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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 14620naa a2201489 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:135101399 | |
| 003 | SwePub | |
| 008 | 240701s2017 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:uu-316933 | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1351013992 URI |
| 024 | 7 | a https://doi.org/10.1038/ncomms141752 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3169332 URI |
| 040 | a (SwePub)kid (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Law, PJu Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.4 aut |
| 245 | 1 0 | a Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia |
| 264 | c 2017-02-06 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2017 |
| 520 | a Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10−13), 1q42.13 (rs41271473, P=1.06 × 10−10), 4q24 (rs71597109, P=1.37 × 10−10), 4q35.1 (rs57214277, P=3.69 × 10−8), 6p21.31 (rs3800461, P=1.97 × 10−8), 11q23.2 (rs61904987, P=2.64 × 10−11), 18q21.1 (rs1036935, P=3.27 × 10−8), 19p13.3 (rs7254272, P=4.67 × 10−8) and 22q13.33 (rs140522, P=2.70 × 10−9). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 700 | 1 | a Berndt, SIu NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.4 aut |
| 700 | 1 | a Speedy, HEu Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.,Statens Serum Inst, Div Hlth Surveillance & Res, Dept Epidemiol Res, DK-2300 Copenhagen, Denmark.4 aut |
| 700 | 1 | a Camp, NJu Univ Utah, Sch Med, Dept Internal Med, Huntsman Canc Inst, Salt Lake City, UT 84112 USA.4 aut |
| 700 | 1 | a Sava, GPu Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.,Birmingham Heartlands Hosp, Dept Haematol, Birmingham B9 5SS, W Midlands, England.4 aut |
| 700 | 1 | a Skibola, CFu Univ Alabama Birmingham, Dept Epidemiol, Sch Publ Hlth, Birmingham, AL 35233 USA.;Univ Alabama Birmingham, Ctr Comprehens Canc, Birmingham, AL 35233 USA.,Cardiff & Vale Natl Hlth Serv Trust, Heath Pk, Cardiff CF14 4XW, S Glam, Wales.4 aut |
| 700 | 1 | a Holroyd, Au Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.4 aut |
| 700 | 1 | a Joseph, Vu Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA.4 aut |
| 700 | 1 | a Sunter, NJu Newcastle Univ, Northern Inst Canc Res, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.4 aut |
| 700 | 1 | a Nieters, Au Univ Med Ctr Freiburg, Ctr Chron Immunodeficiency, D-79108 Freiburg, Baden Wurttembe, Germany.4 aut |
| 700 | 1 | a Bea, Su Hosp Clin Barcelona, Inst Invest Biomed August Pi ISunyer IDIBAPS, Barcelona 08036, Spain.4 aut |
| 700 | 1 | a Monnereau, Au Inserm U1219 EPICENE, Inst Bergonie, Registre Hemopathies Malignes Gironde, F-33076 Bordeaux, France.;Ctr Res Epidemiol & Stat Sorbonne Paris Cite CRES, INSERM, Epidemiol Childhood & Adolescent Canc Grp, F-94807 Paris, France.;Univ Paris 05, F-75270 Paris, France.,Newcastle Univ, Northern Inst Canc Res, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.4 aut |
| 700 | 1 | a Martin-Garcia, Du Hosp Clin Barcelona, Inst Invest Biomed August Pi ISunyer IDIBAPS, Barcelona 08036, Spain.4 aut |
| 700 | 1 | a Rosenquist, Richardu Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab,Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA.4 aut0 (Swepub:uu)richrose |
| 700 | 1 | a Clot, Gu Hosp Clin Barcelona, Inst Invest Biomed August Pi ISunyer IDIBAPS, Barcelona 08036, Spain.4 aut |
| 700 | 1 | a Teras, LRu Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30303 USA.4 aut |
| 700 | 1 | a Quintela, Iu Univ Santiago de Compostela, Grp Med Xenom, Ctr Nacl Genotipado CeGen ISCIII PRB2, CIBERER, Santiago De Compostela 15782, Spain.4 aut |
| 700 | 1 | a Birmann, BMu Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.,Statens Serum Inst, Div Hlth Surveillance & Res, Dept Epidemiol Res, DK-2300 Copenhagen, Denmark.;Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA.,Univ Burgundy, Registre Hemopathies Malignes Cote dOr, F-21070 Dijon, France.;Dijon Univ Hosp, F-21070 Dijon, France.4 aut |
| 700 | 1 | a Jayne, Su Univ Leicester, Ernest & Helen Scott Haematol Res Inst, Leicester LE2 7LX, Leics, England.,BC Canc Agcy, Canc Control Res, Vancouver, BC V5Z 1L3, Canada.;Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC V6T 1Z3, Canada.,NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.4 aut |
| 700 | 1 | a Cozen, Wu Univ Southern Calif, USC Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.;Univ Southern Calif, USC Keck Sch Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA.4 aut |
| 700 | 1 | a Majid, Au Univ Leicester, Ernest & Helen Scott Haematol Res Inst, Leicester LE2 7LX, Leics, England.,Hull & East Yorkshire NHS Trust, Castle Hill Hosp, Queens Ctr Haematol & Oncol, Cottingham HU16 5JQ, England.4 aut |
| 700 | 1 | a Smedby, KEu Karolinska Institutet,Karolinska Inst, Clin Epidemiol Unit, Dept Med Solna, Hematol Ctr,Karolinsak Univ Hosp, S-17176 Stockholm, Sweden.4 aut |
| 700 | 1 | a Lan, Qu NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.4 aut |
| 700 | 1 | a Dearden, Cu Royal Marsden NHS Fdn Trust, Sutton SM2 5PT, Surrey, England.4 aut |
| 700 | 1 | a Brooks-Wilson, ARu BC Canc Agcy, Genome Sci Ctr, Vancouver, BC V5Z 1L3, Canada.;Simon Fraser Univ, Dept Biomed Physiol & Kinesiol, Burnaby, BC V5A 1S6, Canada.4 aut |
| 700 | 1 | a Hall, AGu Newcastle Univ, Northern Inst Canc Res, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.4 aut |
| 700 | 1 | a Purdue, MPu NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.4 aut |
| 700 | 1 | a Mainou-Fowler, Tu Newcastle Univ, Sch Med, Haematol Sci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.4 aut |
| 700 | 1 | a Vajdic, CMu Univ New South Wales, Ctr Big Data Res Hlth, Sydney, NSW 2052, Australia.4 aut |
| 700 | 1 | a Jackson, GHu Royal Victoria Infirm, Dept Haematol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England.4 aut |
| 700 | 1 | a Cocco, Pu Univ Cagliari Monserrato, Dept Publ Hlth Clin & Mol Med, I-09042 Cagliari, Italy.4 aut |
| 700 | 1 | a Marr, Hu Newcastle Univ, Northern Inst Canc Res, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.4 aut |
| 700 | 1 | a Zhang, YWu Yale Sch Publ Hlth, Dept Environm Hlth Sci, New Haven, CT 06520 USA.4 aut |
| 700 | 1 | a Zheng, TZu Yale Sch Publ Hlth, Dept Environm Hlth Sci, New Haven, CT 06520 USA.4 aut |
| 700 | 1 | a Giles, GGu Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic 3004, Australia.;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic 3010, Australia.,Mayo Clin, Div Hematol, Rochester, MN 55905 USA.4 aut |
| 700 | 1 | a Lawrence, Cu Westat Corp, Rockville, MD 20850 USA.4 aut |
| 700 | 1 | a Call, TG4 aut |
| 700 | 1 | a Liebow, Mu Mayo Clin, Dept Med, Rochester, MN 55905 USA.,Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic 3004, Australia.;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic 3010, Australia.4 aut |
| 700 | 1 | a Melbye, Mu Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94118 USA.,NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.,Univ Bari, Interdisciplinary Dept Med, I-70124 Bari, Italy.4 aut |
| 700 | 1 | a Glimelius, Bengtu Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)bengglim |
| 700 | 1 | a Mansouri, Larryu Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)maman377 |
| 700 | 1 | a Glenn, Mu Univ Utah, Sch Med, Dept Internal Med, Huntsman Canc Inst, Salt Lake City, UT 84112 USA.4 aut |
| 700 | 1 | a Curtin, Ku Univ Utah, Sch Med, Dept Internal Med, Huntsman Canc Inst, Salt Lake City, UT 84112 USA.4 aut |
| 700 | 1 | a Diver, WRu Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30303 USA.4 aut |
| 700 | 1 | a Link, BKu Univ Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA.4 aut |
| 700 | 1 | a Conde, Lu Univ Alabama Birmingham, Dept Epidemiol, Sch Publ Hlth, Birmingham, AL 35233 USA.;Univ Alabama Birmingham, Ctr Comprehens Canc, Birmingham, AL 35233 USA.4 aut |
| 700 | 1 | a Bracci, PM4 aut |
| 700 | 1 | a Holly, EAu Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94118 USA.4 aut |
| 700 | 1 | a Jackson, RDu Ohio State Univ, Div Endocrinol Diabet & Metab, Columbus, OH 43210 USA.4 aut |
| 700 | 1 | a Tinker, LFu Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98117 USA.4 aut |
| 700 | 1 | a Benavente, Yu Catalan Inst Oncol IDIBELL, Canc Epidemiol Res Programme, Barcelona 08908, Spain.;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona 08036, Spain.4 aut |
| 700 | 1 | a Boffetta, Pu Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA.4 aut |
| 700 | 1 | a Brennan, Pu Int Agcy Res Canc, F-69372 Lyon, France.4 aut |
| 700 | 1 | a Maynadie, M4 aut |
| 700 | 1 | a McKay, Ju Int Agcy Res Canc, F-69372 Lyon, France.4 aut |
| 700 | 1 | a Albanes, Du NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.4 aut |
| 700 | 1 | a Weinstein, Su NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.4 aut |
| 700 | 1 | a Wang, ZMu St Jude Childrens Res Hosp, Dept Computat Biol, 332 N Lauderdale St, Memphis, TN 38105 USA.4 aut |
| 700 | 1 | a Caporaso, NEu NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.4 aut |
| 700 | 1 | a Morton, LMu Canc Prevent & Res Inst ISPO, Environm & Occupat Epidemiol Unit, I-50139 Florence, Italy.4 aut |
| 700 | 1 | a Severson, RKu Wayne State Univ, Dept Family Med & Publ Hlth Sci, Detroit, MI 48201 USA.4 aut |
| 700 | 1 | a Riboli, Eu Imperial Coll London, Sch Publ Hlth, London W2 1PG, England.4 aut |
| 700 | 1 | a Vineis, Pu Imperial Coll London, Sch Publ Hlth, MRC PHE Ctr Environm & Hlth, London W2 1PG, England.;Human Genet Fdn, I-10126 Turin, Italy.4 aut |
| 700 | 1 | a Vermeulen, RCHu Univ Utrecht, Inst Risk Assessment Sci, NL-3508 TD Utrecht, Netherlands.;Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, NL-3584 CX Utrecht, Netherlands.,Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.4 aut |
| 700 | 1 | a Southey, MCu Univ Melbourne, Dept Pathol, Genet Epidemiol Lab, Melbourne, Vic 3010, Australia.4 aut |
| 700 | 1 | a Milne, RL4 aut |
| 700 | 1 | a Clavel, Ju Ctr Res Epidemiol & Stat Sorbonne Paris Cite CRES, INSERM, Epidemiol Childhood & Adolescent Canc Grp, F-94807 Paris, France.;Univ Paris 05, F-75270 Paris, France.4 aut |
| 700 | 1 | a Topka, Su Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA.4 aut |
| 700 | 1 | a Spinelli, JJ4 aut |
| 700 | 1 | a Kraft, Pu Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.4 aut |
| 700 | 1 | a Ennas, MGu Univ Cagliari, Dept Biomed Sci, I-09042 Cagliari, Italy.4 aut |
| 700 | 1 | a Summerfield, Gu Queen Elizabeth Hosp, Dept Haematol, Gateshead NE9 6SX, England.4 aut |
| 700 | 1 | a Ferri, GM4 aut |
| 700 | 1 | a Harris, RJu Univ Liverpool, Dept Mol & Clin Canc Med, Liverpool L69 3BX, Merseyside, England.4 aut |
| 700 | 1 | a Miligi, L4 aut |
| 700 | 1 | a Pettitt, ARu Univ Liverpool, Dept Mol & Clin Canc Med, Liverpool L69 3BX, Merseyside, England.4 aut |
| 700 | 1 | a North, KEu Univ North Carolina Chapel Hill, Dept Epidemiol, Chapel Hill, NC 27599 USA.;Univ North Carolina Chapel Hill, Carolina Ctr Genome Sci, Chapel Hill, NC 27599 USA.4 aut |
| 700 | 1 | a Allsup, DJ4 aut |
| 700 | 1 | a Fraumeni, JFu NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.4 aut |
| 700 | 1 | a Bailey, JRu Hull & East Yorkshire NHS Trust, Castle Hill Hosp, Queens Ctr Haematol & Oncol, Cottingham HU16 5JQ, England.4 aut |
| 700 | 1 | a Offit, Ku Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA.4 aut |
| 700 | 1 | a Pratt, G4 aut |
| 700 | 1 | a Hjalgrim, H4 aut |
| 700 | 1 | a Pepper, Cu Cardiff Univ, Sch Med, Div Canc & Genet, Cardiff CF14 4XN, S Glam, Wales.4 aut |
| 700 | 1 | a Chanock, SJ4 aut |
| 700 | 1 | a Fegan, C4 aut |
| 700 | 1 | a Rosenquist, R4 aut |
| 700 | 1 | a de Sanjose, Su Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA.;Int Agcy Res Canc, F-69372 Lyon, France.4 aut |
| 700 | 1 | a Carracedo, Au Univ Santiago de Compostela, Grp Med Xenom, Ctr Nacl Genotipado CeGen ISCIII PRB2, CIBERER, Santiago De Compostela 15782, Spain.;King Abdulaziz Univ, CEGMR, Jeddah 21589, Saudi Arabia.4 aut |
| 700 | 1 | a Dyer, MJS4 aut |
| 700 | 1 | a Catovsky, Du Inst Canc Res, Div Mol Pathol, London SW7 3RP, England.4 aut |
| 700 | 1 | a Campo, Eu Hosp Clin Barcelona, Inst Invest Biomed August Pi ISunyer IDIBAPS, Barcelona 08036, Spain.;Univ Barcelona, Unitat Hematol, Hosp Clin, IDIBAPS, E-08036 Barcelona, Spain.4 aut |
| 700 | 1 | a Cerhan, JR4 aut |
| 700 | 1 | a Allan, JM4 aut |
| 700 | 1 | a Rothman, Nu NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.4 aut |
| 700 | 1 | a Houlston, R4 aut |
| 700 | 1 | a Slager, SLu Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA.4 aut |
| 710 | 2 | a Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.b NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.4 org |
| 773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 8, s. 14175-q 8<14175-x 2041-1723 |
| 856 | 4 | u https://www.nature.com/articles/ncomms14175.pdf |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1079678/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:135101399 |
| 856 | 4 8 | u https://doi.org/10.1038/ncomms14175 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-316933 |
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