Sökning: WFRF:(Shen Steve) > Large-Scale Gene-Ce...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 09916naa a2202317 4500 | |
001 | oai:lup.lub.lu.se:19739b80-cdd4-4db7-b175-028cfda89d8f | |
003 | SwePub | |
008 | 160401s2012 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/32440002 URI |
024 | 7 | a https://doi.org/10.1016/j.ajhg.2012.08.0322 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Asselbergs, Folkert W.4 aut |
245 | 1 0 | a Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci |
264 | 1 | b Elsevier BV,c 2012 |
520 | a Genome-wide association studies (GWASs) have identified many SNPs underlying variations in plasma-lipid levels. We explore whether additional loci associated with plasma-lipid phenotypes, such as high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TGs), can be identified by a dense gene-centric approach. Our meta-analysis of 32 studies in 66,240 individuals of European ancestry was based on the custom similar to 50,000 SNP genotyping array (the ITMAT-Broad-CARe array) covering similar to 2,000 candidate genes. SNP-lipid associations were replicated either in a cohort comprising an additional 24,736 samples or within the Global Lipid Genetic Consortium. We identified four, six, ten, and four unreported SNPs in established lipid genes for HDL-C, LDL-C, TC, and TGs, respectively. We also identified several lipid-related SNPs in previously unreported genes: DGAT2, HCAR2, GPIHBP1, PPARG, and FTO for HDL-C; SOCS3, APOH, SPTY2D1, BRCA2, and VLDLR for LDL-C; SOCS3, UGT1A1, BRCA2, UBE3B, FCGR2A, CHUK, and INSIG2 for TC; and SERPINF2, C4B, GCK, GATA4, INSR, and LPAL2 for TGs. The proportion of explained phenotypic variance in the subset of studies providing individual-level data was 9.9% for HDL-C, 9.5% for LDL-C, 10.3% for TC, and 8.0% for TGs. This large meta-analysis of lipid phenotypes with the use of a dense gene-centric approach identified multiple SNPs not previously described in established lipid genes and several previously unknown loci. The explained phenotypic variance from this approach was comparable to that from a meta-analysis of GWAS data, suggesting that a focused genotyping approach can further increase the understanding of heritability of plasma lipids. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Guo, Yiran4 aut |
700 | 1 | a van Iperen, Erik P. A.4 aut |
700 | 1 | a Sivapalaratnam, Suthesh4 aut |
700 | 1 | a Tragante, Vinicius4 aut |
700 | 1 | a Lanktree, Matthew B.4 aut |
700 | 1 | a Lange, Leslie A.4 aut |
700 | 1 | a Almoguera, Berta4 aut |
700 | 1 | a Appelman, Yolande E.4 aut |
700 | 1 | a Barnard, John4 aut |
700 | 1 | a Baumert, Jens4 aut |
700 | 1 | a Beitelshees, Amber L.4 aut |
700 | 1 | a Bhangale, Tushar R.4 aut |
700 | 1 | a Chen, Yii-Der Ida4 aut |
700 | 1 | a Gaunt, Tom R.4 aut |
700 | 1 | a Gong, Yan4 aut |
700 | 1 | a Hopewell, Jemma C.4 aut |
700 | 1 | a Johnson, Toby4 aut |
700 | 1 | a Kleber, Marcus E.4 aut |
700 | 1 | a Langaee, Taimour Y.4 aut |
700 | 1 | a Li, Mingyao4 aut |
700 | 1 | a Li, Yun R.4 aut |
700 | 1 | a Liu, Kiang4 aut |
700 | 1 | a McDonough, Caitrin W.4 aut |
700 | 1 | a Meijs, Matthijs El.4 aut |
700 | 1 | a Middelberg, Rita P. S.4 aut |
700 | 1 | a Musunuru, Kiran4 aut |
700 | 1 | a Nelson, Christopher P.4 aut |
700 | 1 | a O'Connell, Jeffery R.4 aut |
700 | 1 | a Padmanabhan, Sandosh4 aut |
700 | 1 | a Pankow, James S.4 aut |
700 | 1 | a Pankratz, Nathan4 aut |
700 | 1 | a Rafelt, Suzanne4 aut |
700 | 1 | a Rajagopalan, Ramakrishnan4 aut |
700 | 1 | a Romaine, Simon P. R.4 aut |
700 | 1 | a Schork, Nicholas J.4 aut |
700 | 1 | a Shaffer, Jonathan4 aut |
700 | 1 | a Shen, Haiqing4 aut |
700 | 1 | a Smith, Erin N.4 aut |
700 | 1 | a Tischfield, Sam E.4 aut |
700 | 1 | a van der Most, Peter J.4 aut |
700 | 1 | a van Vliet-Ostaptchouk, Jana V.4 aut |
700 | 1 | a Verweij, Niek4 aut |
700 | 1 | a Volcik, Kelly A.4 aut |
700 | 1 | a Zhang, Li4 aut |
700 | 1 | a Bailey, Kent R.4 aut |
700 | 1 | a Bailey, Kristian M.4 aut |
700 | 1 | a Bauer, Florianne4 aut |
700 | 1 | a Boer, Jolanda M. A.4 aut |
700 | 1 | a Braund, Peter S.4 aut |
700 | 1 | a Burt, Amber4 aut |
700 | 1 | a Burton, Paul R.4 aut |
700 | 1 | a Buxbaum, Sarah G.4 aut |
700 | 1 | a Chen, Wei4 aut |
700 | 1 | a Cooper-DeHoff, Rhonda M.4 aut |
700 | 1 | a Cupples, L. Adrienne4 aut |
700 | 1 | a deJong, Jonas S.4 aut |
700 | 1 | a Delles, Christian4 aut |
700 | 1 | a Duggan, David4 aut |
700 | 1 | a Fornage, Myriam4 aut |
700 | 1 | a Furlong, Clement E.4 aut |
700 | 1 | a Glazer, Nicole4 aut |
700 | 1 | a Gums, John G.4 aut |
700 | 1 | a Hastie, Claire4 aut |
700 | 1 | a Holmes, Michael V.4 aut |
700 | 1 | a Illig, Thomas4 aut |
700 | 1 | a Kirkland, Susan A.4 aut |
700 | 1 | a Kivimaki, Mika4 aut |
700 | 1 | a Klein, Ronald4 aut |
700 | 1 | a Klein, Barbara E.4 aut |
700 | 1 | a Kooperberg, Charles4 aut |
700 | 1 | a Kottke-Marchant, Kandice4 aut |
700 | 1 | a Kumari, Meena4 aut |
700 | 1 | a LaCroix, Andrea Z.4 aut |
700 | 1 | a Mallela, Laya4 aut |
700 | 1 | a Murugesan, Gurunathan4 aut |
700 | 1 | a Ordovas, Jose4 aut |
700 | 1 | a Ouwehand, Willem H.4 aut |
700 | 1 | a Post, Wendy S.4 aut |
700 | 1 | a Saxena, Richa4 aut |
700 | 1 | a Scharnagl, Hubert4 aut |
700 | 1 | a Schreiner, Pamela J.4 aut |
700 | 1 | a Shah, Tina4 aut |
700 | 1 | a Shields, Denis C.4 aut |
700 | 1 | a Shimbo, Daichi4 aut |
700 | 1 | a Srinivasan, Sathanur R.4 aut |
700 | 1 | a Stolk, Ronald P.4 aut |
700 | 1 | a Swerdlow, Daniel I.4 aut |
700 | 1 | a Taylor Jr, Herman A.4 aut |
700 | 1 | a Topo, Eric J.4 aut |
700 | 1 | a Toskala, Elina4 aut |
700 | 1 | a van Pelt, Joost L.4 aut |
700 | 1 | a van Setten, Jessica4 aut |
700 | 1 | a Yusuf, Salim4 aut |
700 | 1 | a Whittaker, John C.4 aut |
700 | 1 | a Zwinderman, A. H.4 aut |
700 | 1 | a Anand, Sonia S.4 aut |
700 | 1 | a Balmforth, Anthony J.4 aut |
700 | 1 | a Berenson, Gerald S.4 aut |
700 | 1 | a Bezzina, Connie R.4 aut |
700 | 1 | a Boehm, Bernhard O.4 aut |
700 | 1 | a Boerwinkle, Eric4 aut |
700 | 1 | a Casas, Juan P.4 aut |
700 | 1 | a Caulfield, Mark J.4 aut |
700 | 1 | a Clarke, Robert4 aut |
700 | 1 | a Connell, John M.4 aut |
700 | 1 | a Cruickshanks, Karen J.4 aut |
700 | 1 | a Davidson, Karina W.4 aut |
700 | 1 | a Day, Ian N. M.4 aut |
700 | 1 | a de Bakker, Paul I. W.4 aut |
700 | 1 | a Doevendans, Pieter A.4 aut |
700 | 1 | a Dominiczak, Anna E.4 aut |
700 | 1 | a Hall, Alistair S.4 aut |
700 | 1 | a Hartman, Catharina A.4 aut |
700 | 1 | a Hengstenberg, Christian4 aut |
700 | 1 | a Hillege, Hans L.4 aut |
700 | 1 | a Hofker, Marten H.4 aut |
700 | 1 | a Humphries, Steve E.4 aut |
700 | 1 | a Jarvik, Gail P.4 aut |
700 | 1 | a Johnson, Julie A.4 aut |
700 | 1 | a Kaess, Bernhard M.4 aut |
700 | 1 | a Kathiresan, Sekar4 aut |
700 | 1 | a Koenig, Wolfgang4 aut |
700 | 1 | a Lawlor, Debbie A.4 aut |
700 | 1 | a Maerz, Winfried4 aut |
700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome |
700 | 1 | a Mitchell, Braxton D.4 aut |
700 | 1 | a Montgomery, Grant W.4 aut |
700 | 1 | a Munroe, Patricia B.4 aut |
700 | 1 | a Murray, Sarah S.4 aut |
700 | 1 | a Newhouse, Stephen J.4 aut |
700 | 1 | a Onland-Moret, N. Charlotte4 aut |
700 | 1 | a Poulter, Neil4 aut |
700 | 1 | a Psaty, Bruce4 aut |
700 | 1 | a Redline, Susan4 aut |
700 | 1 | a Rich, Stephen S.4 aut |
700 | 1 | a Rotter, Jerome I.4 aut |
700 | 1 | a Schunkert, Heribert4 aut |
700 | 1 | a Sever, Peter4 aut |
700 | 1 | a Shuldiner, Alan R.4 aut |
700 | 1 | a Silverstein, Roy L.4 aut |
700 | 1 | a Stanton, Alice4 aut |
700 | 1 | a Thorand, Barbara4 aut |
700 | 1 | a Trip, Mieke D.4 aut |
700 | 1 | a Tsai, Michael Y.4 aut |
700 | 1 | a van der Harst, Pim4 aut |
700 | 1 | a van der Schoot, Ellen4 aut |
700 | 1 | a van der Schouw, Yvonne T.4 aut |
700 | 1 | a Verschuren, W. M. Monique4 aut |
700 | 1 | a Watkins, Hugh4 aut |
700 | 1 | a Wilde, Arthur A. M.4 aut |
700 | 1 | a Wolffenbuttel, Bruce H. R.4 aut |
700 | 1 | a Whitfield, John B.4 aut |
700 | 1 | a Hovingh, G. Kees4 aut |
700 | 1 | a Ballantyne, Christie M.4 aut |
700 | 1 | a Wijmenga, Cisca4 aut |
700 | 1 | a Reilly, Muredach P.4 aut |
700 | 1 | a Martin, Nicholas G.4 aut |
700 | 1 | a Wilson, James G.4 aut |
700 | 1 | a Rader, Daniel J.4 aut |
700 | 1 | a Samani, Nilesh J.4 aut |
700 | 1 | a Reiner, Alex P.4 aut |
700 | 1 | a Hegele, Robert A.4 aut |
700 | 1 | a Kastelein, John J. P.4 aut |
700 | 1 | a Hingorani, Aroon D.4 aut |
700 | 1 | a Talmud, Philippa J.4 aut |
700 | 1 | a Hakonarson, Hakon4 aut |
700 | 1 | a Elbers, Clara C.4 aut |
700 | 1 | a Keating, Brendan J.4 aut |
700 | 1 | a Drenos, Fotios4 aut |
710 | 2 | a Kardiovaskulär forskning - hypertonib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t American Journal of Human Geneticsd : Elsevier BVg 91:5, s. 823-838q 91:5<823-838x 0002-9297 |
856 | 4 | u http://dx.doi.org/10.1016/j.ajhg.2012.08.032y FULLTEXT |
856 | 4 | u https://doi.org/10.1016/j.ajhg.2012.08.032 |
856 | 4 8 | u https://lup.lub.lu.se/record/3244000 |
856 | 4 8 | u https://doi.org/10.1016/j.ajhg.2012.08.032 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy