WFRF:(Vollset Stein E)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03343naa a2200373 4500 | |
| 001 | oai:DiVA.org:umu-118200 | |
| 003 | SwePub | |
| 008 | 160314s2007 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1182002 URI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Midttun, Öivind4 aut |
| 245 | 1 0 | a Plasma vitamin B-6 forms and their relation to transsulfuration metabolites in a large, population-based study |
| 264 | 1 | a Bethesda :b American society for nutrition,c 2007 |
| 338 | a print2 rdacarrier | |
| 520 | a Background: Vitamin B-6 exists in different forms; one of those forms, pyridoxal 5'-phosphate (PLP), serves a cofactor in many enzyme reactions, including the transsulfuration pathway, in which homocysteine is converted to cystathionine and then to cysteine. Data on the relations between indexes of vitamin B-6 status and transsulfuration metabolites in plasma are sparse and conflicting.Objective: We investigated the distribution and associations of various vitamin B-6 species in plasma and their relation to plasma concentrations of transsulfuration metabolites.Design: Nonfasting blood samples from 10 601 healthy subjects with a mean age of 56.4 y were analyzed for all known vitamin B-6 vitamers, folate, cobalamin, riboflavin, total homocysteine, cystathionine, total cysteine, methionine, and creatinine. All subjects were genotyped for the methylenetetrahydrofolate reductase (MTHFR) 677C -> T polymorphism.Results: Plasma concentrations of the main vitamin B-6 vitamers-PLP, pyridoxal, and 4-pyridoxic acid-were strongly correlated. Among the vitamin B-6 vitamers, PLP showed the strongest and most consistent inverse relation to total homocysteine and cystathionine, but the dose response was different for the 2 metabolites. The PLP-total homocysteine relation was significant only in the lowest quartile of the vitamin B-6 distribution and was strongest in subjects with the MTHFR 677TT genotype, whereas cystathionine showed a graded response throughout the range of vitamin B-6 vitamer concentrations, and the effect was not modified by the MTHFR 677C -> T genotype.Conclusion: This large population-based study provided precise estimates of the relation between plasma concentrations of vitamin B-6 forms and transsulfuration metabolites as modified by the MTHFR 677C -> T genotype. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
| 653 | a vitamin B-6 | |
| 653 | a homocysteine | |
| 653 | a cystathionine | |
| 653 | a cysteine | |
| 653 | a methylenetetrahydrofolate reductase | |
| 653 | a trans sulfuration | |
| 700 | 1 | a Hustad, Steinar4 aut |
| 700 | 1 | a Schneede, Jörnu Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)josc0012 |
| 700 | 1 | a Vollset, Stein E4 aut |
| 700 | 1 | a Ueland, Per M4 aut |
| 710 | 2 | a Umeå universitetb Klinisk kemi4 org |
| 773 | 0 | t American Journal of Clinical Nutritiond Bethesda : American society for nutritiong 86:1, s. 131-138q 86:1<131-138x 0002-9165x 1938-3207 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-118200 |
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