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Antifungal activity of sustainable histone deacetylase inhibitors against planktonic cells and biofilms of Candida spp. and Cryptococcusneoformans

de Oliveira, Andressa Souza (författare)
Univ Brasilia, Fac Med, Trop Med Ctr, Lab Dev Therapeut Innovat, Campus Darcy Ribeiro, BR-70910900 Brasilia, DF, Brazil.;Univ Brasilia, Fac Hlth Sci, Postgrad Program Pharmaceut Sci, Asa Norte, Campus Darcy Ribeiro, BR-70910900 Brasilia, DF, Brazil.
de Oliveira, Jonathas Sales (författare)
Univ Fed Ceara, Specialized Med Mycol Ctr, Dept Pathol & Legal Med, Postgrad Program Med Microbiol, Rua Cel Nunes Melo 1315, BR-60430275 Fortaleza, CE, Brazil.
Kumar, Rajender (författare)
KTH,Glykovetenskap
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Silva, Fabiana Brandao Alves (författare)
Univ Brasilia, Fac Med, Postgrad Program Trop Med, Campus Darcy Ribeiro, BR-70910900 Brasilia, DF, Brazil.
Fernandes, Mirele Rodrigues (författare)
Univ Fed Ceara, Specialized Med Mycol Ctr, Dept Pathol & Legal Med, Postgrad Program Med Microbiol, Rua Cel Nunes Melo 1315, BR-60430275 Fortaleza, CE, Brazil.
Nobre, Feynman Dias (författare)
Univ Fed Ceara, Specialized Med Mycol Ctr, Dept Pathol & Legal Med, Postgrad Program Med Microbiol, Rua Cel Nunes Melo 1315, BR-60430275 Fortaleza, CE, Brazil.
Costa, Anderson da Cunha (författare)
Univ Fed Ceara, Specialized Med Mycol Ctr, Dept Pathol & Legal Med, Postgrad Program Med Microbiol, Rua Cel Nunes Melo 1315, BR-60430275 Fortaleza, CE, Brazil.
Albuquerque, Patricia (författare)
Univ Brasilia, Ctr Metropolitano Conjunto, Campus Ceilandia,Lote 01, BR-72220900 Brasilia, DF, Brazil.
Sidrim, Jose Julio Costa (författare)
Univ Fed Ceara, Specialized Med Mycol Ctr, Dept Pathol & Legal Med, Postgrad Program Med Microbiol, Rua Cel Nunes Melo 1315, BR-60430275 Fortaleza, CE, Brazil.
Rocha, Marcos Fabio Gadelha (författare)
Univ Fed Ceara, Specialized Med Mycol Ctr, Dept Pathol & Legal Med, Postgrad Program Med Microbiol, Rua Cel Nunes Melo 1315, BR-60430275 Fortaleza, CE, Brazil.
Santos, Flavia Almeida (författare)
Univ Fed Ceara, Dept Physiol & Pharmacol, Lab Nat Prod, Rua Cel Nunes Melo 1315, BR-60430275 Fortaleza, CE, Brazil.
Srivastava, Vaibhav (författare)
KTH,Glykovetenskap
Romeiro, Luiz Antonio Soares (författare)
Univ Brasilia, Fac Med, Trop Med Ctr, Lab Dev Therapeut Innovat, Campus Darcy Ribeiro, BR-70910900 Brasilia, DF, Brazil.;Univ Brasilia, Fac Hlth Sci, Postgrad Program Pharmaceut Sci, Asa Norte, Campus Darcy Ribeiro, BR-70910900 Brasilia, DF, Brazil.;Univ Brasilia, Fac Med, Postgrad Program Trop Med, Campus Darcy Ribeiro, BR-70910900 Brasilia, DF, Brazil.;Campus Univ Darcy Ribeiro, BR-70910900 Brasilia, DF, Brazil.
Brilhante, Raimunda Samia Nogueira (författare)
Univ Fed Ceara, Specialized Med Mycol Ctr, Dept Pathol & Legal Med, Postgrad Program Med Microbiol, Rua Cel Nunes Melo 1315, BR-60430275 Fortaleza, CE, Brazil.;Rua Coronel Nunes Melo 1315, BR-60420270 Fortaleza, CE, Brazil.
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Univ Brasilia, Fac Med, Trop Med Ctr, Lab Dev Therapeut Innovat, Campus Darcy Ribeiro, BR-70910900 Brasilia, DF, Brazil;Univ Brasilia, Fac Hlth Sci, Postgrad Program Pharmaceut Sci, Asa Norte, Campus Darcy Ribeiro, BR-70910900 Brasilia, DF, Brazil. Univ Fed Ceara, Specialized Med Mycol Ctr, Dept Pathol & Legal Med, Postgrad Program Med Microbiol, Rua Cel Nunes Melo 1315, BR-60430275 Fortaleza, CE, Brazil. (creator_code:org_t)
Oxford University Press (OUP), 2023
2023
Engelska.
Ingår i: Medical Mycology. - : Oxford University Press (OUP). - 1369-3786 .- 1460-2709. ; 61:8
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • The limited therapeutic options for fungal infections and the increased incidence of fungal strains resistant to antifungal drugs, especially Candida spp., require the development of new antifungal drugs and strategies. Histone deacetylase inhibitors (HDACi), like vorinostat, have been studied in cancer treatment and have antifungal effects, acting alone or synergistically with classical antifungals. Here we investigated the antifungal activity of two novel sustainable HDACi (LDT compounds) based on vorinostat structure. Molecular docking simulation studies reveal that LDT compounds can bind to Class-I HDACs of Candida albicans, C. tropicalis, and Cryptococcus neoformans, which showed similar binding mode to vorinostat. LDT compounds showed moderate activity when tested alone against fungi but act synergistically with antifungal azoles against Candida spp. They reduced biofilm formation by more than 50% in C. albicans (4 µg/mL), with the main action in fungal filamentation. Cytotoxicity of the LDT compounds against RAW264.7 cells was evaluated and LDT536 demonstrated cytotoxicity only at the concentration of 200 µmol/L, while LDT537 showed IC50 values of 29.12 µmol/L. Our data indicated that these sustainable and inexpensive HDACi have potential antifungal and antibiofilm activities, with better results than vorinostat, although further studies are necessary to better understand the mechanism against fungal cells.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

Nyckelord

antifungal activity
HDACi
hydroxamic acid
biofilm

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

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