WFRF:(Viljanen T)
Sökning: WFRF:(Viljanen T) > Short telomere leng...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05449naa a2200877 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:135958451 | |
| 003 | SwePub | |
| 008 | 240701s2017 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:umu-136343 | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1359584512 URI |
| 024 | 7 | a https://doi.org/10.1038/tp.2017.732 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1363432 URI |
| 040 | a (SwePub)kid (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Hagg, Su Karolinska Institutet4 aut |
| 245 | 1 0 | a Short telomere length is associated with impaired cognitive performance in European ancestry cohorts |
| 264 | c 2017-04-18 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2017 |
| 520 | a The association between telomere length (TL) dynamics on cognitive performance over the life-course is not well understood. This study meta-analyses observational and causal associations between TL and six cognitive traits, with stratifications on APOE genotype, in a Mendelian Randomization (MR) framework. Twelve European cohorts (N=17 052; mean age=59.2±8.8 years) provided results for associations between qPCR-measured TL (T/S-ratio scale) and general cognitive function, mini-mental state exam (MMSE), processing speed by digit symbol substitution test (DSST), visuospatial functioning, memory and executive functioning (STROOP). In addition, a genetic risk score (GRS) for TL including seven known genetic variants for TL was calculated, and used in associations with cognitive traits as outcomes in all cohorts. Observational analyses showed that longer telomeres were associated with better scores on DSST (β=0.051 per s.d.-increase of TL; 95% confidence interval (CI): 0.024, 0.077; P=0.0002), and MMSE (β=0.025; 95% CI: 0.002, 0.047; P=0.03), and faster STROOP (β=−0.053; 95% CI: −0.087, −0.018; P=0.003). Effects for DSST were stronger in APOE ɛ4 non-carriers (β=0.081; 95% CI: 0.045, 0.117; P=1.0 × 10−5), whereas carriers performed better in STROOP (β=−0.074; 95% CI: −0.140, −0.009; P=0.03). Causal associations were found for STROOP only (β=−0.598 per s.d.-increase of TL; 95% CI: −1.125, −0.072; P=0.026), with a larger effect in ɛ4-carriers (β=−0.699; 95% CI: −1.330, −0.069; P=0.03). Two-sample replication analyses using CHARGE summary statistics showed causal effects between TL and general cognitive function and DSST, but not with STROOP. In conclusion, we suggest causal effects from longer TL on better cognitive performance, where APOE ɛ4-carriers might be at differential risk. | |
| 650 | 7 | a SAMHÄLLSVETENSKAPx Psykologix Psykologi0 (SwePub)501012 hsv//swe |
| 650 | 7 | a SOCIAL SCIENCESx Psychologyx Psychology0 (SwePub)501012 hsv//eng |
| 700 | 1 | a Zhan, Yu Karolinska Institutet4 aut |
| 700 | 1 | a Karlsson, Ru Karolinska Institutet4 aut |
| 700 | 1 | a Gerritsen, L4 aut |
| 700 | 1 | a Ploner, Au Karolinska Institutet4 aut |
| 700 | 1 | a van der Lee, SJ4 aut |
| 700 | 1 | a Broer, L4 aut |
| 700 | 1 | a Deelen, J4 aut |
| 700 | 1 | a Marioni, RE4 aut |
| 700 | 1 | a Wong, A4 aut |
| 700 | 1 | a Lundquist, Andersu Umeå universitet,Statistik4 aut0 (Swepub:umu)anslst97 |
| 700 | 1 | a Zhu, G4 aut |
| 700 | 1 | a Hansell, NK4 aut |
| 700 | 1 | a Sillanpaa, E4 aut |
| 700 | 1 | a Fedko, IO4 aut |
| 700 | 1 | a Amin, NA4 aut |
| 700 | 1 | a Beekman, M4 aut |
| 700 | 1 | a de Craen, AJM4 aut |
| 700 | 1 | a Degerman, Sofieu Umeå universitet,Patologi4 aut0 (Swepub:umu)soiden99 |
| 700 | 1 | a Harris, SE4 aut |
| 700 | 1 | a Kan, KJ4 aut |
| 700 | 1 | a Martin-Ruiz, CM4 aut |
| 700 | 1 | a Montgomery, GW4 aut |
| 700 | 1 | a Adolfsson, Annelie N.u Umeå universitet,Psykiatri4 aut0 (Swepub:umu)anenon01 |
| 700 | 1 | a Reynolds, CA4 aut |
| 700 | 1 | a Samani, NJ4 aut |
| 700 | 1 | a Suchiman, HED4 aut |
| 700 | 1 | a Viljanen, A4 aut |
| 700 | 1 | a von Zglinicki, T4 aut |
| 700 | 1 | a Wright, MJ4 aut |
| 700 | 1 | a Hottenga, JJ4 aut |
| 700 | 1 | a Boomsma, DI4 aut |
| 700 | 1 | a Rantanen, T4 aut |
| 700 | 1 | a Kaprio, JA4 aut |
| 700 | 1 | a Nyholt, DR4 aut |
| 700 | 1 | a Martin, NG4 aut |
| 700 | 1 | a Nyberg, Larsu Karolinska Institutet,Umeå universitet,Institutionen för strålningsvetenskaper,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)4 aut0 (Swepub:umu)lany0001 |
| 700 | 1 | a Adolfsson, Rolfu Umeå universitet,Psykiatri4 aut0 (Swepub:umu)road0001 |
| 700 | 1 | a Kuh, D4 aut |
| 700 | 1 | a Starr, JM4 aut |
| 700 | 1 | a Deary, IJ4 aut |
| 700 | 1 | a Slagboom, PE4 aut |
| 700 | 1 | a van Duijn, CM4 aut |
| 700 | 1 | a Codd, V4 aut |
| 700 | 1 | a Pedersen, NLu Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutetb Statistik4 org |
| 773 | 0 | t Translational psychiatryd : Springer Science and Business Media LLCg 7:4, s. e1100-q 7:4<e1100-x 2158-3188 |
| 856 | 4 | u https://www.nature.com/articles/tp201773.pdf |
| 856 | 4 | u https://doi.org/10.1038/tp.2017.73y Fulltext |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1110627/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:135958451 |
| 856 | 4 8 | u https://doi.org/10.1038/tp.2017.73 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-136343 |
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