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FältnamnIndikatorerMetadata
00008609naa a2200769 4500
001oai:DiVA.org:uu-478260
003SwePub
008220622s2022 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-196823
009oai:prod.swepub.kib.ki.se:150575614
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4782602 URI
0247 a https://doi.org/10.1530/EC-22-00242 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1968232 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1505756142 URI
040 a (SwePub)uud (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Vogt, Elinor Chelsomu Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway4 aut
2451 0a Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts
264 1b Bioscientifica,c 2022
338 a electronic2 rdacarrier
520 a Objective: To investigate markers of premature menopause (<40 years) and specifically the prevalence of autoimmune primary ovarian insufficiency (POI) in European women.Design: Postmenopausal women were categorized according to age at menopause and self-reported reason for menopause in a cross-sectional analysis of 6870 women.Methods: Variables associated with the timing of menopause and hormone measurements of 17β-estradiol and follicle-stimulating hormone were explored using multivariable logistic regression analysis. Specific immunoprecipitating assays of steroidogenic autoantibodies against 21-hydroxylase (21-OH), side-chain cleavage enzyme (anti-SCC) and 17alpha-hydroxylase (17 OH), as well as NACHT leucine-rich-repeat protein 5 were used to identify women with likely autoimmune POI.Results: Premature menopause was identified in 2.8% of women, and these women had higher frequencies of nulliparity (37.4% vs 19.7%), obesity (28.7% vs 21.4%), osteoporosis (17.1% vs 11.6%), hormone replacement therapy (59.1% vs 36.9%) and never smokers (60.1% vs 50.9%) (P < 0.05), compared to women with menopause ≥40 years. Iatrogenic causes were found in 91 (47%) and non-ovarian causes in 27 (14%) women, while 77 (39%) women were classified as POI of unknown cause, resulting in a 1.1% prevalence of idiopathic POI. After adjustments nulliparity was the only variable significantly associated with POI (odds ratio 2.46; 95% CI 1.63-3.42). Based on the presence of autoantibodies against 21 OH and SCC, 4.5% of POI cases were of likely autoimmune origin.Conclusion: Idiopathic POI affects 1.1% of all women and almost half of the women with premature menopause. Autoimmunity explains 4.5% of these cases judged by positive steroidogenic autoantibodies.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
653 a autoimmune
653 a premature menopause
653 a premature ovarian failure
653 a premature ovarian insufficiency
653 a primary ovarian insufficiency
653 a Physiology
653 a Fysiologi
7001 a Real, Francisco Gómezu Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway4 aut
7001 a Husebye, Eystein Sverreu Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway4 aut
7001 a Björnsdottir, Sigriduru Karolinska Institutet4 aut
7001 a Benediktsdottir, Bryndisu Medical Faculty, University of Iceland, Reykjavik, Iceland; Department of Sleep, Landspitali University Hospital Reykjavík, Reykjavik, Iceland4 aut
7001 a Bertelsen, Randi Jacobsenu Department of Clinical Science, University of Bergen, Bergen, Norway4 aut
7001 a Demoly, Pascalu University Hospital of Montpellier, IDESP, Univ Montpellier-Inserm, Montpellier, France4 aut
7001 a Franklin, Karl Andersu Umeå universitet,Kirurgi4 aut0 (Swepub:umu)kafr0021
7001 a de Aja Gallastegui, Leire Sainzu Unit of Epidemiology and Public Health, Department of Health, Basque Government, Vitoria-Gasteiz, Spain4 aut
7001 a González, Francisco Javier Callejasu Department of Respiratory Medicine, Albacete University Hospital, Albacete, Spain4 aut
7001 a Heinrich, Joachimu Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich, Germany; Allergy and Lung Health Unit, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia4 aut
7001 a Holm, Mathiasu Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden4 aut
7001 a Jogi, Nils Oscaru Department of Clinical Science, University of Bergen, Bergen, Norway4 aut
7001 a Leynaert, Benedicteu Université Paris-Saclay, Inserm U1018, Center for Epidemiology and Population Health, Integrative Respiratory Epidemiology Team, Villejuif, France4 aut
7001 a Lindberg, Evau Uppsala universitet,Lung- allergi- och sömnforskning,Department of Medical Sciences, Respiratory, Allergy and Sleep Medicine, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)evalb
7001 a Malinovschi, Andrei,d 1978-u Uppsala universitet,Klinisk fysiologi,Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)anmal535
7001 a Martínez-Moratalla, Jesúsu Pneumology Service of the General University Hospital of Albacete, Albacete, Spain; Albacete Faculty of Medicine, Castilla-La Mancha University, Albacete, Spain4 aut
7001 a Mayoral, Raúl Godoyu Department of Respiratory Medicine, Albacete University Hospital, Albacete, Spain4 aut
7001 a Oudin, Annau Umeå universitet,Avdelningen för hållbar hälsa4 aut0 (Swepub:umu)anou0004
7001 a Pereira-Vega, Antoniou Juan Ramón Jiménez University Hospital in Huelva, Huelva, Spain4 aut
7001 a Semjen, Chantal Raherisonu INSERM, EpiCene Team U1219, University of Bordeaux, Talence, France4 aut
7001 a Schlünssen, Viviu Department of Public Health, Environment, Work and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark; The National Research Center for the Working Environment, Copenhagen, Denmark4 aut
7001 a Triebner, Kaiu Department of Clinical Science, University of Bergen, Bergen, Norway4 aut
7001 a Øksnes, Marianneu Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway4 aut
7102 a Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norwayb Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway4 org
7730 t Endocrine Connectionsd : Bioscientificag 11:5q 11:5x 2049-3614
8564 u https://doi.org/10.1530/EC-22-0024y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1674673/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://umu.diva-portal.org/smash/get/diva2:1673189/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-478260
8564 8u https://doi.org/10.1530/EC-22-0024
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-196823
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:150575614

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