Sökning: WFRF:(Ferrand Drake Del Castillo Gustav 1990) >
Electrically Switch...
Electrically Switchable Polymer Brushes for Protein Capture and Release in Biological Environments**
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- Ferrand-Drake Del Castillo, Gustav, 1990 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Kyriakidou, Maria (författare)
- Cardiff University
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Adali, Zeynep (författare)
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- Xiong, Kunli, 1987 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Hailes, Rebekah, 1992 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Dahlin, Andreas, 1980 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2022-03-30
- 2022
- Engelska.
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Ingår i: Angewandte Chemie - International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 61:22
- Relaterad länk:
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https://research.cha... (primary) (free)
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- Interfaces functionalized with polymers are known for providing excellent resistance towards biomolecular adsorption and for their ability to bind high amounts of protein while preserving their structure. However, making an interface that switches between these two states has proven challenging and concepts to date rely on changes in the physiochemical environment, which is static in biological systems. Here we present the first interface that can be electrically switched between a high-capacity (>1 μg cm−2) multilayer protein binding state and a completely non-fouling state (no detectable adsorption). Switching is possible over multiple cycles without any regeneration. Importantly, switching works even when the interface is in direct contact with biological fluids and a buffered environment. The technology offers many applications such as zero fouling on demand, patterning or separation of proteins as well as controlled release of biologics in a physiological environment, showing high potential for future drug delivery in vivo.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
Nyckelord
- Electrochemistry
- Polymer Brushes
- Proteins
- Adsorption
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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