Nineteen cases of persistent pruritic nodules and contact allergy to aluminium after injection of commonly used aluminium-adsorbed vaccines.

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Fältnamn	Indikatorer	Metadata
000		03606naa a2200313 4500
001		oai:gup.ub.gu.se/54501
003		SwePub
008		240528s2005 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/545012 URI
024	7	a https://doi.org/10.1007/s00431-005-1704-12 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Bergfors, Elisabet,d 1945u Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics4 aut0 (Swepub:gu)xberel
245	1 0	a Nineteen cases of persistent pruritic nodules and contact allergy to aluminium after injection of commonly used aluminium-adsorbed vaccines.
264		c 2005-07-26
264	1	b Springer Science and Business Media LLC,c 2005
520		a Rare cases of persistent pruritic nodules, sometimes associated with aluminium (Al) allergy, have been reported after the use of several Al adsorbed vaccines. During vaccine trials in the 1990s a high incidence of pruritic nodules (645 cases/76,000 recipients), in 77% associated with Al allergy, was observed after the administration of diphtheria-tetanus / acellular pertussis (DT/aP) vaccines from a single producer. In the present report 19 children with pruritic nodules after vaccination with Al hydroxide-adsorbed DTaP/polio+Hib (Infanrix, Pentavac) are described. The children had intensely itching nodules at the injection site, often aggravated during upper respiratory tract infections, and local skin alterations. So far, the symptoms have persisted for up to 7 years. The median time between vaccination and onset of symptoms was 1 month. 16 children were epicutaneously tested for Al, all with positive reactions indicating delayed hypersensitivity to Al. The condition is not commonly known but is important to recognise, as the child and the family may suffer considerably. Future vaccinations with Al-adsorbed vaccines may cause aggravation of the symptoms and the Al allergy. Al-containing skin products, such as antiperspirants, may cause contact dermatitis. Nodules may be mistaken for tumours. Even though the incidence of itching nodules and Al allergy after administration of Infanrix, Pentavac and other Al-adsorbed vaccines is probably low, research to replace Al adjuvants seems appropriate. We conclude that intensely itching subcutaneous nodules, lasting for many years, and hypersensitivity to aluminium may occur after DTaP/polio+Hib vaccination of infants.
653		a Adsorbed vaccines
653		a persistent itching nodules
653		a aluminium hypersensitivity
700	1	a Björkelund, Cecilia,d 1948u Gothenburg University,Göteborgs universitet,Institutionen för samhällsmedicin, Avdelningen för allmänmedicin,Institute of Community Medicine, Dept of Primary Health Care4 aut0 (Swepub:gu)xbjoce
700	1	a Trollfors, Birger,d 1947u Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics4 aut0 (Swepub:gu)xtrobi
710	2	a Göteborgs universitetb Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik4 org
773	0	t European journal of pediatricsd : Springer Science and Business Media LLCg 164:11, s. 691-7q 164:11<691-7x 0340-6199x 1432-1076
856	4 8	u https://gup.ub.gu.se/publication/54501
856	4 8	u https://doi.org/10.1007/s00431-005-1704-1

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