WFRF:(Sager T. M.)
Sökning: WFRF:(Sager T. M.) > KLOTHO heterozygosi...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04523naa a2200661 4500 | |
| 001 | oai:gup.ub.gu.se/283343 | |
| 003 | SwePub | |
| 008 | 240528s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2833432 URI |
| 024 | 7 | a https://doi.org/10.1212/wnl.00000000000073232 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Erickson, C. M.4 aut |
| 245 | 1 0 | a KLOTHO heterozygosity attenuates APOE4-related amyloid burden in preclinical AD |
| 264 | c 2019-03-13 | |
| 264 | 1 | b Ovid Technologies (Wolters Kluwer Health),c 2019 |
| 520 | a Objective To examine whether the KLOTHO gene variant KL-VS attenuates APOE4-associated beta-amyloid (A beta) accumulation in a late-middle-aged cohort enriched with Alzheimer disease (AD) risk factors. Three hundred nine late-middle-aged adults from the Wisconsin Registry for Alzheimer's Prevention and the Wisconsin Alzheimer's Disease Research Center were genotyped to determine KL-VS and APOE4 status and underwent CSF sampling (n = 238) and/or 11C-Pittsburgh compound B (PiB)-PET imaging (n = 183). Covariate-adjusted regression analyses were used to investigate whether APOE4 exerted expected effects on A beta burden. Follow-up regression analyses stratified by KL-VS genotype (i.e., noncarrier vs heterozygous; there were no homozygous individuals) evaluated whether the influence of APOE4 on A beta was different among KL-VS heterozygotes compared to noncarriers. APOE4 carriers exhibited greater A beta burden than APOE4-negative participants. This effect was stronger in CSF (t = -5.12, p < 0.001) compared with PiB-PET (t = 3.93, p < 0.001). In the stratified analyses, this APOE4 effect on A beta load was recapitulated among KL-VS noncarriers (CSF: t = -5.09, p < 0.001; PiB-PET: t = 3.77, p < 0.001). In contrast, among KL-VS heterozygotes, APOE4-positive individuals did not exhibit higher A beta burden than APOE4-negative individuals (CSF: t = -1.03, p = 0.308; PiB-PET: t = 0.92, p = 0.363). These differential APOE4 effects remained after KL-VS heterozygotes and noncarriers were matched on age and sex. In a cohort of at-risk late-middle-aged adults, KL-VS heterozygosity was associated with an abatement of APOE4-associated A beta aggregation, suggesting KL-VS heterozygosity confers protections against APOE4-linked pathways to disease onset in AD. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 653 | a apolipoprotein-e | |
| 653 | a alzheimers-disease | |
| 653 | a functional variant | |
| 653 | a cognitive | |
| 653 | a decline | |
| 653 | a epsilon-4 allele | |
| 653 | a beta | |
| 653 | a association | |
| 653 | a gene | |
| 653 | a risk | |
| 653 | a apoe | |
| 653 | a Neurosciences & Neurology | |
| 700 | 1 | a Schultz, S. A.4 aut |
| 700 | 1 | a Oh, J. M.4 aut |
| 700 | 1 | a Darst, B. F.4 aut |
| 700 | 1 | a Ma, Y.4 aut |
| 700 | 1 | a Norton, D.4 aut |
| 700 | 1 | a Betthauser, T.4 aut |
| 700 | 1 | a Gallagher, C. L.4 aut |
| 700 | 1 | a Carlsson, C. M.4 aut |
| 700 | 1 | a Bendlin, B. B.4 aut |
| 700 | 1 | a Asthana, S.4 aut |
| 700 | 1 | a Hermann, B. P.4 aut |
| 700 | 1 | a Sager, M. A.4 aut |
| 700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
| 700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
| 700 | 1 | a Engelman, C. D.4 aut |
| 700 | 1 | a Christian, B. T.4 aut |
| 700 | 1 | a Johnson, S. C.4 aut |
| 700 | 1 | a Dubal, D. B.4 aut |
| 700 | 1 | a Okonkwo, O. C.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
| 773 | 0 | t Neurologyd : Ovid Technologies (Wolters Kluwer Health)g 92:16q 92:16x 0028-3878x 1526-632X |
| 856 | 4 | u https://europepmc.org/articles/pmc6550504?pdf=render |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/283343 |
| 856 | 4 8 | u https://doi.org/10.1212/wnl.0000000000007323 |
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- Oh, J. M.
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- Ma, Y.
- Norton, D.
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- Betthauser, T.
- Gallagher, C. L.
- Carlsson, C. M.
- Bendlin, B. B.
- Asthana, S.
- Hermann, B. P.
- Sager, M. A.
- Blennow, Kaj, 19 ...
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- Christian, B. T.
- Johnson, S. C.
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