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The 2021 Updated Eu...
The 2021 Updated European Association of Urology Guidelines on Renal Cell Carcinoma : Immune Checkpoint Inhibitor–based Combination Therapies for Treatment-naive Metastatic Clear-cell Renal Cell Carcinoma Are Standard of Care
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- Bedke, Jens (författare)
- Department of Urology, University Hospital Tübingen, Tuebingen, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Albiges, Laurence (författare)
- Department of Cancer Medicine, Gustave Roussy, Université Paris-Saclay, Villejuif, France,Institut Gustave Roussy
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- Capitanio, Umberto (författare)
- Department of Urology, San Raffaele Scientific Institute, Milan, Italy; Division of Experimental Oncology/Unit of Urology, URI, IRCCS San Raffaele Hospital, Milan, Italy
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- Giles, Rachel H. (författare)
- International Kidney Cancer Coalition (IKCC), Duivendrecht, Netherlands
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- Hora, Milan (författare)
- Department of Urology, University Hospital Pilsen and Faculty of Medicine in Pilsen, Charles University, Czech Republic
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- Lam, Thomas B. (författare)
- Academic Urology Unit, University of Aberdeen, Aberdeen, United Kingdom; Department of Urology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom
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- Ljungberg, Börje, Professor, 1949- (författare)
- Umeå University,Umeå universitet,Urologi och andrologi
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- Marconi, Lorenzo (författare)
- Department of Urology, Coimbra University Hospital, Coimbra, Portugal
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- Klatte, Tobias (författare)
- Department of Urology, Royal Bournemouth Hospital, Bournemouth, United Kingdom; Department of Surgery, University of Cambridge, Cambridge, United Kingdom
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- Volpe, Alessandro (författare)
- Department of Urology, University of Eastern Piedmont, Maggiore della Carità Hospital, Novara, Italy
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- Abu-Ghanem, Yasmin (författare)
- Department of Urology, Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel
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- Dabestani, Saeed (författare)
- Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups
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- Fernández Pello, Sergio (författare)
- Department of Urology, Cabueñes University Hospital, Gijón, Spain
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- Hofmann, Fabian (författare)
- Umeå University,Umeå universitet,Urologi och andrologi,Sunderby Sjukhus, Luleå, Sweden
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- Kuusk, Teele (författare)
- Department of Urology, Darent Valley Hospital, Dartford and Gravesham NHS Trust, Dartford, United Kingdom
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- Tahbaz, Rana (författare)
- Department of Urology, Charité University Hospital Berlin, Germany,Charité - University Medicine Berlin
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- Powles, Thomas (författare)
- The Royal Free NHS Trust and Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
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- Bex, Axel (författare)
- The Royal Free London NHS Foundation Trust, London, United Kingdom; UCL Division of Surgery and Interventional Science, London, United Kingdom; Department of Urology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: European Urology. - : Elsevier. - 0302-2838 .- 1873-7560. ; 80:4, s. 393-397
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- The recent randomized controlled phase III CLEAR trial results are the last to complement immune checkpoint inhibitor (ICI)-based doublet combination therapies for treatment-naïve metastatic clear-cell renal cell carcinoma. The CLEAR trial demonstrated an improved progression-free survival (PFS), overall survival (OS), and an objective response rate (ORR) benefit for the combination of lenvatinib plus pembrolizumab over sunitinib. The CheckMate-9ER trial update demonstrated an ongoing PFS, OS, and quality-of-life benefit for cabozantinib plus nivolumab over sunitinib as did the update of Keynote-426 for axitinib plus pembrolizumab in the intention-to-treat population, with a PFS benefit seen across all International Metastatic Database Consortium (IMDC) subgroups. In the IMDC intermediate- and poor-risk groups, the CheckMate-214 trial of ipilimumab plus nivolumab confirmed the OS benefit with a PFS plateauing after 30 months. The RCC Guidelines Panel recommends three tyrosine kinase inhibitors + ICI combinations of axitinib plus pembrolizumab, cabozantinib plus nivolumab, and lenvatinib plus pembrolizumab across all IMDC risk groups in advanced first-line RCC, and dual immunotherapy of ipilimumab and nivolumab in IMDC intermediate- and poor-risk groups. Patient summary: New data from combination trials with immune checkpoint inhibitors for advanced kidney cancer confirm a survival benefit for lenvatinib plus pembrolizumab, cabozantinib plus nivolumab (with improved quality-of-life), axitinib plus pembrolizumab, and ipilimumab plus nivolumab. These combination therapies are recommended as first-line treatment for advanced kidney cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Cabozantinib
- Clear-cell
- First-line
- Lenvatinib
- pembrolzumab
- nivolumab
- Renal cell carcinoma
- Systemic therapy
- Treatment-naive
- Cabozantinib
- Clear-cell
- First-line
- Lenvatinib, pembrolzumab, nivolumab
- Renal cell carcinoma
- Systemic therapy
- Treatment-naive
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Bedke, Jens
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Albiges, Laurenc ...
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Capitanio, Umber ...
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Giles, Rachel H.
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Hora, Milan
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Lam, Thomas B.
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Ljungberg, Börje ...
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Marconi, Lorenzo
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Klatte, Tobias
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Volpe, Alessandr ...
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Abu-Ghanem, Yasm ...
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Dabestani, Saeed
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Fernández Pello, ...
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Hofmann, Fabian
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Kuusk, Teele
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Tahbaz, Rana
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Powles, Thomas
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Bex, Axel
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