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Prognostic Signific...
Prognostic Significance of Arterial Lactate Levels at Weaning from Postcardiotomy Venoarterial Extracorporeal Membrane Oxygenation
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- Biancari, Fausto (författare)
- University of Oulu,University of Turku
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- Fiore, Antonio (författare)
- University of Paris-Est
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- Jónsson, Kristján (författare)
- Sahlgrenska University Hospital
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- Gatti, Giuseppe (författare)
- University Hospital Of Trieste
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- Zipfel, Svante (författare)
- University Heart & Vascular Center Hamburg
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- Ruggieri, Vito G (författare)
- Robert Debré University Hospital
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- Perrotti, Andrea (författare)
- University Hospital Jean Minjoz
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- Bounader, Karl (författare)
- Pontchaillou University Hospital
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- Loforte, Antonio (författare)
- University of Bologna
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- Lechiancole, Andrea (författare)
- University Hospital of Udine
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- Saeed, Diyar (författare)
- University Hospital of Düsseldorf
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- Lichtenberg, Artur (författare)
- University Hospital of Düsseldorf
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- Pol, Marek (författare)
- Institute for Clinical and Experimental Medicine (IKEM)
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- Spadaccio, Cristiano (författare)
- Golden Jubilee National Hospital
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- Pettinari, Matteo (författare)
- Zhongnan Hospital of Wuhan University
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- Mogianos, Krister (författare)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Forskargrupper vid Lunds universitet,Anaesthesiology and Intensive Care Medicine,Lund University Research Groups
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- Alkhamees, Khalid (författare)
- Prince Sultan Cardiac Center
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- Mariscalco, Giovanni (författare)
- University Hospitals of Leicester NHS Trust
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- El Dean, Zein (författare)
- University Hospitals of Leicester NHS Trust
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- Settembre, Nicla (författare)
- University of Lorraine
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- Welp, Henryk (författare)
- University Hospital Münster
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- Dell'Aquila, Angelo M (författare)
- University Hospital Münster
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- Fux, Thomas (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Juvonen, Tatu (författare)
- Helsinki University of Technology,University of Oulu
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- Dalén, Magnus (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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DellAquila, AM (författare)
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(creator_code:org_t)
- 2019-12-15
- 2019
- Engelska.
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Ingår i: Journal of Clinical Medicine. - : MDPI AG. - 2077-0383. ; 8:12
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.mdpi.com...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
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- BACKGROUND: The outcome after weaning from postcardiotomy venoarterial extracorporeal membrane oxygenation (VA-ECMO) is poor. In this study, we investigated the prognostic impact of arterial lactate levels at the time of weaning from postcardiotomy VA.METHODS: This analysis included 338 patients from the multicenter PC-ECMO registry with available data on arterial lactate levels at weaning from VA-ECMO.RESULTS: Arterial lactate levels at weaning from VA-ECMO (adjusted OR 1.426, 95%CI 1.157-1.758) was an independent predictor of hospital mortality, and its best cutoff values was 1.6 mmol/L (<1.6 mmol/L, 26.2% vs. ≥ 1.6 mmol/L, 45.0%; adjusted OR 2.489, 95%CI 1.374-4.505). When 261 patients with arterial lactate at VA-ECMO weaning ≤2.0 mmol/L were analyzed, a cutoff of arterial lactate of 1.4 mmol/L for prediction of hospital mortality was identified (<1.4 mmol/L, 24.2% vs. ≥1.4 mmol/L, 38.5%, p = 0.014). Among 87 propensity score-matched pairs, hospital mortality was significantly higher in patients with arterial lactate ≥1.4 mmol/L (39.1% vs. 23.0%, p = 0.029) compared to those with lower arterial lactate.CONCLUSIONS: Increased arterial lactate levels at the time of weaning from postcardiotomy VA-ECMO increases significantly the risk of hospital mortality. Arterial lactate may be useful in guiding optimal timing of VA-ECMO weaning.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Biancari, Fausto
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Fiore, Antonio
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Jónsson, Kristjá ...
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Gatti, Giuseppe
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Zipfel, Svante
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Ruggieri, Vito G
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visa fler...
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Perrotti, Andrea
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Bounader, Karl
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Loforte, Antonio
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Lechiancole, And ...
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Saeed, Diyar
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Lichtenberg, Art ...
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Pol, Marek
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Spadaccio, Crist ...
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Pettinari, Matte ...
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Mogianos, Kriste ...
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Alkhamees, Khali ...
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Mariscalco, Giov ...
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El Dean, Zein
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Settembre, Nicla
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Welp, Henryk
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Dell'Aquila, Ang ...
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Fux, Thomas
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Juvonen, Tatu
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Dalén, Magnus
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DellAquila, AM
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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Journal of Clini ...
- Av lärosätet
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Lunds universitet
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Karolinska Institutet