphorylated tau in the European cohort and by Pittsburgh compound B and AV-1451 PET in the Mayo Clinic cohort. Patients were stratified into 4 groups: A-T-, A+T-, A-T+, and A+T+. RESULTS: A-T- was the largest group (39%), followed by A+T- (32%), A+T+ (15%), and A-T+ (13%). The percentage of A-T- decreased with age, and A+ and T+ increased with age in both women and men. A+ increased more in APOE ε4 carriers with age than in noncarriers. A+ was the main predictor of lower cognitive performance when considered together with T+. T+ was associated with a lower frequency of parkinsonism and probable REM sleep behavior disorder. There were no significant interactions between A+ and T+ in relation to the clinical phenotype. CONCLUSIONS: Alzheimer disease pathologic changes are common in DLB and are associated with the clinical phenotype. β-Amyloid is associated with cognitive impairment, and tau pathology is associated with lower frequency of clinical features of DLB. These findings have important implications for diagnosis, prognosis, and disease monitoring, as well as for clinical trials targeting disease-specific proteins in DLB. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that in patients with probable DLB, β-amyloid is associated with lower cognitive performance and tau pathology is associated with lower frequency of clinical features of DLB.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
700	1	a Przybelski, Scott A.u Mayo Clinic Minnesota4 aut
700	1	a Lesnick, Timothy G.u Mayo Clinic Minnesota4 aut
700	1	a Lemstra, Afina W.u Amsterdam UMC - Vrije Universiteit Amsterdam4 aut
700	1	a Londos, Elisabetu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)pski-elo
700	1	a Blanc, Fredericu University Hospital Of Strasbourg,University of Strasbourg4 aut
700	1	a Nedelska, Zuzanau Mayo Clinic Minnesota4 aut
700	1	a Schwarz, Christopher G.u Mayo Clinic Minnesota4 aut
700	1	a Graff-Radford, Jonathanu Mayo Clinic Minnesota4 aut
700	1	a Senjem, Matthew L.u Mayo Clinic Minnesota4 aut
700	1	a Fields, Julie A.u Mayo Clinic Minnesota4 aut
700	1	a Knopman, David S.u Mayo Clinic Minnesota4 aut
700	1	a Savica, Rodolfou Mayo Clinic Minnesota4 aut
700	1	a Ferman, Tanis J.u Mayo Clinic Minnesota4 aut
700	1	a Graff-Radford, Neill R.u Mayo Clinic Minnesota4 aut
700	1	a Lowe, Val J.u Mayo Clinic Minnesota4 aut
700	1	a Jack, Clifford R.u Mayo Clinic Minnesota4 aut
700	1	a Petersen, Ronald C.u Mayo Clinic Minnesota4 aut
700	1	a Mollenhauer, Britu Paracelsus-Elena-Klinik Kassel,University of Göttingen4 aut
700	1	a Garcia-Ptacek, Sarau Karolinska Institutet,Karolinska Institute4 aut
700	1	a Abdelnour, Carlau Barcelona Alzheimer Treatment & Research Center4 aut
700	1	a Hort, Jakubu St. Anne's University Hospital Brno4 aut
700	1	a Bonanni, Laurau University G.d'Annunzio of Chieti-Pescara4 aut
700	1	a Oppedal, Ketilu Stavanger University Hospital,University of Stavanger4 aut
700	1	a Kramberger, Milica G.u University Medical Centre Ljubljana,University of Ljubljana4 aut
700	1	a Boeve, Bradley F.u Mayo Clinic Minnesota4 aut
700	1	a Aarsland, Dagu Karolinska Institutet4 aut
700	1	a Westman, Ericu Karolinska Institutet,Karolinska Institute4 aut
700	1	a Kantarci, Kejalu Mayo Clinic Minnesota4 aut
710	2	a Karolinska Instituteb Mayo Clinic Minnesota4 org
773	0	t Neurologyg 95:24, s. 3257-3268q 95:24<3257-3268x 1526-632X
856	4	u http://dx.doi.org/10.1212/WNL.0000000000010943y FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/71b0c389-e1dd-4676-bb65-3c5663b86ecd
856	4 8	u https://doi.org/10.1212/WNL.0000000000010943
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:145678535

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