High birth weight was not associated with altered body composition or impaired glucose tolerance in adulthood

• Aim To investigate whether a high birth weight was associated with an increased proportion of body fat or with impaired glucose tolerance in adulthood.Methods Our cohort comprised 27 subjects with birth weights of 4,500 g or more, and 27 controls with birth weights within ±1 SDS, born at Uppsala University Hospital 1975-1979. The subjects were 34-40 years old at the time of study.Anthropometric data was collected, and data on body composition was obtained by air plethysmography and bioimpedance and was estimated with a three compartment model. Indirect calorimetry, blood sampling for fasting insulin and glucose as well as a 75 g oral glucose tolerance test were also performed. Insulin sensitivity was assessed using homeostasis model assessment 2 (HOMA2) and Matsuda index. Areas under the curves were calculated for insulin and glucose.Results There were no differences in body mass index, body composition or insulin sensitivity between subjects with a high birth weight and controls.Conclusion Adult subjects, born with a moderately high birth weight, did not differ from those with birth weights within ±1 SDS regarding body composition or glucose tolerance

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Pediatrik (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Pediatrics (hsv//eng)

Nyckelord

Body composition

Glucose tolerance

High birth weight

Insulin sensitivity

Obesity

Endocrinology and Diabetology

Endokrinologi och Diabetologi

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)