SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Bonde Jens Peter E.)
 

Sökning: WFRF:(Bonde Jens Peter E.) > Exposure to Perfluo...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004819naa a2200589 4500
001oai:lup.lub.lu.se:c25ca643-a239-4e14-af4e-4444c20e3b64
003SwePub
008160401s2014 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/48820062 URI
0247 a https://doi.org/10.1002/em.218742 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Leter, Giorgio4 aut
2451 0a Exposure to Perfluoroalkyl Substances and Sperm DNA Global Methylation in Arctic and European Populations
264 c 2014-06-03
264 1b Wiley,c 2014
520 a Perfluoroalkyl substances (PFASs) are widely used in a variety of industrial processes and products, and have been detected globally in humans and wildlife. PFASs are suspected to interfere with endocrine signaling and to adversely affect human reproductive health. The aim of the present study was to investigate the associations between exposure to PFASs and sperm global methylation levels in a population of non-occupationally exposed fertile men. Measurements of PFASs in serum from 262 partners of pregnant women from Greenland, Poland and Ukraine, were also carried out by liquid chromatography tandem mass spectrometry. Perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA) were detected in 97% of the blood samples. Two surrogate markers were used to assess DNA global methylation levels in semen samples from the same men: (a) average DNA methylation level in repetitive DNA sequences (Alu, LINE-1, Sat alpha) quantified by PCR-pyrosequencing after bisulfite conversion; (b) flow cytometric immunodetection of 5-methyl-cytosines. After multivariate linear regression analysis, no major consistent associations between PFASs exposure and sperm DNA global methylation endpoints could be detected. However, since weak but statistically significant associations of different PFASs with DNA hypo- and hypermethylation were found in some of the studied populations, effects of PFASs on sperm epigenetic processes cannot be completely excluded, and this issue warrants further investigation. (C) 2014 Wiley Periodicals, Inc.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
653 a perfluoroalkyl substances
653 a human spermatozoa
653 a DNA methylation
653 a pyrosequencing
653 a flow cytometry
653 a epidemiology
7001 a Consales, Claudia4 aut
7001 a Eleuteri, Patrizia4 aut
7001 a Uccelli, Raffaella4 aut
7001 a Specht, Ina O.4 aut
7001 a Toft, Gunnar4 aut
7001 a Moccia, Tania4 aut
7001 a Budillon, Alfredo4 aut
7001 a Jönsson, Bo Au Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)ymed-bjo
7001 a Lindh, Christianu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)ymed-cli
7001 a Giwercman, Aleksanderu Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)kir-agi
7001 a Pedersen, Henning S.4 aut
7001 a Ludwicki, Jan K.4 aut
7001 a Zviezdai, Valentyna4 aut
7001 a Heederik, Dick4 aut
7001 a Bonde, Jens Peter E.4 aut
7001 a Spano, Marcello4 aut
7102 a Avdelningen för arbets- och miljömedicinb Institutionen för laboratoriemedicin4 org
7730 t Environmental and Molecular Mutagenesisd : Wileyg 55:7, s. 591-600q 55:7<591-600x 1098-2280x 0893-6692
8564 u http://dx.doi.org/10.1002/em.21874y FULLTEXT
8564 u http://dspace.library.uu.nl/bitstream/1874/305607/1/em21874.pdf
8564 8u https://lup.lub.lu.se/record/4882006
8564 8u https://doi.org/10.1002/em.21874

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy