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Pharmacological treatment of migraine : Drug classes, mechanisms of action, clinical trials and new treatments
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- Zobdeh, Farzin (author)
- Uppsala universitet,Schiöth: Funktionell farmakologi,Department of Pharmacology, Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
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- Ben Kraiem, Aziza (author)
- Uppsala universitet,Schiöth: Funktionell farmakologi,1Department of Pharmacology, Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
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- Attwood, Misty M. (author)
- Uppsala universitet,Schiöth: Funktionell farmakologi
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- Chubarev, Vladimir N (author)
- Tarasov, Vadim V (author)
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- (creator_code:org_t)
- 2021-09-26
- 2021
- English.
- In: British Journal of Pharmacology. - : John Wiley & Sons. - 0007-1188 .- 1476-5381. ; 178:23, s. 4588-4607
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Migraine is the sixth most prevalent disease globally, a major cause of disability, and it imposes an enormous personal and socio-economic burden. Migraine treatment is often limited by insufficient therapy response, leading to the need for individually adjusted treatment. In this review, we analyse historical and current pharmaceutical development approaches in acute and chronic migraine based on a comprehensive and systematic analysis of Food and Drug Administration (FDA)-approved drugs and those under investigation. The development of migraine therapeutics has significantly intensified during the last 3 years, as shown by our analysis of the trends of drug development between 1970 and 2020. The spectrum of drug targets has expanded considerably, which has been accompanied by an increase in the number of specialised clinical trials. This review highlights the mechanistic implications of FDA-approved and currently investigated drugs and discusses current and future therapeutic options based on identified drug classes of interest.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- 5-HT
- CGRP
- clinical trials
- migraine
- migraine acute treatment
- migraine chronic treatment
Publication and Content Type
- ref (subject category)
- art (subject category)
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