Sökning: WFRF:(Noble William Stafford) >
Assigning significa...
Assigning significance to peptides identified by tandem mass spectrometry using decoy databases
-
- Käll, Lukas, 1969- (författare)
- Department of Genome Sciences, University of Washington, Seattle
-
Storey, John D. (författare)
-
MacCoss, Michael J. (författare)
-
visa fler...
-
Noble, William Stafford (författare)
-
visa färre...
-
(creator_code:org_t)
- 2007-12-08
- 2008
- Engelska.
-
Ingår i: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 7:1, s. 29-34
- Relaterad länk:
-
http://noble.gs.wash...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Automated methods for assigning peptides to observed tandem mass spectra typically return a list of peptide-spectrum matches, ranked according to an arbitrary score. In this article, we describe methods for converting these arbitrary scores into more useful statistical significance measures. These methods employ a decoy sequence database as a model of the null hypothesis, and use false discovery rate (FDR) analysis to correct for multiple testing. We first describe a simple FDR inference method and then describe how estimating and taking into account the percentage of incorrectly identified spectra in the entire data set can lead to increased statistical power.
Ämnesord
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas