Sökning: WFRF:(Hedberg Carola 1969) >
Molecular classific...
Molecular classification of spontaneous endometrial adenocarcinomas in BDII rats.
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- Samuelson, Emma, 1974 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institutionen för cell- och molekylärbiologi,Institute of Biomedicine, Department of Medical and Clinical Genetics,Department of Cell and Molecular Biology,University of Gothenburg
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- Hedberg, Carola, 1969 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Department of Cell and Molecular Biology,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg
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- Nilsson, Staffan, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology
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- Behboudi, Afrouz, 1967 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg
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(creator_code:org_t)
- 2009
- 2009
- Engelska.
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Ingår i: Endocrine-related cancer. - 1351-0088 .- 1479-6821. ; 16:1, s. 99-111
- Relaterad länk:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- Female rats of the BDII/Han inbred strain are prone to spontaneously develop endometrial carcinomas (EC) that in cell biology and pathogenesis are very similar to those of human. Human EC are classified into two major groups: Type I displays endometroid histology, is hormone-dependent, and characterized by frequent microsatellite instability and PTEN, K-RAS, and CTNNB1 (beta-Catenin) mutations; Type II shows non-endometrioid histology, is hormone-unrelated, displays recurrent TP53 mutation, CDKN2A (P16) inactivation, over-expression of ERBB2 (Her2/neu), and reduced CDH1 (Cadherin 1 or E-Cadherin) expression. However, many human EC have overlapping clinical, morphologic, immunohistochemical, and molecular features of types I and II. The EC developed in BDII rats can be related to type I tumors, since they are hormone-related and histologically from endometrioid type. Here, we combined gene sequencing (Pten, Ifr1, and Ctnnb1) and real-time gene expression analysis (Pten, Cdh1, P16, Erbb2, Ctnnb1, Tp53, and Irf1) to further characterize molecular alterations in this tumor model with respect to different subtypes of EC in humans. No mutation in Pten and Ctnnb1 was detected, whereas three tumors displayed sequence aberrations of the Irf1 gene. Significant down regulation of Pten, Cdh1, p16, Erbb2, and Ctnnb1 gene products was found in the tumors. In conclusion, our data suggest that molecular features of spontaneous EC in BDII rats can be related to higher-grade human type I tumors and thus, this model represents an excellent experimental tool for research on this malignancy in human.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Adenocarcinoma
- classification
- genetics
- Alleles
- Animals
- Cadherins
- genetics
- Cyclin-Dependent Kinase Inhibitor p16
- genetics
- Endometrial Neoplasms
- classification
- genetics
- Endometrium
- physiology
- Female
- Gene Expression Regulation
- Neoplastic
- Glycoproteins
- genetics
- Interferon Regulatory Factor-1
- genetics
- Male
- Mutation
- PTEN Phosphohydrolase
- genetics
- Rats
- Rats
- Inbred Strains
- Reverse Transcriptase Polymerase Chain Reaction
- Tumor Suppressor Protein p53
- genetics
- beta Catenin
- genetics
- genetics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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