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Protective Effect o...
Protective Effect of Pregnancy in Rural South Africa : Questioning the Concept of "Indirect Cause'' of Maternal Death
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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2013-05-13
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PLOS, Public Library of Science,2013
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-76269
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-76269URI
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https://doi.org/10.1371/journal.pone.0064414DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Measurement of the level and composition of maternal mortality depends on the definition used, with inconsistencies leading to inflated rates and invalid comparisons across settings. This study investigates the differences in risk of death for women in their reproductive years during and outside the maternal risk period (pregnancy, delivery, puerperium), focusing on specific causes of infectious, non-communicable and external causes of death after separating out direct obstetrical causes. Methods: Data on all deaths of women aged 15-49 years that occurred in the Agincourt sub-district between 1992 and 2010 were obtained from the Agincourt health and socio-demographic surveillance system (HDSS) located in rural South Africa. Causes of death were assessed using a validated verbal autopsy instrument. Analysis included 2170 deaths, of which 137 occurred during the maternal risk period. Findings: Overall, women had significantly lower mortality during the maternal risk period than outside it (age-standardized RR = 0.75; 95% CI = 0.63-0.89). This was true in most age groups with the exception of adolescents aged 15-19 years where the risk of death was higher. Mortality from most causes, other than obstetric causes, was lower during the maternal risk period except for malaria, cardiovascular diseases and violence where there were no differences. Lower mortality was significant for HIV/AIDS (RR = 0.29, P<0.0001), cancers (RR = 0.10, P<0.023), and accidents (RR = 0, P<0.0001). Interpretation: In this rural setting typical of much of Southern Africa, pregnancy was largely protective against the risk of death, most likely because of a strong selection effect amongst those women who conceived successfully. The concept of indirect cause of maternal death needs to be re-examined.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Kahn, KathleenUmeå universitet,Epidemiologi och global hälsa(Swepub:umu)kaka0045
(author)
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Collinson, MarkUmeå universitet,Epidemiologi och global hälsa(Swepub:umu)maco0022
(author)
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Gomez-Olive, Xavier
(author)
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Tollman, Stephen
(author)
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Umeå universitetEpidemiologi och global hälsa
(creator_code:org_t)
Related titles
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In:PLOS ONE: PLOS, Public Library of Science8:5, s. e64414-1932-6203
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