L773:1367 5931 OR L773:1879 0402
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Label free biochemical 2D and 3D imaging using secondary ion mass spectrometry.
- Fletcher, John, 1978 (author)
- Vickerman, John C (author)
- Winograd, Nicholas (author)
- Elsevier BV, 2011
- 2011
- English.
- In: Current opinion in chemical biology. - : Elsevier BV. - 1879-0402 .- 1367-5931. ; 15:5, s. 733-40
- Research review (peer-reviewed)
Abstract
Subject headings
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- Time-of-flight secondary ion mass spectrometry (ToF-SIMS) provides a method for the detection of native and exogenous compounds in biological samples on a cellular scale. Through the development of novel ion beams the amount of molecular signal available from the sample surface has been increased. Through the introduction of polyatomic ion beams, particularly C(60), ToF-SIMS can now be used to monitor molecular signals as a function of depth as the sample is eroded thus proving the ability to generate 3D molecular images. Here we describe how this new capability has led to the development of novel instrumentation for 3D molecular imaging while also highlighting the importance of sample preparation and discuss the challenges that still need to be overcome to maximise the impact of the technique.
Subject headings
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
Keyword
- Cell Membrane
- Spectrometry
- analysis
- Animals
- methods
- instrumentation
- Xenopus laevis
- Mass
- Software
- Humans
- analysis
- chemistry
- Phospholipids
- Three-Dimensional
- Ions
- methods
- instrumentation
- HeLa Cells
- Amino Acids
- instrumentation
- Molecular Imaging
- Secondary Ion
- Imaging
- Principal Component Analysis
- methods
- chemistry
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