WFRF:(Andersen Lars L.)
Sökning: WFRF:(Andersen Lars L.) > (2020-2024) > Genome-wide associa...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 09500naa a2202065 4500 | |
| 001 | oai:DiVA.org:uu-505815 | |
| 003 | SwePub | |
| 008 | 230621s2023 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:6adcc06f-a8d0-4413-9604-f244c2628fdc | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5058152 URI |
| 024 | 7 | a https://doi.org/10.1038/s41588-023-01408-92 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/6adcc06f-a8d0-4413-9604-f244c2628fdc2 URI |
| 040 | a (SwePub)uud (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Williamson, Aliceu University of Cambridge4 aut |
| 245 | 1 0 | a Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake |
| 264 | 1 | b Springer Nature,c 2023 |
| 338 | a print2 rdacarrier | |
| 520 | a Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previous genetic studies have largely focused on insulin resistance in the fasting state, where hepatic insulin action dominates. Here we studied genetic variants influencing insulin levels measured 2 h after a glucose challenge in >55,000 participants from three ancestry groups. We identified ten new loci (P < 5 × 10-8) not previously associated with postchallenge insulin resistance, eight of which were shown to share their genetic architecture with type 2 diabetes in colocalization analyses. We investigated candidate genes at a subset of associated loci in cultured cells and identified nine candidate genes newly implicated in the expression or trafficking of GLUT4, the key glucose transporter in postprandial glucose uptake in muscle and fat. By focusing on postprandial insulin resistance, we highlighted the mechanisms of action at type 2 diabetes loci that are not adequately captured by studies of fasting glycemic traits. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 653 | a Blood Glucose | |
| 653 | a Diabetes Mellitus, Type 2 | |
| 653 | a Genome-Wide Association Study | |
| 653 | a Glucose | |
| 653 | a Humans | |
| 653 | a Insulin | |
| 653 | a Insulin Resistance | |
| 653 | a glucose | |
| 653 | a glucose transporter 4 | |
| 653 | a insulin | |
| 653 | a adipocyte | |
| 653 | a ancestry group | |
| 653 | a Article | |
| 653 | a body mass | |
| 653 | a cell culture | |
| 653 | a controlled study | |
| 653 | a gene expression | |
| 653 | a gene identification | |
| 653 | a genetic variability | |
| 653 | a genome-wide association study | |
| 653 | a glucose transport | |
| 653 | a human | |
| 653 | a insulin level | |
| 653 | a insulin resistance | |
| 653 | a meta analysis (topic) | |
| 653 | a non insulin dependent diabetes mellitus | |
| 653 | a transcription regulation | |
| 653 | a genetics | |
| 653 | a glucose blood level | |
| 653 | a metabolism | |
| 700 | 1 | a Norris, Dougall M4 aut |
| 700 | 1 | a Yin, Xianyong4 aut |
| 700 | 1 | a Broadaway, K Alaine4 aut |
| 700 | 1 | a Moxley, Anne H4 aut |
| 700 | 1 | a Vadlamudi, Swarooparani4 aut |
| 700 | 1 | a Wilson, Emma P4 aut |
| 700 | 1 | a Jackson, Anne U4 aut |
| 700 | 1 | a Ahuja, Vasudha4 aut |
| 700 | 1 | a Andersen, Mette K4 aut |
| 700 | 1 | a Arzumanyan, Zorayr4 aut |
| 700 | 1 | a Bonnycastle, Lori L4 aut |
| 700 | 1 | a Bornstein, Stefan R4 aut |
| 700 | 1 | a Bretschneider, Maxi P4 aut |
| 700 | 1 | a Buchanan, Thomas A4 aut |
| 700 | 1 | a Chang, Yi-Cheng4 aut |
| 700 | 1 | a Chuang, Lee-Ming4 aut |
| 700 | 1 | a Chung, Ren-Hua4 aut |
| 700 | 1 | a Clausen, Tine D4 aut |
| 700 | 1 | a Damm, Peter4 aut |
| 700 | 1 | a Delgado, Graciela E4 aut |
| 700 | 1 | a de Mello, Vanessa D4 aut |
| 700 | 1 | a Dupuis, Josée4 aut |
| 700 | 1 | a Dwivedi, Om P4 aut |
| 700 | 1 | a Erdos, Michael R4 aut |
| 700 | 1 | a Silva, Lilian Fernandes4 aut |
| 700 | 1 | a Frayling, Timothy M4 aut |
| 700 | 1 | a Gieger, Christian4 aut |
| 700 | 1 | a Goodarzi, Mark O4 aut |
| 700 | 1 | a Guo, Xiuqing4 aut |
| 700 | 1 | a Gustafsson, Stefanu Uppsala universitet,Klinisk epidemiologi4 aut0 (Swepub:uu)stegu732 |
| 700 | 1 | a Hakaste, Liisa4 aut |
| 700 | 1 | a Hammar, Ulfu Uppsala universitet,Molekylär epidemiologi4 aut0 (Swepub:uu)ulfha881 |
| 700 | 1 | a Hatem, G.u Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)ga5503ha |
| 700 | 1 | a Herrmann, Sandra4 aut |
| 700 | 1 | a Højlund, Kurt4 aut |
| 700 | 1 | a Horn, Katrin4 aut |
| 700 | 1 | a Hsueh, Willa A4 aut |
| 700 | 1 | a Hung, Yi-Jen4 aut |
| 700 | 1 | a Hwu, Chii-Min4 aut |
| 700 | 1 | a Jonsson, Anna4 aut |
| 700 | 1 | a Kårhus, Line L4 aut |
| 700 | 1 | a Kleber, Marcus E4 aut |
| 700 | 1 | a Kovacs, Peter4 aut |
| 700 | 1 | a Lakka, Timo A4 aut |
| 700 | 1 | a Lauzon, Marie4 aut |
| 700 | 1 | a Lee, I-Te4 aut |
| 700 | 1 | a Lindgren, Cecilia M4 aut |
| 700 | 1 | a Lindström, Jaana4 aut |
| 700 | 1 | a Linneberg, Allan4 aut |
| 700 | 1 | a Liu, Ching-Ti4 aut |
| 700 | 1 | a Luan, Jian'an4 aut |
| 700 | 1 | a Aly, D.M.u Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)di3053ma |
| 700 | 1 | a Mathiesen, Elisabeth4 aut |
| 700 | 1 | a Moissl, Angela P4 aut |
| 700 | 1 | a Morris, Andrew P4 aut |
| 700 | 1 | a Narisu, Narisu4 aut |
| 700 | 1 | a Perakakis, Nikolaos4 aut |
| 700 | 1 | a Peters, Annette4 aut |
| 700 | 1 | a Prasad, R.B.u Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,University of Helsinki4 aut0 (Swepub:lu)med-rpa |
| 700 | 1 | a Rodionov, Roman N4 aut |
| 700 | 1 | a Roll, Kathryn4 aut |
| 700 | 1 | a Rundsten, Carsten F4 aut |
| 700 | 1 | a Sarnowski, Chloé4 aut |
| 700 | 1 | a Savonen, Kai4 aut |
| 700 | 1 | a Scholz, Markus4 aut |
| 700 | 1 | a Sharma, Sapna4 aut |
| 700 | 1 | a Stinson, Sara E4 aut |
| 700 | 1 | a Suleman, Sufyan4 aut |
| 700 | 1 | a Tan, Jingyi4 aut |
| 700 | 1 | a Taylor, Kent D4 aut |
| 700 | 1 | a Uusitupa, Matti4 aut |
| 700 | 1 | a Vistisen, Dorte4 aut |
| 700 | 1 | a Witte, Daniel R4 aut |
| 700 | 1 | a Walther, Romy4 aut |
| 700 | 1 | a Wu, Peitao4 aut |
| 700 | 1 | a Xiang, Anny H4 aut |
| 700 | 1 | a Zethelius, Björnu Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)bjorzeth |
| 700 | 1 | a Ahlqvist, E.u Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)infl-eah |
| 700 | 1 | a Bergman, Richard N4 aut |
| 700 | 1 | a Chen, Yii-Der Ida4 aut |
| 700 | 1 | a Collins, Francis S4 aut |
| 700 | 1 | a Fall, Tove,d 1979-u Uppsala universitet,Molekylär epidemiologi4 aut0 (Swepub:uu)tovfa878 |
| 700 | 1 | a Florez, Jose C4 aut |
| 700 | 1 | a Fritsche, Andreas4 aut |
| 700 | 1 | a Grallert, Harald4 aut |
| 700 | 1 | a Groop, L.u Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,University of Helsinki4 aut0 (Swepub:lu)endo-lgr |
| 700 | 1 | a Hansen, Torben4 aut |
| 700 | 1 | a Koistinen, Heikki A4 aut |
| 700 | 1 | a Komulainen, Pirjo4 aut |
| 700 | 1 | a Laakso, Markku4 aut |
| 700 | 1 | a Lind, Larsu Uppsala universitet,Klinisk epidemiologi4 aut0 (Swepub:uu)larslind |
| 700 | 1 | a Loeffler, Markus4 aut |
| 700 | 1 | a März, Winfried4 aut |
| 700 | 1 | a Meigs, James Bu Lund University,University Hospital of Tubingen,Massachusetts General Hospital4 aut |
| 700 | 1 | a Raffel, Leslie J4 aut |
| 700 | 1 | a Rauramaa, Rainer4 aut |
| 700 | 1 | a Rotter, Jerome I4 aut |
| 700 | 1 | a Schwarz, Peter E H4 aut |
| 700 | 1 | a Stumvoll, Michael4 aut |
| 700 | 1 | a Sundström, Johan,c Professor,d 1971-u Uppsala universitet,Klinisk epidemiologi4 aut0 (Swepub:uu)johasund |
| 700 | 1 | a Tönjes, Anke4 aut |
| 700 | 1 | a Tuomi, Tiinamaija4 aut |
| 700 | 1 | a Tuomilehto, Jaakko4 aut |
| 700 | 1 | a Wagner, Robert4 aut |
| 700 | 1 | a Barroso, Inês4 aut |
| 700 | 1 | a Walker, Mark4 aut |
| 700 | 1 | a Grarup, Niels4 aut |
| 700 | 1 | a Boehnke, Michael4 aut |
| 700 | 1 | a Wareham, Nicholas J4 aut |
| 700 | 1 | a Mohlke, Karen L4 aut |
| 700 | 1 | a Wheeler, Eleanor4 aut |
| 700 | 1 | a O'Rahilly, Stephen4 aut |
| 700 | 1 | a Fazakerley, Daniel J4 aut |
| 700 | 1 | a Langenberg, Claudiau Queen Mary University,University of Cambridge,Berlin Institute of Health (BIH),Charité - University Medicine Berlin4 aut |
| 710 | 2 | a University of Cambridgeb Klinisk epidemiologi4 org |
| 710 | 2 | a et al. |
| 773 | 0 | t Nature Geneticsd : Springer Natureg 55:6, s. 973-983q 55:6<973-983x 1061-4036x 1546-1718 |
| 856 | 4 | u http://dx.doi.org/10.1038/s41588-023-01408-9y FULLTEXT |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-505815 |
| 856 | 4 8 | u https://doi.org/10.1038/s41588-023-01408-9 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/6adcc06f-a8d0-4413-9604-f244c2628fdc |
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- Sharma, Sapna
- Stinson, Sara E
- Suleman, Sufyan
- Tan, Jingyi
- Taylor, Kent D
- Uusitupa, Matti
- Vistisen, Dorte
- Witte, Daniel R
- Walther, Romy
- Wu, Peitao
- Xiang, Anny H
- Zethelius, Björn
- Ahlqvist, E.
- Bergman, Richard ...
- Chen, Yii-Der Id ...
- Collins, Francis ...
- Fall, Tove, 1979 ...
- Florez, Jose C
- Fritsche, Andrea ...
- Grallert, Harald
- Groop, L.
- Hansen, Torben
- Koistinen, Heikk ...
- Komulainen, Pirj ...
- Laakso, Markku
- Lind, Lars
- Loeffler, Markus
- März, Winfried
- Meigs, James B
- Raffel, Leslie J
- Rauramaa, Rainer
- Rotter, Jerome I
- Schwarz, Peter E ...
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- Sundström, Johan ...
- Tönjes, Anke
- Tuomi, Tiinamaij ...
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- Walker, Mark
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