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Consistent success ...
Consistent success in life-supporting porcine cardiac xenotransplantation
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- Längin, Matthias (author)
- University Hospital Munich,Ludwig-Maximilian University of Munich
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- Mayr, Tanja (author)
- University Hospital Munich
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- Reichart, Bruno (author)
- Ludwig-Maximilian University of Munich
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- Michel, Sebastian (author)
- University Hospital Munich
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- Buchholz, Stefan (author)
- University Hospital Munich
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- Guethoff, Sonja (author)
- University Hospital Munich,Ludwig-Maximilian University of Munich
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- Dashkevich, Alexey (author)
- University Hospital Munich
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- Baehr, Andrea (author)
- Ludwig-Maximilian University of Munich
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- Egerer, Stefanie (author)
- Ludwig-Maximilian University of Munich
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- Bauer, Andreas (author)
- University Hospital Munich
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- Mihalj, Maks (author)
- University Hospital Munich
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- Panelli, Alessandro (author)
- Ludwig-Maximilian University of Munich
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- Issl, Lara (author)
- Ludwig-Maximilian University of Munich
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- Ying, Jiawei (author)
- Ludwig-Maximilian University of Munich
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- Fresch, Ann Kathrin (author)
- Ludwig-Maximilian University of Munich
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- Buttgereit, Ines (author)
- Ludwig-Maximilian University of Munich
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- Mokelke, Maren (author)
- Ludwig-Maximilian University of Munich
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- Radan, Julia (author)
- Ludwig-Maximilian University of Munich
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- Werner, Fabian (author)
- University Hospital Munich
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- Lutzmann, Isabelle (author)
- Ludwig-Maximilian University of Munich
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- Steen, Stig (author)
- Lund University,Lunds universitet,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Heart and Lung transplantation,Lund University Research Groups,Skåne University Hospital
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- Sjöberg, Trygve (author)
- Lund University,Lunds universitet,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Heart and Lung transplantation,Lund University Research Groups,Skåne University Hospital
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- Paskevicius, Audrius (author)
- Lund University,Lunds universitet,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Heart and Lung transplantation,Lund University Research Groups,Skåne University Hospital
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- Qiuming, Liao (author)
- Lund University,Lunds universitet,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Heart and Lung transplantation,Lund University Research Groups,Skåne University Hospital
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- Sfriso, Riccardo (author)
- University of Bern
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- Rieben, Robert (author)
- University of Bern
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- Dahlhoff, Maik (author)
- Ludwig-Maximilian University of Munich
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- Kessler, Barbara (author)
- Ludwig-Maximilian University of Munich
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- Kemter, Elisabeth (author)
- Ludwig-Maximilian University of Munich
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- Klett, Katharina (author)
- German Centre for Cardiovascular Research,Klinikum rechts der Isar,Ludwig-Maximilian University of Munich
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- Hinkel, Rabea (author)
- German Centre for Cardiovascular Research,Klinikum rechts der Isar,Ludwig-Maximilian University of Munich
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- Kupatt, Christian (author)
- Klinikum rechts der Isar,German Centre for Cardiovascular Research
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- Falkenau, Almuth (author)
- Ludwig-Maximilian University of Munich
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- Reu, Simone (author)
- Ludwig-Maximilian University of Munich
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- Ellgass, Reinhard (author)
- University Hospital Munich
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- Herzog, Rudolf (author)
- University Hospital Munich
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- Binder, Uli (author)
- XL-protein GmbH
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- Wich, Günter (author)
- Wacker-Chemie AG
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- Skerra, Arne (author)
- Technical University of Munich
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- Ayares, David (author)
- Revivicor, Inc
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- Kind, Alexander (author)
- Technical University of Munich
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- Schönmann, Uwe (author)
- German Primate Center
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- Kaup, Franz Josef (author)
- German Primate Center
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- Hagl, Christian (author)
- University Hospital Munich
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- Wolf, Eckhard (author)
- Ludwig-Maximilian University of Munich
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- Klymiuk, Nikolai (author)
- Ludwig-Maximilian University of Munich
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- Brenner, Paolo (author)
- University Hospital Munich,Ludwig-Maximilian University of Munich
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- Abicht, Jan Michael (author)
- University Hospital Munich,Ludwig-Maximilian University of Munich
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(creator_code:org_t)
- 2018-12-05
- 2018
- English 4 s.
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 564:7736, s. 430-433
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Heart transplantation is the only cure for patients with terminal cardiac failure, but the supply of allogeneic donor organs falls far short of the clinical need1–3. Xenotransplantation of genetically modified pig hearts has been discussed as a potential alternative4. Genetically multi-modified pig hearts that lack galactose-α1,3-galactose epitopes (α1,3-galactosyltransferase knockout) and express a human membrane cofactor protein (CD46) and human thrombomodulin have survived for up to 945 days after heterotopic abdominal transplantation in baboons5. This model demonstrated long-term acceptance of discordant xenografts with safe immunosuppression but did not predict their life-supporting function. Despite 25 years of extensive research, the maximum survival of a baboon after heart replacement with a porcine xenograft was only 57 days and this was achieved, to our knowledge, only once6. Here we show that α1,3-galactosyltransferase-knockout pig hearts that express human CD46 and thrombomodulin require non-ischaemic preservation with continuous perfusion and control of post-transplantation growth to ensure long-term orthotopic function of the xenograft in baboons, the most stringent preclinical xenotransplantation model. Consistent life-supporting function of xenografted hearts for up to 195 days is a milestone on the way to clinical cardiac xenotransplantation7.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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Nature
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To the university's database
- By the author/editor
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Längin, Matthias
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Mayr, Tanja
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Reichart, Bruno
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Michel, Sebastia ...
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Buchholz, Stefan
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Guethoff, Sonja
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show more...
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Dashkevich, Alex ...
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Baehr, Andrea
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Egerer, Stefanie
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Bauer, Andreas
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Mihalj, Maks
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Panelli, Alessan ...
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Issl, Lara
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Ying, Jiawei
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Fresch, Ann Kath ...
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Buttgereit, Ines
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Mokelke, Maren
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Radan, Julia
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Werner, Fabian
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Lutzmann, Isabel ...
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Steen, Stig
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Sjöberg, Trygve
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Paskevicius, Aud ...
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Qiuming, Liao
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Sfriso, Riccardo
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Rieben, Robert
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Dahlhoff, Maik
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Kessler, Barbara
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Kemter, Elisabet ...
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Klett, Katharina
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Hinkel, Rabea
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Kupatt, Christia ...
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Falkenau, Almuth
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Reu, Simone
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Ellgass, Reinhar ...
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Herzog, Rudolf
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Binder, Uli
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Wich, Günter
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Skerra, Arne
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Ayares, David
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Kind, Alexander
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Schönmann, Uwe
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Kaup, Franz Jose ...
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Hagl, Christian
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Wolf, Eckhard
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Klymiuk, Nikolai
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Brenner, Paolo
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Abicht, Jan Mich ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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Nature
- By the university
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Lund University