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  • Dossus, LaureDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)

Tumor necrosis factor (TNF)-α, soluble TNF receptors and endometrial cancer risk : the EPIC study

  • Artikel/kapitelEngelska2011

Förlag, utgivningsår, omfång ...

  • 2011-03-08
  • Geneve :International union against cancer,2011
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-41629
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-41629URI
  • https://doi.org/10.1002/ijc.25840DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Chronic inflammation has been hypothesized to play a role in endometrial cancer development. Tumor necrosis factor-α (TNF-α), one of the major pro-inflammatory cytokines, has also been implicated in endometrial physiology. We conducted a case-control study nested within the European prospective investigation into cancer and nutrition (EPIC) to examine the association of TNF-α and its two soluble receptors (sTNFR1 and sTNFR2) with endometrial cancer risk. Two-hundred-seventy cases and 518 matched controls were analyzed using conditional logistic regression. All statistical tests were two-sided. We observed an increased risk of endometrial cancer among women in the highest versus lowest quartile of TNF-α (odds ratio [OR]: 1.73, 95% CI: 1.09-2.73, Ptrend = 0.01), sTNFR1 (OR: 1.68, 95% CI: 0.99-2.86, Ptrend = 0.07) and sTNFR2 (OR: 1.53, 95%CI: 0.92-2.55, Ptrend = 0.03) after adjustment for body-mass-index, parity, age at menopause and previous postmenopausal hormone therapy use. Further adjustments for estrogens and C-peptide had minor effect on risk estimates. Our data show that elevated prediagnostic concentrations of TNF-α and its soluble receptors are related to a higher risk of endometrial cancer, particularly strong in women diagnosed within 2 years of blood donation. This is the first study of its kind and therefore deserves replication in further prospective studies.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Becker, SusenDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
  • Rinaldi, SabinaSection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France (författare)
  • Lukanova, AnnekatrinDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
  • Tjønneland, AnneInstitute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark (författare)
  • Olsen, AnjaInstitute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark (författare)
  • Overvad, KimDepartment of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark (författare)
  • Chabbert-Buffet, NathalieDepartment of Obstetrics and Gynecology, APHP Hospital Tenon and UMPC, Paris, France (författare)
  • Boutron-Ruault, Marie-ChristineINSERM, Centre for Research in Epidemiology and Population Health, Paris South University, Gustave Roussy Institute, Villejuif, France (författare)
  • Clavel-Chapelon, FrançoiseINSERM, Centre for Research in Epidemiology and Population Health, Paris South University, Gustave Roussy Institute, Villejuif, France (författare)
  • Teucher, BirgitDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
  • Chang-Claude, JennyDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
  • Pischon, TobiasDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany (författare)
  • Boeing, HeinerDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany (författare)
  • Trichopoulou, AntoniaDepartment of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, Athens, Greece (författare)
  • Benetou, VasilikiDepartment of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, Athens, Greece (författare)
  • Valanou, ElisavetDepartment of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, Athens, Greece (författare)
  • Palli, DomenicoMolecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy (författare)
  • Sieri, SabinaDepartment of Preventive and Predictive Medicine, Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy (författare)
  • Tumino, RosarioCancer Registry and Histopathology Unit, “Civile – M.P. Arezzo” Hospital, Ragusa, Italy (författare)
  • Sacerdote, CarlottaCenter for Cancer Prevention (CPO Piedmont), Turin, Italy (författare)
  • Galasso, RoccoInstituto di Ricovero e Cura a Carattere Scientifico (IRCCS-CROOB), Rionero in Vulture (PZ), Italy (författare)
  • Redondo, Maria-LuísaPublic Health and Participation Directorate, Health and Health Care Services Council, Asturias, Spain (författare)
  • Bonet Bonet, CatalinaUnit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Barcelona, Spain (författare)
  • Molina-Montes, EstherAndalusian School of Public Health, Granada, Spain (författare)
  • Altzibar, Jone MCIBER de Epidemiología y Salud Pública (CIBERESP), Spain (författare)
  • Chirlaque, Maria-DoloresCIBER de Epidemiología y Salud Pública (CIBERESP), Spain (författare)
  • Ardanaz, EvaCIBER de Epidemiología y Salud Pública (CIBERESP), Spain (författare)
  • Bueno-de-Mesquita, H BasCIBER de Epidemiología y Salud Pública (CIBERESP), Spain (författare)
  • van Duijnhoven, Fränzel J BNational Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands (författare)
  • Peeters, Petra H MJulius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands (författare)
  • Onland-Moret, N CharlotteJulius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands (författare)
  • Lundin, EvaUmeå universitet,Patologi(Swepub:umu)evlu0001 (författare)
  • Idahl, AnnikaUmeå universitet,Obstetrik och gynekologi,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)anid0002 (författare)
  • Khaw, Kay-TeeDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom (författare)
  • Wareham, NicholasMRC Epidemiology Unit, Cambridge, United Kingdom (författare)
  • Allen, NaomiNuffield Department of Clinical Medicine, Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom (författare)
  • Romieu, IsabelleInternational Agency for Research on Cancer, Lyon, France (författare)
  • Fedirko, VeronikaInternational Agency for Research on Cancer, Lyon, France (författare)
  • Hainaut, PierreDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom (författare)
  • Romaguera, DoraDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom (författare)
  • Norat, TeresaDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom (författare)
  • Riboli, ElioDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom (författare)
  • Kaaks, RudolfDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
  • Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, GermanySection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:International Journal of CancerGeneve : International union against cancer129:8, s. 2032-20370020-71361097-0215

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