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The role of brain i...
The role of brain integrity in the association between occupational complexity and cognitive performance in subjects with increased risk of dementia
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- Rydstrom, Anders (författare)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Karolinska Institutet, Sweden,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Ctr Alzheimer Res, Stockholm, Sweden.;Karolinska Inst, Dept Neurobiol Care Sci & Soc, Aging Res Ctr, Ctr Alzheimer Res, Stockholm, Sweden.;Stockholm Univ, Stockholm, Sweden.
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- Stephen, Ruth (författare)
- Univ Eastern Finland, Inst Clin Med, Dept Neurol, Kuopio, Finland.
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- Kåreholt, Ingemar, 1960- (författare)
- Stockholms universitet,Jönköping University,HHJ, Institutet för gerontologi,HHJ. ARN-J (Aging Research Network - Jönköping),Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden; Aging Research Center, Department of Neurobiology, Center for Alzheimer Research, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Karolinska Institutet, Stockholm, Sweden; Jönköping University, Jönköping, Sweden
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- Mattsson, Alexander Darin (författare)
- Karolinska Inst, Dept Neurobiol Care Sci & Soc, Aging Res Ctr, Ctr Alzheimer Res, Stockholm, Sweden.;Stockholm Univ, Stockholm, Sweden.
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- Ngandu, Tiia (författare)
- Karolinska Institutet
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- Lehtisalo, Jenni (författare)
- Univ Eastern Finland, Inst Clin Med, Dept Neurol, Kuopio, Finland.;Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Populat Hlth, Helsinki, Finland.
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- Backman, Lars (författare)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Karolinska Inst, Dept Neurobiol Care Sci & Soc, Aging Res Ctr, Ctr Alzheimer Res, Stockholm, Sweden.;Stockholm Univ, Stockholm, Sweden.
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- Kemppainen, Nina (författare)
- Turku Univ Hosp, Div Clin Neurosci, Turku, Finland.;Turku Univ Hosp, Turku PET Ctr, Turku, Finland.
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- Rinne, Juha (författare)
- Turku Univ Hosp, Turku PET Ctr, Turku, Finland.;Univ Turku, InFLAMES Res Flagship Ctr, Turku, Finland.
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- Sindi, Shireen (författare)
- Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Ctr Alzheimer Res, Stockholm, Sweden.;Imperial Coll London, Sch Publ Hlth, Ageing Epidemiol Res Unit, London, England.
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- Soininen, Hilkka (författare)
- Univ Eastern Finland, Inst Clin Med, Dept Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Neuroctr Neurol, Kuopio, Finland.
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- Vanninen, Ritva (författare)
- Kuopio Univ Hosp, Diagnost Imaging Ctr, Dept Clin Radiol, Kuopio, Finland.;Univ Eastern Finland, Inst Clin Med, Unit Radiol, Kuopio, Finland.
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- Solomon, Alina (författare)
- Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Ctr Alzheimer Res, Stockholm, Sweden.;Univ Eastern Finland, Inst Clin Med, Dept Neurol, Kuopio, Finland.;Imperial Coll London, Sch Publ Hlth, Ageing Epidemiol Res Unit, London, England.
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- Mangialasche, Francesca (författare)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Ctr Alzheimer Res, Stockholm, Sweden.;Karolinska Inst, Dept Neurobiol Care Sci & Soc, Aging Res Ctr, Ctr Alzheimer Res, Stockholm, Sweden.;Stockholm Univ, Stockholm, Sweden.
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(creator_code:org_t)
- S. Karger, 2023
- 2023
- Engelska.
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Ingår i: Gerontology. - : S. Karger. - 0304-324X .- 1423-0003. ; 69:8, s. 972-985
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Introduction: Mechanisms underlying the positive association between occupational mental demands and late-life cognition are poorly understood. The objective of this study was to assess whether the association between occupational complexity and cognition is related to and moderated by brain integrity in individuals at-risk for dementia. Brain integrity was appraised throughout structural measures (Magnetic Resonance Imaging, MRI) and amyloid accumulation (Pittsburgh Compound B (PiB)-positron emission tomography, PiB-PET).Methods: Participants from the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) neuroimaging sample -MRI (N=126), PiB-PET (N=41)- were included in a post-hoc cross-sectional analysis. Neuroimaging parameters comprised the Alzheimer ' s Disease signature cortical thickness (ADS, Freesurfer 5.3), medial temporal atrophy (MTA), and amyloid accumulation (PiB-PET). Cognition was assessed using the Neuropsychological Test Battery. Occupational complexity with data, people, and substantive complexity were classified through the Dictionary of Occupational Titles. Linear regression models included cognition as dependent variable, occupational complexity, measures of brain integrity, and their interaction terms as predictors.Results: Occupational complexity with data and substantive complexity were associated with better cognition (overall cognition, executive function) when adjusting for ADS and MTA (independent association). Significant interaction effects between occupational complexity and brain integrity were also found, indicating that, for some indicators of brain integrity and cognition (e.g., overall cognition, processing speed), the positive association between occupational complexity and cognition occurred only among persons with higher brain integrity (moderated association).Conclusion: Among individuals at-risk for dementia, occupational complexity does not seem to contribute towards resilience against neuropathology. These exploratory findings require validation in larger populations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Nyckelord
- Aging
- Alzheimer’s disease
- Amyloid
- Cognition
- Lifestyle
- Mental stimulation
- Neuropathology
- Occupational complexity
- Prevention
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Rydstrom, Anders
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Stephen, Ruth
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Kåreholt, Ingema ...
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Mattsson, Alexan ...
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Ngandu, Tiia
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Lehtisalo, Jenni
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visa fler...
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Backman, Lars
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Kemppainen, Nina
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Rinne, Juha
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Sindi, Shireen
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Soininen, Hilkka
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Vanninen, Ritva
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Solomon, Alina
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Mangialasche, Fr ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Geriatrik
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Annan medicin oc ...
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och Gerontologi medi ...
- Artiklar i publikationen
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Gerontology
- Av lärosätet
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Jönköping University
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Stockholms universitet
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Karolinska Institutet