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Association between...
Association between ecg abnormalities and fatal cardiovascular disease among patients with and without severe mental illness
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- Polcwiartek, Christoffer (författare)
- Duke University Medical Center,Aalborg University Hospital,Aalborg University
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- Atwater, Brett D. (författare)
- Duke University Medical Center
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- Kragholm, Kristian (författare)
- Aalborg University Hospital
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- Friedman, Daniel J. (författare)
- Yale University
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- Barcella, Carlo A. (författare)
- Gentofte Hospital
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- Attar, Rubina (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Aalborg University Hospital
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- Graff, Claus (författare)
- Aalborg University
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- Nielsen, Jonas B. (författare)
- Copenhagen University Hospital
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- Pietersen, Adrian (författare)
- Copenhagen General Practitioners Laborator
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- Søgaard, Peter (författare)
- Aalborg University,Aalborg University Hospital
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- Torp-Pedersen, Christian (författare)
- Aalborg University Hospital,Hillerod Hospital
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- Jensen, Svend E. (författare)
- Aalborg University Hospital,Aalborg University
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(creator_code:org_t)
- 2021
- 2021
- Engelska 11 s.
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Ingår i: Journal of the American Heart Association. - 2047-9980. ; 10:2, s. 1-11
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: ECG abnormalities are associated with adverse outcomes in the general population, but their prognostic significance in severe mental illness (SMI) remains unexplored. We investigated associations between no, minor, and major ECG abnormalities and fatal cardiovascular disease (CVD) among patients with SMI compared with controls without mental illness. METHODS AND RESULTS: We cross-linked data from Danish nationwide registries and included primary care patients with digital ECGs from 2001 to 2015. Patients had SMI if they were diagnosed with schizophrenia, bipolar disorder, or severe depression before ECG recording. Controls were required to be without any prior mental illness or psychotropic medication use. Fatal CVD was assessed using hazard ratios (HRs) with 95% CIs and standardized 10-year absolute risks. Of 346 552 patients, 10 028 had SMI (3%; median age, 54 years; male, 45%), and 336 524 were controls (97%; median age, 56 years; male, 48%). We observed an interaction between SMI and ECG abnormalities on fatal CVD (P<0.001). Severe mental illness was associated with fatal CVD across no (HR, 2.17; 95% CI, 1.95–2.43), minor (HR, 1.90; 95% CI, 1.49–2.42), and major (HR, 1.40; 95% CI, 1.26–1.55) ECG abnormalities compared with controls. Across age-and sex-specific subgroups, SMI patients with ECG abnormalities but no CVD at baseline had highest standardized 10-year absolute risks of fatal CVD. CONCLUSIONS: ECG abnormalities conferred a poorer prognosis among patients with SMI compared with controls without mental illness. SMI patients with ECG abnormalities but no CVD represent a high-risk population that may benefit from greater surveillance and risk management.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- ECG
- Primary care
- Risk prediction
- Severe mental illness
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- ref (ämneskategori)
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Polcwiartek, Chr ...
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Atwater, Brett D ...
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Kragholm, Kristi ...
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Friedman, Daniel ...
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Barcella, Carlo ...
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Attar, Rubina
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visa fler...
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Graff, Claus
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Nielsen, Jonas B ...
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Pietersen, Adria ...
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Søgaard, Peter
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Torp-Pedersen, C ...
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Jensen, Svend E.
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