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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008183naa a2200493 4500
001oai:DiVA.org:his-20791
003SwePub
008211216s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-207912 URI
0247 a https://doi.org/10.1097/EJA.00000000000015912 DOI
040 a (SwePub)his
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Nummela, Aleksi J.u Department of Peri-operative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland ; Department of Internal Medicine, Turku University Hospital, Finland4 aut
2451 0a Effects of dexmedetomidine, propofol, sevoflurane and S-ketamine on the human metabolome :b A randomised trial using nuclear magnetic resonance spectroscopy
264 1b Wolters Kluwer,c 2022
338 a electronic2 rdacarrier
500 a CC BY 4.0September 15, 2021Correspondence to Aleksi J. Nummela, Department of Internal Medicine, Turku University Hospital, 20521 Turku, Finland E-mail: aljunu@utu.fiFinancial support and sponsorship: this work was supported by Academy of Finland, Helsinki, Finland (grant numbers 266467, 266434); Jane and Aatos Erkko Foundation, Helsinki, Finland; The Finnish Medical Foundation, Helsinki, Finland (JWL); The Emil Aaltonen Foundation, Tampere, Finland (JWL); and The Paulo Foundation, Espoo, Finland (LTL) and Orion Research Foundation, Espoo, Finland (LTL); Signe and Ane Gyllenberg Foundation, Helsinki, Finland (KJV); The Finnish Medical Foundation, Eero Matti Raninen Fund, Helsinki, Finland (AJN) and University of Turku, Finland (AJN).
520 a BACKGROUND: Pharmacometabolomics uses large-scale data capturing methods to uncover drug-induced shifts in the metabolic profile. The specific effects of anaesthetics on the human metabolome are largely unknown.OBJECTIVE: We aimed to discover whether exposure to routinely used anaesthetics have an acute effect on the human metabolic profile.DESIGN: Randomised, open-label, controlled, parallel group, phase IV clinical drug trial.SETTING: The study was conducted at Turku PET Centre, University of Turku, Finland, 2016 to 2017.PARTICIPANTS: One hundred and sixty healthy male volunteers were recruited. The metabolomic data of 159 were evaluable.INTERVENTIONS: Volunteers were randomised to receive a 1-h exposure to equipotent doses (EC50 for verbal command) of dexmedetomidine (1.5 ng ml-1; n = 40), propofol (1.7 μg ml-1; n = 40), sevoflurane (0.9% end-tidal; n = 39), S-ketamine (0.75 μg ml-1; n = 20) or placebo (n = 20).MAIN OUTCOME MEASURES: Metabolite subgroups of apolipoproteins and lipoproteins, cholesterol, glycerides and phospholipids, fatty acids, glycolysis, amino acids, ketone bodies, creatinine and albumin and the inflammatory marker GlycA, were analysed with nuclear magnetic resonance spectroscopy from arterial blood samples collected at baseline, after anaesthetic administration and 70 min postanaesthesia.RESULTS: All metabolite subgroups were affected. Statistically significant changes vs. placebo were observed in 11.0, 41.3, 0.65 and 3.9% of the 155 analytes in the dexmedetomidine, propofol, sevoflurane and S-ketamine groups, respectively. Dexmedetomidine increased glucose, decreased ketone bodies and affected lipoproteins and apolipoproteins. Propofol altered lipoproteins, fatty acids, glycerides and phospholipids and slightly increased inflammatory marker glycoprotein acetylation. Sevoflurane was relatively inert. S-ketamine increased glucose and lactate, whereas branched chain amino acids and tyrosine decreased.CONCLUSION: A 1-h exposure to moderate doses of routinely used anaesthetics led to significant and characteristic alterations in the metabolic profile. Dexmedetomidine-induced alterations mirror α2-adrenoceptor agonism. Propofol emulsion altered the lipid profile. The inertness of sevoflurane might prove useful in vulnerable patients. S-ketamine induced amino acid alterations might be linked to its suggested antidepressive properties.TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT02624401. URL: https://clinicaltrials.gov/ct2/show/NCT02624401.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Anestesi och intensivvård0 (SwePub)302012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Anesthesiology and Intensive Care0 (SwePub)302012 hsv//eng
653 a Consciousness and Cognitive Neuroscience
653 a Kognitiv neurovetenskap och filosofi
7001 a Laaksonen, Lauri T.u Department of Peri-operative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland ; Turku PET Centre, University of Turku and Turku University Hospital, Finland4 aut
7001 a Laitio, Timo T.u Department of Peri-operative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland4 aut
7001 a Kallionpää, Roosa E.u Department of Peri-operative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland ; Department of Psychology and Speech-Language Pathology and Turku Brain and Mind Center, University of Turku, Finland4 aut
7001 a Långsjö, Jaakko W.u Department of Intensive Care, Tampere University Hospital, Finland4 aut
7001 a Scheinin, Joonas M.u Department of Peri-operative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland4 aut
7001 a Vahlberg, Tero J.u Department of Clinical Medicine, Biostatistics, University of Turku and Turku University Hospital, Finland4 aut
7001 a Koskela, Harri T.u Nightingale Health Ltd, Helsinki, Finland4 aut
7001 a Aittomäki, Viljamiu Nightingale Health Ltd, Helsinki, Finland4 aut
7001 a Valli, Katja J.,d 1973-u Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Department of Peri-operative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland ; Department of Psychology and Speech-Language Pathology and Turku Brain and Mind Center, University of Turku, Finland,Kognitiv neurovetenskap och filosofi, Consciousness and Cognitive Neuroscience4 aut0 (Swepub:his)vala
7001 a Revonsuo, Anttiu Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Department of Psychology and Speech-Language Pathology and Turku Brain and Mind Center, University of Turku, Finland,Kognitiv neurovetenskap och filosofi, Consciousness and Cognitive Neuroscience4 aut0 (Swepub:his)reva
7001 a Niemi, Mikkou Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Finland ; Individualized Drug Therapy Research Program, Faculty of Medicine, University of Helsinki, Finland4 aut
7001 a Perola, Markusu Finnish Institute for Health and Welfare, Finland ; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Finland4 aut
7001 a Scheinin, Harryu Department of Peri-operative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland ; Turku PET Centre, University of Turku and Turku University Hospital, Finland ; Integrative Physiologyand Pharmacology, Institute of Biomedicine, University of Turku, Finland4 aut
7102 a Department of Peri-operative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland ; Department of Internal Medicine, Turku University Hospital, Finlandb Department of Peri-operative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland ; Turku PET Centre, University of Turku and Turku University Hospital, Finland4 org
7730 t European Journal of Anaesthesiologyd : Wolters Kluwerg 39:6, s. 521-532q 39:6<521-532x 0265-0215x 1365-2346
8564 u https://doi.org/10.1097/EJA.0000000000001591y Fulltext
8564 u https://his.diva-portal.org/smash/get/diva2:1620805/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-20791
8564 8u https://doi.org/10.1097/EJA.0000000000001591

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