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FältnamnIndikatorerMetadata
00040609naa a2201765 4500
001oai:DiVA.org:ltu-82754
003SwePub
008210202s2020 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-429065
024a https://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-827542 URI
024a https://doi.org/10.2337/db20-00702 DOI
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4290652 URI
040 a (SwePub)ltud (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Yaghootkar, Haniehu Luleå tekniska universitet,Medicinsk vetenskap,Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, U.K.; Research Centre for Optimal Health, School of Life Sciences, University of Westminster, London, U.K.,Univ Exeter, Royal Devon & Exeter Hosp, Genet Complex Traits, Med Sch, Exeter, Devon, England.;Luleå Univ Technol, Div Med Sci, Dept Hlth Sci, Luleå, Sweden.;Univ Westminster, Sch Life Sci, Res Ctr Optimal Hlth, London, England.4 aut0 (Swepub:ltu)hanyag
2451 0a Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity
264 c 2020-09-11
264 1b American Diabetes Association,c 2020
338 a print2 rdacarrier
500 a Godkänd;2021;Nivå 0;2021-02-02 (alebob);Finansiär: Data Tecnica International, United States Department of Health & Human Services (F31HG009850), National Institutes of Health, National Institute on Aging, Johnson & Johnson USA, National Human Genome Research Institute 
520 a Leptin influences food intake by informing the brain about the status of body fat stores. Rare LEP mutations associated with congenital leptin deficiency cause severe early-onset obesity that can be mitigated by administering leptin. However, the role of genetic regulation of leptin in polygenic obesity remains poorly understood. We performed an exome-based analysis in up to 57,232 individuals of diverse ancestries to identify genetic variants that influence adiposity-adjusted leptin concentrations. We identify five novel variants, including four missense variants, in LEP, ZNF800, KLHL31, and ACTL9, and one intergenic variant near KLF14. The missense variant Val94Met (rs17151919) in LEP was common in individuals of African ancestry only, and its association with lower leptin concentrations was specific to this ancestry (P = 2 × 10-16, n = 3,901). Using in vitro analyses, we show that the Met94 allele decreases leptin secretion. We also show that the Met94 allele is associated with higher BMI in young African-ancestry children but not in adults, suggesting that leptin regulates early adiposity.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
700a Zhang, Yiyingu Division of Molecular Genetics, Department of PediatriQuantinuum Research LLC, San Diego, CAcs, Columbia University, New York, NY, U.S.,Columbia Univ, Dept Pediat, Div Mol Genet, New York, NY 10027 USA.4 aut
700a Spracklen, Cassandra N.u Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.; Department of Biostatistics and Epidemiology, University of Massachusetts-Amherst, Amherst, MA, U.S.,Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA.;Univ Massachusetts, Dept Biostat & Epidemiol, Amherst, MA 01003 USA.4 aut
700a Karaderi, Tugceu Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; Department of Biological Sciences, Faculty of Arts and Sciences, Eastern Mediterranean University, Famagusta, Cyprus; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; DTU Health Technology, Technical University of Denmark, Lyngby, Denmark,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Eastern Mediterranean Univ, Fac Arts & Sci, Dept Biol Sci, Gazimagusa, Cyprus.;Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Prot Res, Copenhagen, Denmark.;Tech Univ Denmark, DTU Hlth Technol, Lyngby, Denmark.4 aut
700a Huang, Lam Opalu Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, Copenhagen, Denmark.4 aut
700a Bradfield, Jonathanu Center for Applied Genomics, Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, U.S.; Quantinuum Research LLC, San Diego, CA, U.S.,Childrens Hosp Philadelphia, Div Human Genet, Ctr Appl Gen, Philadelphia, PA 19104 USA.;Quantinuum Res LLC, San Diego, CA USA.4 aut
700a Schurmann, Claudiau The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.,Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.4 aut
700a Fine, Rebecca S.u Department of Genetics, Harvard Medical School, Boston, MA, U.S.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA, U.S.; Broad Institute of MIT and Harvard, Cambridge, MA, U.S.,Harvard Med Sch, Dept Genet, Boston, MA 02115 USA.;Boston Childrens Hosp, Div Endocrinol, Boston, MA USA.;Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA USA.;Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.4 aut
700a Preuss, Michael H.u The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.,Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.,Childrens Hosp Philadelphia, Div Human Genet, Ctr Appl Gen, Philadelphia, PA 19104 USA.;Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA.,Center for Applied Genomics, Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, U.S.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.4 aut
700a Kutalik, Zultanu Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, U.K.; Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland,Univ Exeter, Royal Devon & Exeter Hosp, Genet Complex Traits, Med Sch, Exeter, Devon, England.;Univ Lausanne, Ctr Primary Care & Publ Hlth, Lausanne, Switzerland.;Swiss Inst Bioinformat, Lausanne, Switzerland.4 aut
700a Lind, Larsu Uppsala universitet,Klinisk epidemiologi,Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA.,Columbia Univ, Dept Pediat, Div Mol Genet, New York, NY 10027 USA.,Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K.,Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.,Joseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, U.S.,Department of Medical Sciences, Uppsala University, Uppsala, Sweden,Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.,Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, NY, U.S.4 aut0 (Swepub:uu)larslind
700a Lu, Yingchangu The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, and Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, U.S.,Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Vanderbilt Univ, Sch Med, Dept Med, Div Epidemiol,Vanderbilt Ingram Canc Ctr, Nashville, TN 37212 USA.;Vanderbilt Univ, Sch Med, Vanderbilt Epidemiol Ctr, Nashville, TN 37212 USA.4 aut
700a Metz, Sophiau Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, Copenhagen, Denmark.4 aut
700a Willems, Sara M.u MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K.,Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.,Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England.;Guys & St Thomas Fdn Trust, NIHR Biomed Res Ctr, London, England.,Department of Twin Research and Genetic Epidemiology, Kings College London, London, U.K.; NIHR Biomedical Research Centre at Guy’s and St Thomas’ Foundation Trust, London, U.K.4 aut
700a Li-Gao, Ruifangu Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands,Leiden Univ, Dept Clin Epidemiol, Med Ctr, Leiden, Netherlands.4 aut
700a Grarup, Nielsu Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, Copenhagen, Denmark.4 aut
700a Wang, Shuaiu Department of Biostatistics, Boston University School of Public Health, Boston, MA, U.S.,Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.4 aut
700a Molnos, Sophieu German Center for Diabetes Research, München-Neuherberg, Germany; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, München-Neuherberg, Germany,German Ctr Diabet Res, Munich, Germany.;Ctr Environm Hlth, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen Res, Inst Epidemiol, Munich, Germany.4 aut
700a Sandoval-Zárate, América A.u Institute for Molecular Medicine Finland, Helsinki, Finland,Inst Mol Med Finland, Helsinki, Finland.4 aut
700a Nalls, Mike A.u Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, U.S.; Data Tecnica International, Glen Echo, MD, U.S.,NIA, Lab Neurogenet, NIH, Bethesda, MD 20892 USA.;Data Tecn Int, Glen Echo, MD USA.4 aut
700a Lange, Leslie A.u Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado-Denver, Denver, CO, U.S.,Univ Colorado, Dept Med, Div Biomed Informat & Personalized Med, Denver, CO USA.,Univ Wisconsin, Joseph J Zilber Sch Publ Hlth, Milwaukee, WI 53201 USA.4 aut
700a Haesser, Jeffreyu Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, U.S.,Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.4 aut
700a Guo, Xiuqingu The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, U.S.,Harbor UCLA Med Ctr, Dept Pediat, Lundquist Inst Biomed Innovat, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA.4 aut
700a Lyytikäinen, Leo-Pekkau Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland,Fimlab Labs, Dept Clin Chem, Tampere, Finland.;Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere, Finland.4 aut
700a Feitosa, Maryu Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, U.S.,Washington Univ, Sch Med, Dept Genet, Div Stat Gen, St Louis, MO 63110 USA.4 aut
700a Sitlani, Colleen M.u Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, U.S.,Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.4 aut
700a Venturini, Cristinau Department of Twin Research and Genetic Epidemiology, Kings College London, London, U.K.,Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England.4 aut
700a Mahajan, Anubhau Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Radcliffe Dept Med, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.4 aut
700a Kacprowski, Timu Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany,Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Dept Funct Genom, Greifswald, Germany.;DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.4 aut
700a Wang, Carol A.u Department of Biostatistics, Boston University School of Public Health, Boston, MA, U.S.,Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.4 aut
700a Chasman, Daniel I.u Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA, U.S.; Harvard Medical School, Boston, MA, U.S.,Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.4 aut
700a Amin, Najafu Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands,Erasmus MC, Univ Med Ctr Rotterdam, Dept Epidemiol, Rotterdam, Netherlands.4 aut
700a Broer, Lindau Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands4 aut
700a Robertson, Neilu Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Radcliffe Dept Med, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.4 aut
700a Young, Kristin L.u Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.,Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27515 USA.4 aut
700a Allison, Matthewu Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, U.S.,Univ Calif San Diego, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USA.4 aut
700a Auer, Paul L.u Joseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, U.S.4 aut
700a Blüher, Matthiasu Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany,Univ Leipzig, Med Dept Endocrinol 3, Nephrol, Med Ctr,Rheumatol, Leipzig, Germany.4 aut
700a Borja, Judith B.u Office of Population Studies Foundation, Inc., Cebu City, Philippines; Department of Nutrition and Dietetics, University of San Carlos, Cebu City, Philippines,Off Populat Studies Fdn Inc, Cebu, Philippines.;Univ San Carlos, Dept Nutr & Dietet, Cebu, Philippines.4 aut
700a Bork-Jensen, Jetteu Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, Copenhagen, Denmark.4 aut
700a Carrasquilla, Germán D.u Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, Copenhagen, Denmark.4 aut
700a Christofidou, Paraskeviu Department of Twin Research and Genetic Epidemiology, Kings College London, London, U.K.,Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England.4 aut
700a Demirkan, Ayseu Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands,Erasmus MC, Univ Med Ctr Rotterdam, Dept Epidemiol, Rotterdam, Netherlands.4 aut
700a Doege, Claudia A.u Department of Pathology and Cell Biology, Columbia University, New York, NY, U.S.,Columbia Univ, Dept Pathol & Cell Biol, New York, NY USA.4 aut
700a Garcia, Melissa E.u Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, U.S.,NIA, Lab Epidemiol & Populat Sci, Bethesda, MD 20892 USA.4 aut
700a Graff, Mariaelisau Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.; Carolina Center for Genome Sciences, Chapel Hill, NC, U.S.,Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27515 USA.;Carolina Ctr Genome Sci, Chapel Hill, NC USA.4 aut
700a Guo, Kaiyingu Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, NY, U.S.,Columbia Univ, Dept Pediat, Div Mol Genet, New York, NY 10027 USA.4 aut
700a Hakonarson, Hakonu Center for Applied Genomics, Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, U.S.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.4 aut
700a Hong, Jaeyoungu Department of Biostatistics, Boston University School of Public Health, Boston, MA, U.S.,Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.4 aut
700a Chen, Yii-Der Idau The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, U.S.,Harbor UCLA Med Ctr, Dept Pediat, Lundquist Inst Biomed Innovat, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA.4 aut
700a Jackson, Rebeccau Division of Endocrinology, Diabetes, and Metabolism, Ohio State University, Columbus, OH, U.S.,Ohio State Univ, Div Endocrinol Diabet & Metab, Columbus, OH 43210 USA.4 aut
700a Jakupović, Herminau Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, Copenhagen, Denmark.4 aut
700a Jousilahti, Pekkau Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland,Finnish Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland.4 aut
700a Justice, Anne E.u Center for Biomedical and Translational Informatics, Geisinger, Danville, PA, U.S.,Ctr Biomed & Translat Informat, Danville, PA USA.4 aut
700a Kähönen, Mikau Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland; Department of Clinical Physiology, Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland,Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland.;Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Physiol, Tampere, Finland.4 aut
700a Kizer, Jorge R.u Cardiology Section, San Francisco Veterans Affairs Health Care System, University of California San Francisco, San Francisco, CA, U.S.; Departments of Medicine and Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, U.S.,Univ Calif San Francisco, San Francisco Vet Affairs Hlth Care Syst, Cardiol Sect, San Francisco, CA 94143 USA.;Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA.;Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.4 aut
700a Kriebel, Jenniferu German Center for Diabetes Research, München-Neuherberg, Germany; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, München-Neuherberg, Germany,German Ctr Diabet Res, Munich, Germany.;Ctr Environm Hlth, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen Res, Inst Epidemiol, Munich, Germany.4 aut
700a LeDuc, Charles A.u Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, NY, U.S.,Columbia Univ, Dept Pediat, Div Mol Genet, New York, NY 10027 USA.4 aut
700a Li, Jinu Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Palo Alto, CA, U.S.,Stanford Univ, Dept Med, Div Cardiovasc Med, Palo Alto, CA 94304 USA.4 aut
700a Lind, Larsu Department of Medical Sciences, Uppsala University, Uppsala, Sweden4 aut
700a Luan, Jian'anu MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K.,Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.4 aut
700a Mackey, David A.u Centre for Ophthalmology and Visual Science, Lions Eye Institute, The University of Western Australia, Perth, West Australia, Australia,Univ Western Australia, Lions Eye Inst, Ctr Ophthalmol & Visual Sci, Perth, WA, Australia.4 aut
700a Mangino, Massimou Department of Twin Research and Genetic Epidemiology, Kings College London, London, U.K.; NIHR Biomedical Research Centre at Guy’s and St Thomas’ Foundation Trust, London, U.K.,Univ Washington, Dept Epidemiol, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.;Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.;Univ Washington, Dept Hlth Serv, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.;Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA.,Erasmus MC, Univ Med Ctr Rotterdam, Dept Epidemiol, Rotterdam, Netherlands.;Erasmus MC, Univ Med Ctr Rotterdam, Dept Internal Med, Rotterdam, Netherlands.,Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.,Univ Exeter, Royal Devon & Exeter Hosp, Genet Complex Traits, Med Sch, Exeter, Devon, England.,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Univ Oxford, Big Data Inst, Nuffield Dept Med, Oxford, England.,Cardiovascular Health Research Unit, Departments of Epidemiology, Medicine, and Health Services, University of Washington, Seattle, WA, U.S.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, U.S.,Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands,Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA, U.S.; Harvard Medical School, Boston, MA, U.S.,Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, U.K.,Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; Broad Institute of MIT and Harvard, Cambridge, MA, U.S.; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.4 aut
700a Männistö, Satuu Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland,Finnish Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland.4 aut
700a Martin Carli, Jayne F.u Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, NY, U.S.,Columbia Univ, Dept Pediat, Div Mol Genet, New York, NY 10027 USA.4 aut
700a Medina-Gomez, Carolinau Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands,Erasmus MC, Univ Med Ctr Rotterdam, Dept Epidemiol, Rotterdam, Netherlands.;Erasmus MC, Univ Med Ctr Rotterdam, Dept Internal Med, Rotterdam, Netherlands.4 aut
700a Mook-Kanamori, Dennisu Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands,Leiden Univ, Dept Clin Epidemiol, Med Ctr, Leiden, Netherlands.;Leiden Univ, Dept Publ Hlth & Primary Care, Med Ctr, Leiden, Netherlands.4 aut
700a Morris, Andrew P.u Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; Department of Biostatistics, University of Liverpool, Liverpool, U.K.; Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, U.K.,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England.;Univ Manchester, Div Musculoskeletal & Dermatol Sci, Manchester, Lancs, England.4 aut
700a de Mutsert, Renéeu Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands,Leiden Univ, Dept Clin Epidemiol, Med Ctr, Leiden, Netherlands.4 aut
700a Nauck, Matthiasu DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany,DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.;Univ Med Greifswald, Inst Clin Chem & Lab Med, Greifswald, Germany.4 aut
700a Prokic, Ivanau Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands,Erasmus MC, Univ Med Ctr Rotterdam, Dept Epidemiol, Rotterdam, Netherlands.4 aut
700a Pennell, Craig E.u Department of Biostatistics, Boston University School of Public Health, Boston, MA, U.S.,Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.4 aut
700a Pradhan, Arund D.u Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA, U.S.; Harvard Medical School, Boston, MA, U.S.,Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.4 aut
700a Psaty, Bruce M.u Cardiovascular Health Research Unit, Departments of Epidemiology, Medicine, and Health Services, University of Washington, Seattle, WA, U.S.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, U.S.4 aut
700a Raitakari, Olli T.u Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, Turku University Hospital, Turku, Finland,Univ Turku, Ctr Populat Hlth Res, Turku, Finland.;Turku Univ Hosp, Turku, Finland.;Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku, Finland.;Turku Univ Hosp, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland.4 aut
700a Scott, Robert A.u MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K.,Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.4 aut
700a Skaaby, Teau Center for Clinical Research and Disease Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark,Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Dis Prevent, Copenhagen, Denmark.4 aut
700a Strauch, Konstantinu Institute of Genetic Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany; Chair of Genetic Epidemiology, Insitute of Medical Information Processing, Biometry, and Epidemiology (IBE), Faculty of Medicine, Ludwig Maximilian University Munich, München, Germany,German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Genet Epidemiol, Neuherberg, Germany.;Ludwig Maximilian Univ Munich, Fac Med, Inst Med Informat Proc Biometry & Epidemiol IBE, Chair Genet Epidemiol, Munich, Germany.4 aut
700a Taylor, Kent D.u The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA,Harbor UCLA Med Ctr, Dept Pediat, Lundquist Inst Biomed Innovat, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA.4 aut
700a Teumer, Alexanderu DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany,DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.;Univ Med Greifswald, Inst Community Med, Greifswald, Germany.4 aut
700a Uitterlinden, Andre G.u Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands,Erasmus MC, Univ Med Ctr Rotterdam, Dept Epidemiol, Rotterdam, Netherlands.;Erasmus MC, Univ Med Ctr Rotterdam, Dept Internal Med, Rotterdam, Netherlands.4 aut
700a Wu, Yingu Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.,Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA.4 aut
700a Yao, Jieu The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, U.S.,Harbor UCLA Med Ctr, Dept Pediat, Lundquist Inst Biomed Innovat, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA.4 aut
700a Walker, Marku Institute of Cellular Medicine (Diabetes), Newcastle University, Newcastle upon Tyne, U.K.,Newcastle Univ, Inst Cellular Med Diabet, Newcastle Upon Tyne, Tyne & Wear, England.4 aut
700a North, Kari E.u Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.,Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27515 USA.4 aut
700a Kovacs, Peteru Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany,Univ Leipzig, Med Dept Endocrinol 3, Nephrol, Med Ctr,Rheumatol, Leipzig, Germany.4 aut
700a Ikram, M. Arfanu Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands4 aut
700a van Duijn, Cornelia M.u Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands4 aut
700a Ridker, Paul M.u Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA, U.S.; Harvard Medical School, Boston, MA, U.S.4 aut
700a Lye, Stephenu Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada,Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada.4 aut
700a Homuth, Georgu Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany,Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Dept Funct Genom, Greifswald, Germany.4 aut
700a Ingelsson, Eriku Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Palo Alto, CA, U.S.; Stanford Cardiovascular Institute, Stanford University School of Medicine, Palo Alto, CA, U.S.; Stanford Diabetes Research Center, Stanford University, Stanford, CA, U.S.; Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden,Stanford Univ, Dept Med, Div Cardiovasc Med, Palo Alto, CA 94304 USA.;Stanford Univ, Sch Med, Stanford Cardiovasc Inst, Palo Alto, CA 94304 USA.;Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA.;Uppsala Univ, Dept Med Sci, Mol Epidemiol & Sci Life Lab, Uppsala, Sweden.4 aut
700a Spector, Tim D.u Department of Twin Research and Genetic Epidemiology, Kings College London, London, U.K.,Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England.4 aut
700a McKnight, Barbarau Department of Biostatistics, University of Washington, Seattle, WA, U.S.,Univ Washington, Dept Biostat, Seattle, WA 98195 USA.4 aut
700a Province, Michael A.u Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, U.S.,Washington Univ, Sch Med, Dept Genet, Div Stat Gen, St Louis, MO 63110 USA.4 aut
700a Lehtimäki, Terhou Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland,Fimlab Labs, Dept Clin Chem, Tampere, Finland.;Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere, Finland.4 aut
700a Adair, Linda S.u Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.,Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC 27515 USA.4 aut
700a Rotter, Jerome I.u The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, U.S.,Harbor UCLA Med Ctr, Dept Pediat, Lundquist Inst Biomed Innovat, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA.4 aut
700a Reiner, Alexander P.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, U.S.,Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.4 aut
700a Wilson, James G.u Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, U.S.,Univ Mississippi, Med Ctr, Dept Phys & Biophys, Jackson, MS 39216 USA.4 aut
700a Harris, Tamara B.u Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, U.S.,NIA, Lab Epidemiol & Populat Sci, NIH, Bethesda, MD 20892 USA.4 aut
700a Ripatti, Samuliu Broad Institute of MIT and Harvard, Cambridge, MA, U.S.; Institute for Molecular Medicine Finland, Helsinki, Finland; Public Health, University of Helsinki, Helsinki, Finland,Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Inst Mol Med Finland, Helsinki, Finland.;Univ Helsinki, Publ Hlth, Helsinki, Finland.4 aut
700a Grallert, Haraldu German Center for Diabetes Research, München-Neuherberg, Germany; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, München-Neuherberg, Germany,German Ctr Diabet Res, Munich, Germany.;Ctr Environm Hlth, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen Res, Inst Epidemiol, Munich, Germany.4 aut
700a Meigs, James B.u Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, U.S.; Department of Medicine, Harvard Medical School, Boston, MA, U.S.; Program in Population and Medical Genetics, Broad Institute of MIT and Harvard, Cambridge, MA,Massachusetts Gen Hosp, Div Gen Internal Med, Boston, MA 02114 USA.;Harvard Med Sch, Dept Med, Boston, MA 02115 USA.;Broad Inst MIT & Harvard, Program Populat & Med Genet, Cambridge, MA 02142 USA.4 aut
700a Salomaa, Veikkou Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland,Finnish Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland.4 aut
700a Hansen, Torbenu Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, Copenhagen, Denmark.4 aut
700a van Dijk, Ko Willemsu Division of Endocrinology, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, the Netherlands; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands,Leiden Univ, Med Ctr, Dept Internal Med, Div Endocrinol, Leiden, Netherlands.;Einthoven Lab Expt Vasc Med, Leiden, Netherlands.;Leiden Univ, Dept Human Genet, Med Ctr, Leiden, Netherlands.4 aut
700a Wareham, Nicholas J.u MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K.,Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.4 aut
700a Grant, Struan F.A.u Center for Applied Genomics, Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, U.S.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.; Center for Spatial and Functional Genomics, Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, U.S.; Division of Endocrinology and Diabetes, The Children’s Hospital of Philadelphia, Philadelphia, PA, U.S.; Institute of Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.,Childrens Hosp Philadelphia, Div Human Genet, Ctr Appl Gen, Philadelphia, PA 19104 USA.;Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA.;Childrens Hosp Philadelphia, Div Human Genet, Ctr Spatial & Funct Genom, Philadelphia, PA 19104 USA.;Childrens Hosp Philadelphia, Div Endocrinol & Diabet, Philadelphia, PA 19104 USA.;Univ Penn, Inst Diabet Obes & Metab, Perelman Sch Med, Philadelphia, PA 19104 USA.4 aut
700a Langenberg, Claudiau MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K.,Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.4 aut
700a Frayling, Timothy M.u Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, U.K.4 aut
700a Lindgren, Cecilia M.u Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; Broad Institute of MIT and Harvard, Cambridge, MA, U.S.; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.4 aut
700a Mohlke, Karen L.u Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.4 aut
700a Leibel, Rudolph L.u Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, NY, U.S.4 aut
700a Loos, Ruth J.F.u The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, U.S; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.,Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA.4 aut
700a Kilpeläinen, Tuomas O.u Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.,Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, Copenhagen, Denmark.;Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA.4 aut
710a Luleå tekniska universitetb Medicinsk vetenskap4 org
773t Diabetesd : American Diabetes Associationg 69:12, s. 2806-2818q 69:12<2806-2818x 0012-1797x 1939-327X
856u https://doi.org/10.2337/db20-0070y Fulltext
856u https://diabetes.diabetesjournals.org/content/diabetes/69/12/2806.full.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-82754
8564 8u https://doi.org/10.2337/db20-0070
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-429065

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