Fetal exposure to paternal smoking and semen quality in the adult son

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Fetal exposure to paternal smoking and semen quality in the adult son

Hærvig, Katia Keglberg (författare): University of Copenhagen,Frederiksberg Hospital

Høyer, Birgit Bjerre (författare): Frederiksberg Hospital,Aarhus University

Giwercman, Aleksander (författare): Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups

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Hougaard, Karin Sørig (författare): University of Copenhagen,The National Research Centre for the Working Environment

Ramlau-Hansen, Cecilia Høst (författare): Aarhus University

Specht, Ina Olmer (författare): Frederiksberg Hospital

Toft, Gunnar (författare): Aarhus University Hospital

Bonde, Jens Peter (författare): Frederiksberg Hospital,University of Copenhagen

Søgaard Tøttenborg, Sandra (författare): Frederiksberg Hospital

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(creator_code:org_t)

2020-03-24
2020
Engelska 9 s.
Ingår i: Andrology. - : Wiley. - 2047-2919 .- 2047-2927. ; 8:5, s. 1117-1125

Relaterad länk:: http://dx.doi.org/10...; visa fler...; https://lup.lub.lu.s...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Background: The negative impact of maternal smoking during pregnancy on offspring semen quality is well established. Less is known about the impact of paternal smoking. Methods: We estimated differences in semen parameters and testicle size according to paternal smoking in 772 adult sons of women enrolled in the Danish National Birth Cohort when pregnant. Parents’ smoking was reported around gestational week 16, and analyses were adjusted for parents’ ages at conception, maternal pre-pregnancy body mass index, maternal alcohol and caffeine intake, family occupational status, ejaculatory abstinence time, clinic of semen analysis, and season. Results: Sons of smoking fathers and non-smoking mothers had a 10% (95% confidence interval: −24%, 7%) lower semen concentration and 11% (95% confidence interval: −27%, 8%) lower sperm count than sons of non-smoking parents. Having two smoking parents was associated with 19% reduction in sperm count (95% confidence interval: −37%, 3%). Paternal smoking was not associated with volume, motility, or morphology. Adjusting for maternal smoking, paternal smoking was associated with a 26% increased risk of small testicular volume (95% confidence interval: 0.89, 1.78). Discussion: Exclusion of sons with a history of testicular cancer, chemotherapy, orchiectomy, and with only one or no testicles may have caused us to underestimate associations if these men's reproductive health including semen quality are in fact more sensitive to paternal smoking. Conclusion: The study provides limited support for slightly lower sperm concentration and total sperm concentration in sons of smoking fathers, but findings are also compatible with no association.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)

Nyckelord

fetal programming
infertility
paternal exposure
sperm count

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Av författaren/redakt...: Hærvig, Katia Ke ...; Høyer, Birgit Bj ...; Giwercman, Aleks ...; Hougaard, Karin ...; Ramlau-Hansen, C ...; Specht, Ina Olme ...; visa fler...; Toft, Gunnar; Bonde, Jens Pete ...; Søgaard Tøttenbo ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Folkhälsovetensk ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Reproduktionsmed ...

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Av lärosätet: Lunds universitet

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