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  • Chauvier, D (author)

Targeting neonatal ischemic brain injury with a pentapeptide-based irreversible caspase inhibitor.

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2011-09-01
  • Springer Science and Business Media LLC,2011

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/146664
  • https://gup.ub.gu.se/publication/146664URI
  • https://doi.org/10.1038/cddis.2011.87DOI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Brain protection of the newborn remains a challenging priority and represents a totally unmet medical need. Pharmacological inhibition of caspases appears as a promising strategy for neuroprotection. In a translational perspective, we have developed a pentapeptide-based group II caspase inhibitor, TRP601/ORPHA133563, which reaches the brain, and inhibits caspases activation, mitochondrial release of cytochrome c, and apoptosis in vivo. Single administration of TRP601 protects newborn rodent brain against excitotoxicity, hypoxia-ischemia, and perinatal arterial stroke with a 6-h therapeutic time window, and has no adverse effects on physiological parameters. Safety pharmacology investigations, and toxicology studies in rodent and canine neonates, suggest that TRP601 is a lead compound for further drug development to treat ischemic brain damage in human newborns.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Renolleau, S (author)
  • Holifanjaniaina, S (author)
  • Ankri, S (author)
  • Bezault, M (author)
  • Schwendimann, L (author)
  • Rousset, Catherine,1977Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xrousc (author)
  • Casimir, R (author)
  • Hoebeke, Johan (author)
  • Smirnova, M (author)
  • Debret, G (author)
  • Trichet, A-P (author)
  • Carlsson, Ylva,1975Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xcarly (author)
  • Wang, Xiaoyang,1965Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation(Swepub:gu)xwanxi (author)
  • Bernard, E (author)
  • Hébert, M (author)
  • Rauzier, J-M (author)
  • Matecki, S (author)
  • Lacampagne, A (author)
  • Rustin, P (author)
  • Mariani, J (author)
  • Hagberg, Henrik,1955Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xhaghe (author)
  • Gressens, P (author)
  • Charriaut-Marlangue, C (author)
  • Jacotot, E (author)
  • Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för fysiologi (creator_code:org_t)

Related titles

  • In:Cell death & disease: Springer Science and Business Media LLC22041-4889

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