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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004737naa a2200637 4500
001oai:lup.lub.lu.se:446a3349-5fb8-4cfd-beb3-de7786302b82
003SwePub
008160401s2014 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/49079232 URI
0247 a https://doi.org/10.1371/journal.pgen.10048542 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Tönjes, Anke4 aut
2451 0a Genome Wide Meta-analysis Highlights the Role of Genetic Variation in RARRES2 in the Regulation of Circulating Serum Chemerin.
264 c 2014-12-18
264 1b Public Library of Science (PLoS),c 2014
338 a electronic2 rdacarrier
520 a Chemerin is an adipokine proposed to link obesity and chronic inflammation of adipose tissue. Genetic factors determining chemerin release from adipose tissue are yet unknown. We conducted a meta-analysis of genome-wide association studies (GWAS) for serum chemerin in three independent cohorts from Europe: Sorbs and KORA from Germany and PPP-Botnia from Finland (total N = 2,791). In addition, we measured mRNA expression of genes within the associated loci in peripheral mononuclear cells by micro-arrays, and within adipose tissue by quantitative RT-PCR and performed mRNA expression quantitative trait and expression-chemerin association studies to functionally substantiate our loci. Heritability estimate of circulating chemerin levels was 16.2% in the Sorbs cohort. Thirty single nucleotide polymorphisms (SNPs) at chromosome 7 within the retinoic acid receptor responder 2 (RARRES2)/Leucine Rich Repeat Containing (LRRC61) locus reached genome-wide significance (p<5.0×10-8) in the meta-analysis (the strongest evidence for association at rs7806429 with p = 7.8×10-14, beta = -0.067, explained variance 2.0%). All other SNPs within the cluster were in linkage disequilibrium with rs7806429 (minimum r2 = 0.43 in the Sorbs cohort). The results of the subgroup analyses of males and females were consistent with the results found in the total cohort. No significant SNP-sex interaction was observed. rs7806429 was associated with mRNA expression of RARRES2 in visceral adipose tissue in women (p<0.05 after adjusting for age and body mass index). In conclusion, the present meta-GWAS combined with mRNA expression studies highlights the role of genetic variation in the RARRES2 locus in the regulation of circulating chemerin concentrations.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Scholz, Markus4 aut
7001 a Breitfeld, Jana4 aut
7001 a Marzi, Carola4 aut
7001 a Grallert, Harald4 aut
7001 a Gross, Arnd4 aut
7001 a Ladenvall, Claes4 aut
7001 a Schleinitz, Dorit4 aut
7001 a Krause, Kerstin4 aut
7001 a Kirsten, Holger4 aut
7001 a Laurila, Esau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-ela
7001 a Kriebel, Jennifer4 aut
7001 a Thorand, Barbara4 aut
7001 a Rathmann, Wolfgang4 aut
7001 a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr
7001 a Prokopenko, Inga4 aut
7001 a Isomaa, Bo4 aut
7001 a Beutner, Frank4 aut
7001 a Kratzsch, Jürgen4 aut
7001 a Thiery, Joachim4 aut
7001 a Fasshauer, Mathias4 aut
7001 a Klöting, Nora4 aut
7001 a Gieger, Christian4 aut
7001 a Blüher, Matthias4 aut
7001 a Stumvoll, Michael4 aut
7001 a Kovacs, Peter4 aut
7102 a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org
7730 t PLoS Geneticsd : Public Library of Science (PLoS)g 10:12q 10:12x 1553-7404
8564 u https://portal.research.lu.se/files/2385121/7851915x primaryx freey FULLTEXT
8564 u http://www.ncbi.nlm.nih.gov/pubmed/25521368?dopt=Abstracty FULLTEXT
8564 u http://dx.doi.org/10.1371/journal.pgen.1004854x freey FULLTEXT
8564 u https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1004854&type=printable
8564 8u https://lup.lub.lu.se/record/4907923
8564 8u https://doi.org/10.1371/journal.pgen.1004854

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