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Sökning: WFRF:(Bueno de Mesquita H. B. Bas) > Tumor necrosis fact...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00009182naa a2200925 4500
001oai:DiVA.org:umu-41629
003SwePub
008110330s2011 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-416292 URI
0247 a https://doi.org/10.1002/ijc.258402 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Dossus, Laureu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut
2451 0a Tumor necrosis factor (TNF)-α, soluble TNF receptors and endometrial cancer risk :b the EPIC study
264 c 2011-03-08
264 1a Geneve :b International union against cancer,c 2011
338 a print2 rdacarrier
520 a Chronic inflammation has been hypothesized to play a role in endometrial cancer development. Tumor necrosis factor-α (TNF-α), one of the major pro-inflammatory cytokines, has also been implicated in endometrial physiology. We conducted a case-control study nested within the European prospective investigation into cancer and nutrition (EPIC) to examine the association of TNF-α and its two soluble receptors (sTNFR1 and sTNFR2) with endometrial cancer risk. Two-hundred-seventy cases and 518 matched controls were analyzed using conditional logistic regression. All statistical tests were two-sided. We observed an increased risk of endometrial cancer among women in the highest versus lowest quartile of TNF-α (odds ratio [OR]: 1.73, 95% CI: 1.09-2.73, Ptrend = 0.01), sTNFR1 (OR: 1.68, 95% CI: 0.99-2.86, Ptrend = 0.07) and sTNFR2 (OR: 1.53, 95%CI: 0.92-2.55, Ptrend = 0.03) after adjustment for body-mass-index, parity, age at menopause and previous postmenopausal hormone therapy use. Further adjustments for estrogens and C-peptide had minor effect on risk estimates. Our data show that elevated prediagnostic concentrations of TNF-α and its soluble receptors are related to a higher risk of endometrial cancer, particularly strong in women diagnosed within 2 years of blood donation. This is the first study of its kind and therefore deserves replication in further prospective studies.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a tumor necrosis factor (TNF)-α
653 a soluble TNF receptors
653 a inflammation
653 a endometrial cancer
653 a prospective
653 a MEDICINE
653 a MEDICIN
653 a Pathology
653 a patologi
7001 a Becker, Susenu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut
7001 a Rinaldi, Sabinau Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France4 aut
7001 a Lukanova, Annekatrinu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut
7001 a Tjønneland, Anneu Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark4 aut
7001 a Olsen, Anjau Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark4 aut
7001 a Overvad, Kimu Department of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark4 aut
7001 a Chabbert-Buffet, Nathalieu Department of Obstetrics and Gynecology, APHP Hospital Tenon and UMPC, Paris, France4 aut
7001 a Boutron-Ruault, Marie-Christineu INSERM, Centre for Research in Epidemiology and Population Health, Paris South University, Gustave Roussy Institute, Villejuif, France4 aut
7001 a Clavel-Chapelon, Françoiseu INSERM, Centre for Research in Epidemiology and Population Health, Paris South University, Gustave Roussy Institute, Villejuif, France4 aut
7001 a Teucher, Birgitu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut
7001 a Chang-Claude, Jennyu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut
7001 a Pischon, Tobiasu Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany4 aut
7001 a Boeing, Heineru Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany4 aut
7001 a Trichopoulou, Antoniau Department of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, Athens, Greece4 aut
7001 a Benetou, Vasilikiu Department of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, Athens, Greece4 aut
7001 a Valanou, Elisavetu Department of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, Athens, Greece4 aut
7001 a Palli, Domenicou Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy4 aut
7001 a Sieri, Sabinau Department of Preventive and Predictive Medicine, Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy4 aut
7001 a Tumino, Rosariou Cancer Registry and Histopathology Unit, “Civile – M.P. Arezzo” Hospital, Ragusa, Italy4 aut
7001 a Sacerdote, Carlottau Center for Cancer Prevention (CPO Piedmont), Turin, Italy4 aut
7001 a Galasso, Roccou Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS-CROOB), Rionero in Vulture (PZ), Italy4 aut
7001 a Redondo, Maria-Luísau Public Health and Participation Directorate, Health and Health Care Services Council, Asturias, Spain4 aut
7001 a Bonet Bonet, Catalinau Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Barcelona, Spain4 aut
7001 a Molina-Montes, Estheru Andalusian School of Public Health, Granada, Spain4 aut
7001 a Altzibar, Jone Mu CIBER de Epidemiología y Salud Pública (CIBERESP), Spain4 aut
7001 a Chirlaque, Maria-Doloresu CIBER de Epidemiología y Salud Pública (CIBERESP), Spain4 aut
7001 a Ardanaz, Evau CIBER de Epidemiología y Salud Pública (CIBERESP), Spain4 aut
7001 a Bueno-de-Mesquita, H Basu CIBER de Epidemiología y Salud Pública (CIBERESP), Spain4 aut
7001 a van Duijnhoven, Fränzel J Bu National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands4 aut
7001 a Peeters, Petra H Mu Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands4 aut
7001 a Onland-Moret, N Charlotteu Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands4 aut
7001 a Lundin, Evau Umeå universitet,Patologi4 aut0 (Swepub:umu)evlu0001
7001 a Idahl, Annikau Umeå universitet,Obstetrik och gynekologi,Institutionen för folkhälsa och klinisk medicin4 aut0 (Swepub:umu)anid0002
7001 a Khaw, Kay-Teeu Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom4 aut
7001 a Wareham, Nicholasu MRC Epidemiology Unit, Cambridge, United Kingdom4 aut
7001 a Allen, Naomiu Nuffield Department of Clinical Medicine, Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom4 aut
7001 a Romieu, Isabelleu International Agency for Research on Cancer, Lyon, France4 aut
7001 a Fedirko, Veronikau International Agency for Research on Cancer, Lyon, France4 aut
7001 a Hainaut, Pierreu Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom4 aut
7001 a Romaguera, Dorau Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom4 aut
7001 a Norat, Teresau Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom4 aut
7001 a Riboli, Eliou Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom4 aut
7001 a Kaaks, Rudolfu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut
7102 a Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germanyb Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France4 org
7730 t International Journal of Cancerd Geneve : International union against cancerg 129:8, s. 2032-2037q 129:8<2032-2037x 0020-7136x 1097-0215
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.25840
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-41629
8564 8u https://doi.org/10.1002/ijc.25840

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