Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals

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Fältnamn	Indikatorer	Metadata
000		07488naa a2201621 4500
001		oai:DiVA.org:uu-196970
003		SwePub
008		130315s2012 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1969702 URI
024	7	a https://doi.org/10.1371/journal.pgen.10026072 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Dastani, Zari4 aut
245	1 0	a Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits :b A Multi-Ethnic Meta-Analysis of 45,891 Individuals
264		c 2012-03-29
264	1	b Public Library of Science (PLoS),c 2012
338		a print2 rdacarrier
500		a Group Author(s): DIAGRAM Consortium ; MAGIC Consortium ; GLGC Investigators ; MuTHER ConsortiumAnn-Christine Syvänen (Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper) is a member of the MAGIC ConsortiumFor complete list of Consortia Authors see http://dx.doi.org/10.1371/journal.pgen.1002607
520		a Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P=4.5 x 10(-8)-1.2 x 10(-43)). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p<3 x 10(-4)). We next developed a multi-SNP genotypic risk score to test the association of adiponectin decreasing risk alleles on metabolic traits and diseases using consortia-level meta-analytic data. This risk score was associated with increased risk of T2D (p=4.3 x 10(-3), n = 22,044), increased triglycerides (p=2.6 x 10(-14), n = 93,440), increased waist-to-hip ratio (p=1.8 x 10(-5), n = 77,167), increased glucose two hours post oral glucose tolerance testing (p=4.4 x 10(-3), n = 15,234), increased fasting insulin (p = 0.015, n = 48,238), but with lower in HDL-cholesterol concentrations (p=4.5x10(-13), n = 96,748) and decreased BMI (p= 1.4 x 10(-14), n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance.
700	1	a Hivert, Marie-France4 aut
700	1	a Timpson, Nicholas4 aut
700	1	a Perry, John R. B.4 aut
700	1	a Yuan, Xin4 aut
700	1	a Scott, Robert A.4 aut
700	1	a Henneman, Peter4 aut
700	1	a Heid, Iris M.4 aut
700	1	a Kizer, Jorge R.4 aut
700	1	a Lyytikainen, Leo-Pekka4 aut
700	1	a Fuchsberger, Christian4 aut
700	1	a Tanaka, Toshiko4 aut
700	1	a Morris, Andrew P.4 aut
700	1	a Small, Kerrin4 aut
700	1	a Isaacs, Aaron4 aut
700	1	a Beekman, Marian4 aut
700	1	a Coassin, Stefan4 aut
700	1	a Lohman, Kurt4 aut
700	1	a Qi, Lu4 aut
700	1	a Kanoni, Stavroula4 aut
700	1	a Pankow, James S.4 aut
700	1	a Uh, Hae-Won4 aut
700	1	a Wu, Ying4 aut
700	1	a Bidulescu, Aurelian4 aut
700	1	a Rasmussen-Torvik, Laura J.4 aut
700	1	a Greenwood, Celia M. T.4 aut
700	1	a Ladouceur, Martin4 aut
700	1	a Grimsby, Jonna4 aut
700	1	a Manning, Alisa K.4 aut
700	1	a Liu, Ching-Ti4 aut
700	1	a Kooner, Jaspal4 aut
700	1	a Mooser, Vincent E.4 aut
700	1	a Vollenweider, Peter4 aut
700	1	a Kapur, Karen A.4 aut
700	1	a Chambers, John4 aut
700	1	a Wareham, Nicholas J.4 aut
700	1	a Langenberg, Claudia4 aut
700	1	a Frants, Rune4 aut
700	1	a Willems-vanDijk, Ko4 aut
700	1	a Oostra, Ben A.4 aut
700	1	a Willems, Sara M.4 aut
700	1	a Lamina, Claudia4 aut
700	1	a Winkler, Thomas W.4 aut
700	1	a Psaty, Bruce M.4 aut
700	1	a Tracy, Russell P.4 aut
700	1	a Brody, Jennifer4 aut
700	1	a Chen, Ida4 aut
700	1	a Viikari, Jorma4 aut
700	1	a Kahonen, Mika4 aut
700	1	a Pramstaller, Peter P.4 aut
700	1	a Evans, David M.4 aut
700	1	a St Pourcain, Beate4 aut
700	1	a Sattar, Naveed4 aut
700	1	a Wood, Andrew R.4 aut
700	1	a Bandinelli, Stefania4 aut
700	1	a Carlson, Olga D.4 aut
700	1	a Egan, Josephine M.4 aut
700	1	a Bohringer, Stefan4 aut
700	1	a van Heemst, Diana4 aut
700	1	a Kedenko, Lyudmyla4 aut
700	1	a Kristiansson, Kati4 aut
700	1	a Nuotio, Marja-Liisa4 aut
700	1	a Loo, Britt-Marie4 aut
700	1	a Harris, Tamara4 aut
700	1	a Garcia, Melissa4 aut
700	1	a Kanaya, Alka4 aut
700	1	a Haun, Margot4 aut
700	1	a Klopp, Norman4 aut
700	1	a Wichmann, H. -Erich4 aut
700	1	a Deloukas, Panos4 aut
700	1	a Katsareli, Efi4 aut
700	1	a Couper, David J.4 aut
700	1	a Duncan, Bruce B.4 aut
700	1	a Kloppenburg, Margreet4 aut
700	1	a Adair, Linda S.4 aut
700	1	a Borja, Judith B.4 aut
700	1	a Wilson, James G.4 aut
700	1	a Musani, Solomon4 aut
700	1	a Guo, Xiuqing4 aut
700	1	a Johnson, Toby4 aut
700	1	a Semple, Robert4 aut
700	1	a Teslovich, Tanya M.4 aut
700	1	a Allison, Matthew A.4 aut
700	1	a Redline, Susan4 aut
700	1	a Buxbaum, Sarah G.4 aut
700	1	a Mohlke, Karen L.4 aut
700	1	a Meulenbelt, Ingrid4 aut
700	1	a Ballantyne, Christie M.4 aut
700	1	a Dedoussis, George V.4 aut
700	1	a Hu, Frank B.4 aut
700	1	a Liu, Yongmei4 aut
700	1	a Paulweber, Bernhard4 aut
700	1	a Spector, Timothy D.4 aut
700	1	a Slagboom, P. Eline4 aut
700	1	a Ferrucci, Luigi4 aut
700	1	a Jula, Antti4 aut
700	1	a Perola, Markus4 aut
700	1	a Raitakari, Olli4 aut
700	1	a Florez, Jose C.4 aut
700	1	a Salomaa, Veikko4 aut
700	1	a Eriksson, Johan G.4 aut
700	1	a Frayling, Timothy M.4 aut
700	1	a Hicks, Andrew A.4 aut
700	1	a Lehtimaki, Terho4 aut
700	1	a Smith, George Davey4 aut
700	1	a Siscovick, David S.4 aut
700	1	a Kronenberg, Florian4 aut
700	1	a van Duijn, Cornelia4 aut
700	1	a Loos, Ruth J. F.4 aut
700	1	a Waterworth, Dawn M.4 aut
700	1	a Meigs, James B.4 aut
700	1	a Dupuis, Josee4 aut
700	1	a Richards, J. Brent4 aut
773	0	t PLOS Geneticsd : Public Library of Science (PLoS)g 8:3, s. e1002607-q 8:3<e1002607-x 1553-7390x 1553-7404
856	4	u https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002607&type=printable
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-196970
856	4 8	u https://doi.org/10.1371/journal.pgen.1002607

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Av författaren/redakt...: Dastani, Zari; Hivert, Marie-Fr ...; Timpson, Nichola ...; Perry, John R. B ...; Yuan, Xin; Scott, Robert A.; visa fler...; Henneman, Peter; Heid, Iris M.; Kizer, Jorge R.; Lyytikainen, Leo ...; Fuchsberger, Chr ...; Tanaka, Toshiko; Morris, Andrew P ...; Small, Kerrin; Isaacs, Aaron; Beekman, Marian; Coassin, Stefan; Lohman, Kurt; Qi, Lu; Kanoni, Stavroul ...; Pankow, James S.; Uh, Hae-Won; Wu, Ying; Bidulescu, Aurel ...; Rasmussen-Torvik ...; Greenwood, Celia ...; Ladouceur, Marti ...; Grimsby, Jonna; Manning, Alisa K ...; Liu, Ching-Ti; Kooner, Jaspal; Mooser, Vincent ...; Vollenweider, Pe ...; Kapur, Karen A.; Chambers, John; Wareham, Nichola ...; Langenberg, Clau ...; Frants, Rune; Willems-vanDijk, ...; Oostra, Ben A.; Willems, Sara M.; Lamina, Claudia; Winkler, Thomas ...; Psaty, Bruce M.; Tracy, Russell P ...; Brody, Jennifer; Chen, Ida; Viikari, Jorma; Kahonen, Mika; Pramstaller, Pet ...; Evans, David M.; St Pourcain, Bea ...; Sattar, Naveed; Wood, Andrew R.; Bandinelli, Stef ...; Carlson, Olga D.; Egan, Josephine ...; Bohringer, Stefa ...; van Heemst, Dian ...; Kedenko, Lyudmyl ...; Kristiansson, Ka ...; Nuotio, Marja-Li ...; Loo, Britt-Marie; Harris, Tamara; Garcia, Melissa; Kanaya, Alka; Haun, Margot; Klopp, Norman; Wichmann, H. -Er ...; Deloukas, Panos; Katsareli, Efi; Couper, David J.; Duncan, Bruce B.; Kloppenburg, Mar ...; Adair, Linda S.; Borja, Judith B.; Wilson, James G.; Musani, Solomon; Guo, Xiuqing; Johnson, Toby; Semple, Robert; Teslovich, Tanya ...; Allison, Matthew ...; Redline, Susan; Buxbaum, Sarah G ...; Mohlke, Karen L.; Meulenbelt, Ingr ...; Ballantyne, Chri ...; Dedoussis, Georg ...; Hu, Frank B.; Liu, Yongmei; Paulweber, Bernh ...; Spector, Timothy ...; Slagboom, P. Eli ...; Ferrucci, Luigi; Jula, Antti; Perola, Markus; Raitakari, Olli; Florez, Jose C.; Salomaa, Veikko; Eriksson, Johan ...; Frayling, Timoth ...; Hicks, Andrew A.; Lehtimaki, Terho; Smith, George Da ...; Siscovick, David ...; Kronenberg, Flor ...; van Duijn, Corne ...; Loos, Ruth J. F.; Waterworth, Dawn ...; Meigs, James B.; Dupuis, Josee; Richards, J. Bre ...; visa färre...

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