A genome-wide association study of social trust in 33,882 Danish blood donors

Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
Blood Donors
Denmark
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Phenotype
Polymorphism, Single Nucleotide
Trust
blood donor
genetic predisposition
genome-wide association study
human
meta analysis
phenotype
single nucleotide polymorphism
trust

Kalamajski, S.Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)se8335ka (författare)
Giordano, G.N.Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-geg (författare)
Pedersen, O.B.V.University of Copenhagen (författare)
University of CopenhagenGenetisk och molekylär epidemiologi (creator_code:org_t)
DBDS Genomic Consortium

Av författaren/redakt...: Sequeros, C.B.; Kalamajski, S.; Giordano, G.N.; Pedersen, O.B.V.

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