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Sökning: WFRF:(Carlsson R.) > (2010-2014) > The hanta hunting s...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003572naa a2200409 4500
001oai:DiVA.org:uu-233591
003SwePub
008141007s2014 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2335912 URI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Goeijenbier, M.4 aut
2451 0a The hanta hunting study :b underdiagnosis of Puumala hantavirus infections in symptomatic non-travelling leptospirosis-suspected patients in the Netherlands, in 2010 and April to November 2011
264 1c 2014
338 a print2 rdacarrier
520 a Leptospirosis and haemorrhagic fever with renal syndrome (HFRS) are hard to distinguish clinically since these two important rodent-borne zoonoses share hallmark symptoms such as renal failure and haemorrhage. Leptospirosis is caused by infection with a spirochete while HFRS is the result of an infection with certain hantaviruses. Both diseases are relatively rare in the Netherlands. Increased incidence of HFRS has been observed since 2007 in countries that border the Netherlands. Since a similar rise in incidence has not been registered in the Netherlands, we hypothesise that due to overlapping clinical manifestations, hantavirus infections may be confused with leptospirosis, leading to underdiagnosis. Therefore, we tested a cohort of non-travelling Dutch patients with symptoms compatible with leptospirosis, but with a negative diagnosis, during 2010 and from April to November 2011. Sera were screened with pan-hantavirus IgG and IgM enzyme-linked immunosorbent assays (ELISAs). Sera with IgM reactivity were tested by immunofluorescence assay (IFA). ELISA (IgM positive) and IFA results were confirmed using focus reduction neutralisation tests (FRNTs). We found hantavirus-specific IgG and/or IgM antibodies in 4.3% (11/255) of samples taken in 2010 and in 4.1% (6/146) of the samples during the 2011 period. After FRNT confirmation, seven patients were classed as having acute Puumala virus infections. A review of hantavirus diagnostic requests revealed that at least three of the seven confirmed acute cases as well as seven probable acute cases of hantavirus infection were missed in the Netherlands during the study period.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
7001 a Hartskeerl, R. A.4 aut
7001 a Reimerink, J.4 aut
7001 a Verner-Carlsson, J.4 aut
7001 a Wagenaar, J. F.4 aut
7001 a Goris, M. G.4 aut
7001 a Martina, B. E.4 aut
7001 a Lundkvist, Åkeu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi4 aut0 (Swepub:uu)akelu185
7001 a Koopmans, M.4 aut
7001 a Osterhaus, A. D.4 aut
7001 a van Gorp, E. C.4 aut
7001 a Reusken, C. B.4 aut
7102 a Uppsala universitetb Institutionen för medicinsk biokemi och mikrobiologi4 org
7730 t Eurosurveillanceg 19:32, s. 27-36q 19:32<27-36x 1025-496Xx 1560-7917
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-233591

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