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  • Haigh, Daisy B.Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom; School of Veterinary Medicine and Sciences, University of Nottingham, Sutton Bonington, United Kingdom,Univ Nottingham, Biodiscovery Inst, Univ Pk, Nottingham NG7 2rd, England.;Univ Nottingham, Sch Vet Med & Sci, Loughborough LE12 5RD, England. (författare)

The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-10-20
  • MDPI,2022
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-200824
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-200824URI
  • https://doi.org/10.3390/cancers14205148DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-56077URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Prostate cancer (PCa) is a leading cause of cancer-related deaths and is driven by aberrant androgen receptor (AR) signalling. For this reason, androgen deprivation therapies (ADTs) that suppress androgen-induced PCa progression either by preventing androgen biosynthesis or via AR signalling inhibition (ARSi) are common treatments. The N6-methyladenosine (m6A) RNA modification is involved in regulating mRNA expression, translation, and alternative splicing, and through these mechanisms has been implicated in cancer development and progression. RNA-m6A is dynamically regulated by the METTL3 RNA methyltransferase complex and the FTO and ALKBH5 demethylases. While there is evidence supporting a role for aberrant METTL3 in many cancer types, including localised PCa, the wider contribution of METTL3, and by inference m6A, in androgen signalling in PCa remains poorly understood. Therefore, the aim of this study was to investigate the expression of METTL3 in PCa patients and study the clinical and functional relevance of METTL3 in PCa. It was found that METTL3 is aberrantly expressed in PCa patient samples and that siRNA-mediated METTL3 knockdown or METTL3-pharmacological inhibition significantly alters the basal and androgen-regulated transcriptome in PCa, which supports targeting m6A as a novel approach to modulate androgen signalling in PCa.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Woodcock, Corinne L.Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom; School of Veterinary Medicine and Sciences, University of Nottingham, Sutton Bonington, United Kingdom,Univ Nottingham, Biodiscovery Inst, Univ Pk, Nottingham NG7 2rd, England.;Univ Nottingham, Sch Vet Med & Sci, Loughborough LE12 5RD, England. (författare)
  • Lothion-Roy, JenniferBiodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom; School of Veterinary Medicine and Sciences, University of Nottingham, Sutton Bonington, United Kingdom,Univ Nottingham, Biodiscovery Inst, Univ Pk, Nottingham NG7 2rd, England.;Univ Nottingham, Sch Vet Med & Sci, Loughborough LE12 5RD, England. (författare)
  • Harris, Anna E.Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom; School of Veterinary Medicine and Sciences, University of Nottingham, Sutton Bonington, United Kingdom,Univ Nottingham, Biodiscovery Inst, Univ Pk, Nottingham NG7 2rd, England.;Univ Nottingham, Sch Vet Med & Sci, Loughborough LE12 5RD, England. (författare)
  • Metzler, Veronika M.Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom; School of Veterinary Medicine and Sciences, University of Nottingham, Sutton Bonington, United Kingdom,Univ Nottingham, Biodiscovery Inst, Univ Pk, Nottingham NG7 2rd, England.;Univ Nottingham, Sch Vet Med & Sci, Loughborough LE12 5RD, England. (författare)
  • Persson, Jenny L.,ProfessorMalmö universitet,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Biomedical Sciences, Malmö Universitet, Malmö, Sweden,Institutionen för biomedicinsk vetenskap (BMV),Umea Univ, Dept Mol Biol, S-90187 Umea, Sweden.(Swepub:mau)ak8037 (författare)
  • Robinson, Brian D.Department of Pathology, Weill Cornell Medicine, NY, New York, United States,Weill Cornell Med, Dept Pathol, New York, NY 10065 USA. (författare)
  • Khani, FrancescaDepartment of Pathology, Weill Cornell Medicine, NY, New York, United States,Weill Cornell Med, Dept Pathol, New York, NY 10065 USA. (författare)
  • Alsaleem, MansourBiodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom; School of Medicine, University of Nottingham, Nottingham, United Kingdom; Department of Applied Medical Science, Applied College, Qassim University, Qassim, Unayzah, Saudi Arabia,Univ Nottingham, Biodiscovery Inst, Univ Pk, Nottingham NG7 2rd, England.;Univ Nottingham, Sch Med, Nottingham NG7 2RD, England.;Qassim Univ, Appl Coll, Dept Appl Med Sci, Unayzah 51911, Saudi Arabia. (författare)
  • Ntekim, AtaraSchool of Veterinary Medicine and Sciences, University of Nottingham, Sutton Bonington, United Kingdom; Department of Radiation Oncology, University College Hospital, University of Ibadan, Ibadan, Nigeria,Univ Nottingham, Sch Vet Med & Sci, Loughborough LE12 5RD, England.;Univ Ibadan, Univ Coll Hosp, Dept Radiat Oncol, Ibadan 200132, Nigeria. (författare)
  • Madhusudan, SrinivasanBiodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom; School of Medicine, University of Nottingham, Nottingham, United Kingdom,Univ Nottingham, Biodiscovery Inst, Univ Pk, Nottingham NG7 2rd, England.;Univ Nottingham, Sch Med, Nottingham NG7 2RD, England. (författare)
  • Davis, Melissa B.Department of Surgery, Weill Cornell Medicine, NY, New York, United States,Weill Cornell Med, Dept Surg, New York, NY 10065 USA. (författare)
  • Laursen, Kristian B.Department of Pharmacology, Weill Cornell Medicine, NY, New York, United States,Weill Cornell Med, Dept Pharmacol, New York, NY 10065 USA. (författare)
  • Gudas, Lorraine J.Department of Pharmacology, Weill Cornell Medicine, NY, New York, United States,Weill Cornell Med, Dept Pharmacol, New York, NY 10065 USA. (författare)
  • Rutland, Catrin S.School of Veterinary Medicine and Sciences, University of Nottingham, Sutton Bonington, United Kingdom,Univ Nottingham, Sch Vet Med & Sci, Loughborough LE12 5RD, England. (författare)
  • Toss, Michael S.Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom; School of Medicine, University of Nottingham, Nottingham, United Kingdom,Univ Nottingham, Biodiscovery Inst, Univ Pk, Nottingham NG7 2rd, England.;Univ Nottingham, Sch Med, Nottingham NG7 2RD, England. (författare)
  • Archer, NathanSchool of Veterinary Medicine and Sciences, University of Nottingham, Sutton Bonington, United Kingdom,Univ Nottingham, Sch Vet Med & Sci, Loughborough LE12 5RD, England. (författare)
  • Bodi, ZsuzsannaSchool of Biosciences, University of Nottingham, Sutton Bonington, United Kingdom,Univ Nottingham, Sch Biosci, Loughborough LE12 5RD, England. (författare)
  • Rakha, Emad A.School of Medicine, University of Nottingham, Nottingham, United Kingdom,Univ Nottingham, Sch Med, Nottingham NG7 2RD, England. (författare)
  • Fray, Rupert G.School of Biosciences, University of Nottingham, Sutton Bonington, United Kingdom,Univ Nottingham, Sch Biosci, Loughborough LE12 5RD, England. (författare)
  • Jeyapalan, Jennie N.Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom; School of Veterinary Medicine and Sciences, University of Nottingham, Sutton Bonington, United Kingdom,Univ Nottingham, Biodiscovery Inst, Univ Pk, Nottingham NG7 2rd, England.;Univ Nottingham, Sch Vet Med & Sci, Loughborough LE12 5RD, England. (författare)
  • Mongan, Nigel P.Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom; School of Veterinary Medicine and Sciences, University of Nottingham, Sutton Bonington, United Kingdom; Department of Pharmacology, Weill Cornell Medicine, NY, New York, United States,Univ Nottingham, Biodiscovery Inst, Univ Pk, Nottingham NG7 2rd, England.;Univ Nottingham, Sch Vet Med & Sci, Loughborough LE12 5RD, England.;Weill Cornell Med, Dept Pharmacol, New York, NY 10065 USA. (författare)
  • Biodiscovery Institute, University of Nottingham, University Park, Nottingham, United Kingdom; School of Veterinary Medicine and Sciences, University of Nottingham, Sutton Bonington, United KingdomUniv Nottingham, Biodiscovery Inst, Univ Pk, Nottingham NG7 2rd, England.;Univ Nottingham, Sch Vet Med & Sci, Loughborough LE12 5RD, England. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cancers: MDPI14:202072-6694

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  • Cancers (Sök värdpublikationen i LIBRIS)

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