Sökning: WFRF:(Malin S) > (2015-2019) > Potential roles of ...
Fältnamn | Indikatorer | Metadata |
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000 | 04758naa a2200757 4500 | |
001 | oai:gup.ub.gu.se/283650 | |
003 | SwePub | |
008 | 240528s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2836502 URI |
024 | 7 | a https://doi.org/10.1038/s41586-019-1443-52 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Blacher, E.4 aut |
245 | 1 0 | a Potential roles of gut microbiome and metabolites in modulating ALS in mice |
264 | c 2019-07-22 | |
264 | 1 | b Springer Science and Business Media LLC,c 2019 |
520 | a Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder, in which the clinical manifestations may be influenced by genetic and unknown environmental factors. Here we show that ALS-prone Sod1 transgenic (Sod1-Tg) mice have a pre-symptomatic, vivarium-dependent dysbiosis and altered metabolite configuration, coupled with an exacerbated disease under germ-free conditions or after treatment with broad-spectrum antibiotics. We correlate eleven distinct commensal bacteria at our vivarium with the severity of ALS in mice, and by their individual supplementation into antibiotic-treated Sod1-Tg mice we demonstrate that Akkermansia muciniphila (AM) ameliorates whereas Ruminococcus torques and Parabacteroides distasonis exacerbate the symptoms of ALS. Furthermore, Sod1-Tg mice that are administered AM are found to accumulate AM-associated nicotinamide in the central nervous system, and systemic supplementation of nicotinamide improves motor symptoms and gene expression patterns in the spinal cord of Sod1-Tg mice. In humans, we identify distinct microbiome and metabolite configurations-including reduced levels of nicotinamide systemically and in the cerebrospinal fluid-in a small preliminary study that compares patients with ALS with household controls. We suggest that environmentally driven microbiome-brain interactions may modulate ALS in mice, and we call for similar investigations in the human form of the disease. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
653 | a transgenic mouse model | |
653 | a alignment | |
653 | a nrf-1 | |
653 | a degeneration | |
653 | a protects | |
653 | a genes | |
653 | a Science & Technology - Other Topics | |
700 | 1 | a Bashiardes, S.4 aut |
700 | 1 | a Shapiro, H.4 aut |
700 | 1 | a Rothschild, D.4 aut |
700 | 1 | a Mor, U.4 aut |
700 | 1 | a Dori-Bachash, M.4 aut |
700 | 1 | a Kleimeyer, C.4 aut |
700 | 1 | a Moresi, C.4 aut |
700 | 1 | a Harnik, Y.4 aut |
700 | 1 | a Zur, M.4 aut |
700 | 1 | a Zabari, M.4 aut |
700 | 1 | a Brik, R. B. Z.4 aut |
700 | 1 | a Kviatcovsky, D.4 aut |
700 | 1 | a Zmora, N.4 aut |
700 | 1 | a Cohen, Y.4 aut |
700 | 1 | a Bar, N.4 aut |
700 | 1 | a Levi, I.4 aut |
700 | 1 | a Amar, N.4 aut |
700 | 1 | a Mehlman, T.4 aut |
700 | 1 | a Brandis, A.4 aut |
700 | 1 | a Biton, I.4 aut |
700 | 1 | a Kuperman, Y.4 aut |
700 | 1 | a Tsoory, M.4 aut |
700 | 1 | a Alfahel, L.4 aut |
700 | 1 | a Harmelin, A.4 aut |
700 | 1 | a Schwartz, M.4 aut |
700 | 1 | a Israelson, A.4 aut |
700 | 1 | a Arike, Liisau Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology4 aut0 (Swepub:gu)xarili |
700 | 1 | a Johansson, Malin E V,d 1971u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology4 aut0 (Swepub:gu)xjomal |
700 | 1 | a Hansson, Gunnar C.,d 1951u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology4 aut0 (Swepub:gu)xhagun |
700 | 1 | a Gotkine, M.4 aut |
700 | 1 | a Segal, E.4 aut |
700 | 1 | a Elinav, E.4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi4 org |
773 | 0 | t Natured : Springer Science and Business Media LLCg 572:7770q 572:7770x 0028-0836x 1476-4687 |
856 | 4 | u https://zenodo.org/record/5747629/files/2019%20ALS%20accepted%20open%20access.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/283650 |
856 | 4 8 | u https://doi.org/10.1038/s41586-019-1443-5 |
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