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Sökning: WFRF:(Luo B.) > (2020-2024) > A non-invasive 25-G...

  • Guo, JinanJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Urol, Shenzhen, Peoples R China.;Shenzhen Peoples Hosp, Shenzhen Clin Res Ctr Geriatr, Shenzhen, Peoples R China.;Shenzhen Urol Minimally Invas Engn Ctr, Shenzhen, Peoples R China.,Department of Urology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University), Shenzhen, China; Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People’s Hospital, Shenzhen, China; Shenzhen Urology Minimally Invasive Engineering Center, Shenzhen, China; Shenzhen Public Service Platform on Tumor Precision Medicine and Molecular Diagnosis, Clinical Medicine Research Centre, Shenzhen, China; The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, China (författare)

A non-invasive 25-Gene PLNM-Score urine test for detection of prostate cancer pelvic lymph node metastasis

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • 2024
  • Nature Publishing Group,2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:mau-66111
  • https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-66111URI
  • https://doi.org/10.1038/s41391-023-00758-zDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-221011URI
  • https://lup.lub.lu.se/record/198bad21-c863-4219-b2a2-f5a89ab95ca2URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Prostate cancer patients with pelvic lymph node metastasis (PLNM) have poor prognosis. Based on EAU guidelines, patients with >5% risk of PLNM by nomograms often receive pelvic lymph node dissection (PLND) during prostatectomy. However, nomograms have limited accuracy, so large numbers of false positive patients receive unnecessary surgery with potentially serious side effects. It is important to accurately identify PLNM, yet current tests, including imaging tools are inaccurate. Therefore, we intended to develop a gene expression-based algorithm for detecting PLNM. Methods: An advanced random forest machine learning algorithm screening was conducted to develop a classifier for identifying PLNM using urine samples collected from a multi-center retrospective cohort (n = 413) as training set and validated in an independent multi-center prospective cohort (n = 243). Univariate and multivariate discriminant analyses were performed to measure the ability of the algorithm classifier to detect PLNM and compare it with the Memorial Sloan Kettering Cancer Center (MSKCC) nomogram score. Results: An algorithm named 25 G PLNM-Score was developed and found to accurately distinguish PLNM and non-PLNM with AUC of 0.93 (95% CI: 0.85-1.01) and 0.93 (95% CI: 0.87-0.99) in the retrospective and prospective urine cohorts respectively. Kaplan-Meier plots showed large and significant difference in biochemical recurrence-free survival and distant metastasis-free survival in the patients stratified by the 25 G PLNM-Score (log rank P < 0.001 and P < 0.0001, respectively). It spared 96% and 80% of unnecessary PLND with only 0.51% and 1% of PLNM missing in the retrospective and prospective cohorts respectively. In contrast, the MSKCC score only spared 15% of PLND with 0% of PLNM missing. Conclusions: The novel 25 G PLNM-Score is the first highly accurate and non-invasive machine learning algorithm-based urine test to identify PLNM before PLND, with potential clinical benefits of avoiding unnecessary PLND and improving treatment decision-making.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Gu, LiangyouChinese Peoples Liberat Army PLA Gen Hosp, Med Ctr 3, Dept Urol, Beijing, Peoples R China.,Department of Urology, The Third Medical Centre, Chinese PLA General Hospital, Beijing, China,General Hospital of People's Liberation Army (författare)
  • Johnson, HeatherOlympia Diagnost Inc, Sunnyvale, CA USA.,Olympia Diagnostics, Inc., CA, Sunnyvale, United States,Biogen, Inc. (författare)
  • Gu, DiGuangzhou Med Univ, Affiliated Hosp 1, Dept Urol, Guangzhou, Peoples R China.,Department of Urology, The First affiliated Hospital of Guangzhou Medical University, Guangzhou, China (författare)
  • Lu, ZhenquanUniv Hong Kong, Shenzhen Hosp, Shenzhen, Peoples R China.,The University of Hong Kong-Shenzhen Hospital, Shenzhen, China (författare)
  • Luo, BinfengUniv Hong Kong, Shenzhen Hosp, Shenzhen, Peoples R China.,The University of Hong Kong-Shenzhen Hospital, Shenzhen, China (författare)
  • Yuan, QianJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Urol, Shenzhen, Peoples R China.;Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Peoples Hosp, Shenzhen, Peoples R China.,Department of Urology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University), Shenzhen, China; The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, China (författare)
  • Zhang, XuhuiInst Basic Med Sci, Dept Biodiag, Beijing, Peoples R China.,Department of Bio-diagnosis, Institute of Basic Medical Sciences, Beijing, China (författare)
  • Xia, TaolinFirst Peoples Hosp Foshan, Dept Urol, Foshan, Peoples R China.,Department of Urology, Foshan First People’s Hospital, Foshan, China (författare)
  • Zeng, QingsongSun Yat Sen Univ, Affiliated Hosp 1, Dept Urol, Guangzhou, Peoples R China.,Department of Urology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China (författare)
  • Wu, Alan H. B.San Francisco Gen Hosp, Clin Labs, San Francisco, CA USA.,Clinical Laboratories, San Francisco General Hospital, CA, San Francisco, United States (författare)
  • Johnson, AllanKinet Real, Santa Clara, CA USA.,Kinetic Reality, Santa Clara, United States (författare)
  • Dizeyi, NishtmanLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Urologi, Malmö (Abrahamsson),Forskargrupper vid Lunds universitet,Molekylärgenetisk reproduktionsmedicin, Malmö,Department of Translational Medicine,Faculty of Medicine,Urological research, Malmö,Lund University Research Groups,Molecular genetic reproductive medicine, Malmö(Swepub:lu)kir-dni (författare)
  • Abrahamsson, Per AndersLund University,Lunds universitet,Urologi, Malmö (Abrahamsson),Forskargrupper vid Lunds universitet,Urological research, Malmö,Lund University Research Groups(Swepub:lu)uro-paa (författare)
  • Zhang, HeqiuInst Basic Med Sci, Dept Biodiag, Beijing, Peoples R China.,Department of Bio-diagnosis, Institute of Basic Medical Sciences, Beijing, China (författare)
  • Chen, LingwuSun Yat Sen Univ, Affiliated Hosp 1, Dept Urol, Guangzhou, Peoples R China.,Department of Urology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China (författare)
  • Xiao, KefengJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Urol, Shenzhen, Peoples R China.;Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Peoples Hosp, Shenzhen, Peoples R China.,Department of Urology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University), Shenzhen, China; The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, China (författare)
  • Zou, ChangJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Urol, Shenzhen, Peoples R China.;Shenzhen Urol Minimally Invas Engn Ctr, Shenzhen, Peoples R China.;Jinan Univ, Shenzhen Peoples Hosp, Shenzhen Publ Serv Platform Tumor Precis Med & Mol, Clin Med Coll 2, Shenzhen, Peoples R China.;Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Peoples Hosp, Shenzhen, Peoples R China.;Southwest Med Univ, Sch Pharm, Key Lab Med Electrophysiol, Educ Minist, Luzhou, Peoples R China.,Department of Urology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University), Shenzhen, China; Shenzhen Urology Minimally Invasive Engineering Center, Shenzhen, China; Shenzhen Public Service Platform on Tumor Precision Medicine and Molecular Diagnosis, Clinical Medicine Research Centre, Shenzhen, China; The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, China; Key Laboratory of Medical Electrophysiology of Education Ministry, School of Pharmacy, Southwest Medical University, Luzhou, China (författare)
  • Persson, Jenny L.,ProfessorUmeå University,Malmö University,Umeå universitet,Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Umeå Univ, Dept Mol Biol, Umeå, Sweden.,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Biomedical Sciences, Malmö University, Malmö, Sweden(Swepub:umu)jepe0128 (författare)
  • Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Urol, Shenzhen, Peoples R China.;Shenzhen Peoples Hosp, Shenzhen Clin Res Ctr Geriatr, Shenzhen, Peoples R China.;Shenzhen Urol Minimally Invas Engn Ctr, Shenzhen, Peoples R China.Department of Urology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University), Shenzhen, China; Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People’s Hospital, Shenzhen, China; Shenzhen Urology Minimally Invasive Engineering Center, Shenzhen, China; Shenzhen Public Service Platform on Tumor Precision Medicine and Molecular Diagnosis, Clinical Medicine Research Centre, Shenzhen, China; The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, China (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Prostate Cancer and Prostatic Diseases: Nature Publishing Group1365-78521476-5608

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