Sökning: WFRF:(Särndahl Eva 1963 ) >
Lower activation of...
Lower activation of caspase-1 by Staphylococcus epidermidis isolated from prosthetic joint infections compared to commensals
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- Månsson, Emeli, 1978- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Centre for Clinical Research, Hospital of Västmanland Västerås, Region Västmanland, Västerås, Sweden; Centre for Clinical Research, Hospital of Västmanland Västerås, Uppsala University, Västerås, Sweden,iRiSC - Inflammatory Response and Infection Susceptibility Centre,School of Medical Science, Inflammatory Response and Infection Susceptibility Centre, Uppsala University, Hospital of Västmanland, Västerås, Sweden
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- Sahdo, Berolla, 1984- (författare)
- Inflammatory Response and Infection Susceptibility Centre, Örebro University, Örebro, Sweden,iRiSC - Inflammatory Response and Infection Susceptibility Centre
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- Nilsdotter-Augustinsson, Åsa (författare)
- Linköpings universitet,Medicinska fakulteten,Avdelningen för mikrobiologi och molekylär medicin,Region Östergötland, Infektionskliniken i Östergötland
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- Särndahl, Eva, 1963- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,School of Medical Sciences, iRiSC - Inflammatory Response and Infection Susceptibility Centre, Örebro University, Örebro, Sweden
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- Söderquist, Bo, 1955- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,School of Medical Sciences, Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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(creator_code:org_t)
- 2018-01-13
- 2018
- Engelska.
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Ingår i: Journal of bone and joint infection. - : IVYSPRING. - 2206-3552. ; 3:1, s. 10-14
- Relaterad länk:
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https://doi.org/10.7...
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http://www.jbji.net/...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.7...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Nosocomial sequence types of Staphylococcus epidermidis dominate in prosthetic joint infections. We examined caspase-1 activation in human neutrophils after incubation with Staphylococcus epidermidis isolated from prosthetic joint infections and normal skin flora. Active caspase-1 was lower after incubation with isolates from prosthetic joint infections than after incubation with commensal isolates. Both host and isolate dependent differences in active caspase-1 were noted. Our results indicate that there might be a host-dependent incapacity to elicit a strong caspase-1 response towards certain strains of S. epidermidis. Further experiments with a larger number of individuals are warranted.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Staphylococcus epidermidis
- caspase-1
- neutrophils
- prosthetic joint infections
- host-pathogen interaction
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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