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T Regulatory Cells ...
T Regulatory Cells in B-Cell Malignancy : Tumor Support or Kiss of Death?
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- Lindqvist, Camilla A (författare)
- Uppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab
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- Loskog, Angelica Si (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- 2012-03-02
- 2012
- Engelska.
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Ingår i: Immunology. - : Wiley. - 0019-2805 .- 1365-2567. ; 135:4, s. 255-260
- Relaterad länk:
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https://www.ncbi.nlm...
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visa fler...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- It is well established that T regulatory cells (Tregs) counteract tumor immunity. However, conflicting results describing the role of Tregs in hematological tumors warrant further investigations to clarify the interactions between Tregs and the tumor. B-cell malignancy derives from different stages of B-cell development and differentiation in which T-cells play a profound role. The transformed B-cell may still be in need of T-cell help to thrive but simultaneously they may be recognized and destroyed by cytotoxic lymphocytes. Recent reports demonstrate that Tregs can suppress and even kill B-cells as part of their normal function to rescue the body from autoimmunity. An emerging body of evidence points out that Tregs inhibit tumor-specific T-cells but may also have a role in suppressing the progression of the B-cell tumor. In this review, we discuss the origin and function of Tregs and their role in patients with B-cell tumors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- B-cell leukaemia
- B-cell lymphoma
- cytotoxic regulatory cells
- immune regulation
- T regulatory cells
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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