Skiers with or without asthma have increased airway diffusion rate of NO from the airways : Konferensbidrag, Muntlig presentation med publicerat abstract (Refereegranskat)

• Exercise induced bronchoconstriction (EIB) is common in skiers and often treated with β2-agonists and inhaled corticosteroids (ICS). We examined 25 elite junior cross-country skiers (17 boys and 8 girls, age 18±1 y) pre and post a V̇O2max test to see how NO parameters of the lung changed. A health declaration was filled in and 6 boys and 2 girls declared that they had asthma diagnosed by a physician, whereas 5 of them were on ICS treatment. NO analysis was done with multiple flows (Högman-Meriläinen algorithm) before and within 10 min after the V̇O2max test. FENO50 was at rest 17 (11, 24) ppb (median, quartiles). CANO was 1.5 (1.1, 1.9) ppb, JawNO 0.75 (0.56, 1.55) nL/s, and CawNO 51 (26, 63) ppb. DawNO was 21 (17,25) mL/s, with only three skiers with values in the range of upper and lower quartiles for reference values. There were no differences in NO parameters between those declaring or not declaring asthma. After the V̇O2max test FENO50 decreased by 5 (3, 8) ppb (p<0.001), JawNO with 0.27 (0.15, 0.49) nL/s (p<0.001), CawNO with 6 (-14, 20) ppb (ns), DawNO with 4 (-3, 14) mL/s (p=0.032), while CANO increased by 0.6 (0.1, 1.2) ppb (p=0.006). Interestingly, the majority of participants had an increase in DawNO. An increase in DawNO has been found in allergic asthma together with elevated CawNO. The skiers did not have elevated CawNO, which indicate an absence of inflammation in the airway wall. Should they withhold ICS, since it does not affect DawNO? Modelling of lung NO production clearly shows that the EIB is distinct from allergic asthma.CANO=alveolar NO, JawNO=NO-flux from airways, CawNO=NO content in airway wall, DawNO=diffusion capacity over airway wall

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)