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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004201naa a2200601 4500
001oai:gup.ub.gu.se/234966
003SwePub
008240528s2016 | |||||||||||000 ||eng|
024a https://gup.ub.gu.se/publication/2349662 URI
024a https://doi.org/10.1111/epi.133192 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Blumcke, I.4 aut
2451 0a International recommendation for a comprehensive neuropathologic workup of epilepsy surgery brain tissue: A consensus Task Force report from the ILAE Commission on Diagnostic Methods
264 c 2016-02-03
264 1b Wiley,c 2016
520 a Epilepsy surgery is an effective treatment in many patients with drug-resistant focal epilepsies. An early decision for surgical therapy is facilitated by a magnetic resonance imaging (MRI)visible brain lesion congruent with the electrophysiologically abnormal brain region. Recent advances in the pathologic diagnosis and classification of epileptogenic brain lesions are helpful for clinical correlation, outcome stratification, and patient management. However, application of international consensus classification systems to common epileptic pathologies (e.g., focal cortical dysplasia [FCD] and hippocampal sclerosis [HS]) necessitates standardized protocols for neuropathologic workup of epilepsy surgery specimens. To this end, the Task Force of Neuropathology from the International League Against Epilepsy (ILAE) Commission on Diagnostic Methods developed a consensus standard operational procedure for tissue inspection, distribution, and processing. The aims are to provide a systematic framework for histopathologic workup, meeting minimal standards and maximizing current and future opportunities for morphofunctional correlations and molecular studies for both clinical care and research. Whenever feasible, anatomically intact surgical specimens are desirable to enable systematic analysis in selective hippocampectomies, temporal lobe resections, and lesional or nonlesional neocortical samples. Correct orientation of sample and the sample's relation to neurophysiologically aberrant sites requires good communication between pathology and neurosurgical teams. Systematic tissue sampling of 5-mm slabs along a defined anatomic axis and application of a limited immunohistochemical panel will ensure a reliable differential diagnosis of main pathologies encountered in epilepsy surgery.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653 a Brain
653 a Neuropathology
653 a Epilepsy
653 a Seizure
653 a Malformation
653 a Tumor
653 a Encephalitis
653 a Neuron
653 a Glia
653 a TEMPORAL-LOBE EPILEPSY
653 a FOCAL CORTICAL DYSPLASIAS
653 a CLASSIFICATION
653 a TUMORS
653 a EXPERIENCE
653 a OUTCOMES
653 a SYSTEM
700a Aronica, E.4 aut
700a Miyata, H.4 aut
700a Sarnat, H. B.4 aut
700a Thom, M.4 aut
700a Roessler, K.4 aut
700a Rydenhag, Bertil,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation4 aut0 (Swepub:gu)xrydbe
700a Jehi, L.4 aut
700a Krsek, P.4 aut
700a Wiebe, S.4 aut
700a Spreafico, R.4 aut
710a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering4 org
773t Epilepsiad : Wileyg 57:3, s. 348-358q 57:3<348-358x 0013-9580
856u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/epi.13319
8564 8u https://gup.ub.gu.se/publication/234966
8564 8u https://doi.org/10.1111/epi.13319

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