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Bis 4,5-diazafluoren-9-one silver(I) nitrate: synthesis, X-ray structures, solution chemistry, hydrogel loading, DNA coupling and anti-bacterial screening

Massoud, Al-Shimaà A A, 1980 (author)
Chalmers tekniska högskola,Chalmers University of Technology
Gohar, Y. M. (author)
Alexandria University
Langer, Vratislav, 1949 (author)
Chalmers tekniska högskola,Chalmers University of Technology
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Lincoln, Per, 1958 (author)
Chalmers tekniska högskola,Chalmers University of Technology
Svensson, Frida, 1980 (author)
Chalmers tekniska högskola,Chalmers University of Technology
Janis, J. (author)
Itä-Suomen Yliopisto,University of Eastern Finland
Gårdebjer, Sofie, 1985 (author)
Chalmers tekniska högskola,Chalmers University of Technology,Mölnlycke healthcare
Haukka, M. (author)
Itä-Suomen Yliopisto,University of Eastern Finland
Jonsson, Fabian, 1983 (author)
Chalmers tekniska högskola,Chalmers University of Technology
Aneheim, Emma, 1982 (author)
Chalmers tekniska högskola,Chalmers University of Technology
Löwenhielm, Peter (author)
Mölnlycke healthcare
Abu-Youssef, Morsy A. M. (author)
Alexandria University
Öhrström, Lars, 1963 (author)
Chalmers tekniska högskola,Chalmers University of Technology
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 (creator_code:org_t)
Royal Society of Chemistry (RSC), 2011
2011
English.
In: New Journal of Chemistry. - : Royal Society of Chemistry (RSC). - 1369-9261 .- 1144-0546. ; 35:3, s. 640-648
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Synthesis of bis-4,5-diazafluoren-9-one silver(I) nitrate I (dafone = 4,5-diazafluoren-9-one) and the low temperature X-ray single crystal structure of [Ag(4,5-diazafluoren-9-one)2NO3], crystal form 1, and a re-determination of [Ag(4,5-diazafluoren-9-one)2]NO3 . H2O, crystal form 2 are presented. Crystal form 1 has a distorted trigonal planar coordination geometry around Ag(I) with an N-Ag-N bond angle of 123.45(7)o. Crystal form 2 has a perfect linear coordination around Ag, with N-Ag-N 180.0o. Compound I was characterized by 1H-NMR, biological activity and ESI-MS in DMSO at room temperature. The biological activity was determined against 6 different resistant clinical isolates; two Gram-positive (Staphylococcus aureus and Streptococcus pyogenes) and four Gram-negative (Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus mirabilis, and Salmonella sp.) in comparison with 15 known antibiotics used in the treatment of diabetic foot infections. Compound I showed broad spectrum activity against all the test organisms. P. mirabilis and S. aureus and K. pneumoniae were the most sensitive clinical isolates (MIC = 4, 6 and 4 μg ml-1, respectively). Three different hydrogels containing I or Ag2SO4 were prepared and the antimicrobial activity against Ps. aeruginosa (ATCC 15442) compared, showing more or less equal activity on a weight basis, but I seems to have a significant better performance per silver ion. The Ag(I) complex also binds more effectively to calf thymus DNA than the dafone ligand itself.

Subject headings

NATURVETENSKAP  -- Kemi (hsv//swe)
NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)

Keyword

zn-ii
bonding complexes
metal-complexes
fe-iii
deoxyribonucleic acid
crystal-structures
cu-ii
ag-i
antimicrobial activity
ag(i) complexes

Publication and Content Type

art (subject category)
ref (subject category)

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