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WFRF:(Irwin David J)
 

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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004716naa a2200553 4500
001oai:lup.lub.lu.se:15827055-3461-44c7-a0ac-1a4f70e40f3e
003SwePub
008221202s2022 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/15827055-3461-44c7-a0ac-1a4f70e40f3e2 URI
0247 a https://doi.org/10.3233/JAD-2157282 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Dominguez Perez, Sophiau University of Connecticut,University of Pennsylvania4 aut
2451 0a Neuropsychological and Neuroanatomical Features of Patients with Behavioral/Dysexecutive Variant Alzheimer's Disease (AD) : A Comparison to Behavioral Variant Frontotemporal Dementia and Amnestic AD Groups
264 1c 2022
300 a 18 s.
520 a Background: An understudied variant of Alzheimer's disease (AD), the behavioral/dysexecutive variant of AD (bvAD), is associated with progressive personality, behavior, and/or executive dysfunction and frontal atrophy. Objective: This study characterizes the neuropsychological and neuroanatomical features associated with bvAD by comparing it to behavioral variant frontotemporal dementia (bvFTD), amnestic AD (aAD), and subjects with normal cognition. Methods: Subjects included 16 bvAD, 67 bvFTD, 18 aAD patients, and 26 healthy controls. Neuropsychological assessment and MRI data were compared between these groups. Results: Compared to bvFTD, bvAD showed more significant visuospatial impairments (Rey Figure copy and recall), more irritability (Neuropsychological Inventory), and equivalent verbal memory (Philadelphia Verbal Learning Test). Compared to aAD, bvAD indicated more executive dysfunction (F-letter fluency) and better visuospatial performance. Neuroimaging analysis found that bvAD showed cortical thinning relative to bvFTD posteriorly in left temporal-occipital regions; bvFTD had cortical thinning relative to bvAD in left inferior frontal cortex. bvAD had cortical thinning relative to aAD in prefrontal and anterior temporal regions. All patient groups had lower volumes than controls in both anterior and posterior hippocampus. However, bvAD patients had higher average volume than aAD patients in posterior hippocampus and higher volume than bvFTD patients in anterior hippocampus after adjustment for age and intracranial volume. Conclusion: Findings demonstrated that underlying pathology mediates disease presentation in bvAD and bvFTD.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653 a Alzheimer's disease
653 a behavioral
653 a behavioral variant frontotemporal dementia
653 a cognitive domains
653 a cortical thinning
653 a frontal variant
653 a hippocampal volumes
653 a neuropsychiatric symptoms
7001 a Phillips, Jeffrey S.u University of Pennsylvania4 aut
7001 a Norise, Catherineu University of Pennsylvania4 aut
7001 a Kinney, Nikolas G.u University of Pennsylvania4 aut
7001 a Vaddi, Preranau University of Pennsylvania4 aut
7001 a Halpin, Amyu University of Pennsylvania,University of Maine4 aut
7001 a Rascovsky, Katyau University of Pennsylvania4 aut
7001 a Irwin, David J.u University of Pennsylvania4 aut
7001 a McMillan, Corey T.u University of Pennsylvania4 aut
7001 a Xie, Longu Hospital of the University of Pennsylvania,University of Pennsylvania4 aut
7001 a Wisse, Laura E.M.u Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Pennsylvania,Hospital of the University of Pennsylvania4 aut0 (Swepub:lu)la3343wi
7001 a Yushkevich, Paul A.u University of Pennsylvania,Hospital of the University of Pennsylvania4 aut
7001 a Kallogjeri, Dorinau Washington University in St. Louis4 aut
7001 a Grossman, Murrayu University of Pennsylvania4 aut
7001 a Cousins, Katheryn A.Q.u University of Pennsylvania4 aut
7102 a University of Connecticutb University of Pennsylvania4 org
7730 t Journal of Alzheimer's Diseaseg 89:2, s. 641-658q 89:2<641-658x 1387-2877
8564 u http://dx.doi.org/10.3233/JAD-215728y FULLTEXT
8564 8u https://lup.lub.lu.se/record/15827055-3461-44c7-a0ac-1a4f70e40f3e
8564 8u https://doi.org/10.3233/JAD-215728

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