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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 19142naa a2202941 4500 | |
| 001 | oai:gup.ub.gu.se/252115 | |
| 003 | SwePub | |
| 008 | 240528s2013 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:5d7dd921-304d-4c2f-90ef-5aabe0e822f8 | |
| 009 | oai:prod.swepub.kib.ki.se:127684109 | |
| 009 | oai:DiVA.org:liu-102079 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2521152 URI |
| 024 | 7 | a https://doi.org/10.1038/ng.27702 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/42051092 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1276841092 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1020792 URI |
| 040 | a (SwePub)gud (SwePub)lud (SwePub)kid (SwePub)liu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Beecham, Ashley Hu Karolinska Institutet,University of Miami, FL USA,Childrens Hospital Philadelphia, PA USA4 aut |
| 245 | 1 0 | a Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. |
| 264 | c 2013-09-29 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2013 |
| 500 | a Funding Agencies|US National Institutes of Health||Wellcome Trust||UK MS Society||UK Medical Research Council||US National MS Society||Cambridge National Institute for Health Research (NIHR) Biomedical Research Centre||DeNDRon||Swedish Brain Foundation||Swedish Research Council||Knut and Alice Wallenberg Foundation||Swedish Heart-Lung Foundation||Foundation for Strategic Research|| | |
| 520 | a Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 1.0 × 10(-4)). In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802 subjects with multiple sclerosis and 26,703 healthy controls. In these 80,094 individuals of European ancestry, we identified 48 new susceptibility variants (P < 5.0 × 10(-8)), 3 of which we found after conditioning on previously identified variants. Thus, there are now 110 established multiple sclerosis risk variants at 103 discrete loci outside of the major histocompatibility complex. With high-resolution Bayesian fine mapping, we identified five regions where one variant accounted for more than 50% of the posterior probability of association. This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 653 | a Chromosome Mapping | |
| 653 | a European Continental Ancestry Group | |
| 653 | a genetics | |
| 653 | a Gene Frequency | |
| 653 | a Genetic Loci | |
| 653 | a Genetic Predisposition to Disease | |
| 653 | a Genetic Variation | |
| 653 | a Genome-Wide Association Study | |
| 653 | a Genotype | |
| 653 | a Humans | |
| 653 | a Multiple Sclerosis | |
| 653 | a genetics | |
| 653 | a immunology | |
| 653 | a Polymorphism | |
| 653 | a Single Nucleotide | |
| 653 | a TECHNOLOGY | |
| 700 | 1 | a Patsopoulos, Nikolaos Au Brigham and Womens Hospital, MA USA4 aut |
| 700 | 1 | a Xifara, Dionysia Ku University of Oxford, England,Seinajoki Central Hospital, Finland4 aut |
| 700 | 1 | a Davis, Mary Fu Vanderbilt University, TN USA4 aut |
| 700 | 1 | a Kemppinen, Anuu University of Cambridge, England4 aut |
| 700 | 1 | a Cotsapas, Chrisu Broad Institute Harvard and MIT, MA USA,University of Medical Centre Hamburg Eppendorf, Germany,University of Calif San Francisco, CA USA,Vanderbilt University, TN USA,Technical University of Munich, Germany4 aut |
| 700 | 1 | a Shah, Tejas Su Wellcome Trust Sanger Institute, England,Royal Preston Hospital, England,Norfolk and Norwich Hospital, England4 aut |
| 700 | 1 | a Spencer, Chrisu University of Oxford, England4 aut |
| 700 | 1 | a Booth, Davidu University of Sydney, Australia4 aut |
| 700 | 1 | a Goris, Anu Katholieke University of Leuven, Belgium4 aut |
| 700 | 1 | a Oturai, Annetteu Copenhagen University Hospital, Denmark4 aut |
| 700 | 1 | a Saarela, Jannau University of Helsinki, Finland4 aut |
| 700 | 1 | a Fontaine, Bertrandu University of Paris 06, France4 aut |
| 700 | 1 | a Hemmer, Bernhardu Technical University of Munich, Germany4 aut |
| 700 | 1 | a Martin, Claesu Danderyd Hospital, Sweden4 aut |
| 700 | 1 | a Zipp, Fraukeu Johannes Gutenberg University of Mainz, Germany4 aut |
| 700 | 1 | a D'Alfonso, Sandrau University of Piemonte Orientale, Italy4 aut |
| 700 | 1 | a Martinelli-Boneschi, Filippou Ist Science San Raffaele, Italy4 aut |
| 700 | 1 | a Taylor, Bruceu University of Tasmania, Australia4 aut |
| 700 | 1 | a Harbo, Hanne Fu Oslo University Hospital, Norway4 aut |
| 700 | 1 | a Kockum, Ingridu Karolinska Institutet,Karolinska Institute, Sweden4 aut |
| 700 | 1 | a Hillert, Janu Karolinska Institutet,Karolinska Institute, Sweden4 aut |
| 700 | 1 | a Olsson, Tomasu Karolinska Institutet,Karolinska Institute, Sweden4 aut |
| 700 | 1 | a Ban, Mariau University of Cambridge, England4 aut |
| 700 | 1 | a Oksenberg, Jorge Ru University of Calif San Francisco, CA USA4 aut |
| 700 | 1 | a Hintzen, Rogieru Erasmus University, Netherlands4 aut |
| 700 | 1 | a Barcellos, Lisa Fu University of Calif Berkeley, CA 94720 USA4 aut |
| 700 | 1 | a Agliardi, Cristinau IRCCS Santa Maria Nascente, Italy4 aut |
| 700 | 1 | a Alfredsson, Larsu Karolinska Institutet,Karolinska Institute, Sweden4 aut |
| 700 | 1 | a Alizadeh, Mehdiu University of Rennes 1, France,University of Aberdeen, Scotland4 aut |
| 700 | 1 | a Anderson, Carlu Wellcome Trust Sanger Institute, England4 aut |
| 700 | 1 | a Andrews, Robertu Wellcome Trust Sanger Institute, England4 aut |
| 700 | 1 | a Søndergaard, Helle Bachu Copenhagen University Hospital, Denmark4 aut |
| 700 | 1 | a Baker, Amieu University of Cambridge, England4 aut |
| 700 | 1 | a Band, Gavinu University of Oxford, England4 aut |
| 700 | 1 | a Baranzini, Sergio Eu University of Calif San Francisco, CA USA4 aut |
| 700 | 1 | a Barizzone, Nadiau University of Piemonte Orientale, Italy4 aut |
| 700 | 1 | a Barrett, Jeffreyu Wellcome Trust Sanger Institute, England4 aut |
| 700 | 1 | a Bellenguez, Célineu University of Oxford, England4 aut |
| 700 | 1 | a Bergamaschi, Laurau University of Piemonte Orientale, Italy4 aut |
| 700 | 1 | a Bernardinelli, Luisau MRC, England4 aut |
| 700 | 1 | a Berthele, Achimu Technical University of Munich, Germany4 aut |
| 700 | 1 | a Biberacher, Violau Technical University of Munich, Germany4 aut |
| 700 | 1 | a Binder, Thomas M Cu Karolinska Institutet,Karolinska Institute, Sweden,Broad Institute Harvard and MIT, MA USA4 aut |
| 700 | 1 | a Blackburn, Hannahu Wellcome Trust Sanger Institute, England4 aut |
| 700 | 1 | a Bomfim, Izaura Lu Karolinska Institutet,Karolinska Institute, Sweden4 aut |
| 700 | 1 | a Brambilla, Paolau Ist Science San Raffaele, Italy4 aut |
| 700 | 1 | a Broadley, Simonu Griffith University, Australia4 aut |
| 700 | 1 | a Brochet, Brunou University of Bordeaux 2, France4 aut |
| 700 | 1 | a Brundin, Louu Karolinska Institutet,Karolinska Institute, Sweden4 aut |
| 700 | 1 | a Buck, Dorotheau Technical University of Munich, Germany4 aut |
| 700 | 1 | a Butzkueven, Helmutu University of Melbourne, Australia4 aut |
| 700 | 1 | a Caillier, Stacy Ju University of Calif San Francisco, CA USA4 aut |
| 700 | 1 | a Camu, Williamu Centre Hospital University of Regional Montpellier, France4 aut |
| 700 | 1 | a Carpentier, Wassilau University of Paris 06, France4 aut |
| 700 | 1 | a Cavalla, Paolau Azienda Osped Citta Salute and Science Torino, Italy4 aut |
| 700 | 1 | a Celius, Elisabeth Gu Oslo University Hospital, Norway4 aut |
| 700 | 1 | a Coman, Irèneu Hop Avicenne, France4 aut |
| 700 | 1 | a Comi, Giancarlou Ist Science San Raffaele, Italy4 aut |
| 700 | 1 | a Corrado, Luciau University of Piemonte Orientale, Italy4 aut |
| 700 | 1 | a Cosemans, Leentjeu Katholieke University of Leuven, Belgium4 aut |
| 700 | 1 | a Cournu-Rebeix, Isabelleu University of Paris 06, France4 aut |
| 700 | 1 | a Cree, Bruce A Cu University of Cambridge, England4 aut |
| 700 | 1 | a Cusi, Danieleu University of Milan, Italy4 aut |
| 700 | 1 | a Damotte, Vincentu University of Paris 06, France4 aut |
| 700 | 1 | a Defer, Gillesu CHU Caen, France4 aut |
| 700 | 1 | a Delgado, Silvia Ru University of Miami, FL USA4 aut |
| 700 | 1 | a Deloukas, Panosu Wellcome Trust Sanger Institute, England4 aut |
| 700 | 1 | a di Sapio, Alessiau University of San Luigi, Italy4 aut |
| 700 | 1 | a Dilthey, Alexander Tu University of Oxford, England4 aut |
| 700 | 1 | a Donnelly, Peteru University of Oxford, England4 aut |
| 700 | 1 | a Dubois, Bénédicteu Katholieke University of Leuven, Belgium4 aut |
| 700 | 1 | a Duddy, Martinu Royal Victoria Infirm, England4 aut |
| 700 | 1 | a Edkins, Sarahu Wellcome Trust Sanger Institute, England4 aut |
| 700 | 1 | a Elovaara, Irinau University of Tampere, Finland4 aut |
| 700 | 1 | a Esposito, Federicau Ist Science San Raffaele, Italy4 aut |
| 700 | 1 | a Evangelou, Nikosu University of Nottingham Hospital, England4 aut |
| 700 | 1 | a Fiddes, Barnabyu University of Cambridge, England4 aut |
| 700 | 1 | a Field, Judithu University of Melbourne, Australia4 aut |
| 700 | 1 | a Franke, Andreu University of Kiel, Germany4 aut |
| 700 | 1 | a Freeman, Colinu University of Oxford, England4 aut |
| 700 | 1 | a Frohlich, Irene Yu Brigham and Womens Hospital, MA USA4 aut |
| 700 | 1 | a Galimberti, Danielau University of Milan, Italy4 aut |
| 700 | 1 | a Gieger, Christianu German Research Centre Environm Heatlh, Germany4 aut |
| 700 | 1 | a Gourraud, Pierre-Antoineu University of Calif San Francisco, CA USA4 aut |
| 700 | 1 | a Graetz, Christianeu Johannes Gutenberg University of Mainz, Germany4 aut |
| 700 | 1 | a Graham, Andrewu Ipswich Hospital National Health Serv NHS Trust, England4 aut |
| 700 | 1 | a Grummel, Verenau Technical University of Munich, Germany4 aut |
| 700 | 1 | a Guaschino, Clarau Ist Science San Raffaele, Italy4 aut |
| 700 | 1 | a Hadjixenofontos, Athenau University of Miami, FL USA4 aut |
| 700 | 1 | a Hakonarson, Hakonu Karolinska Institutet,Brigham and Womens Hospital, MA USA4 aut |
| 700 | 1 | a Halfpenny, Christopheru Southampton Gen Hospital, England4 aut |
| 700 | 1 | a Hall, Gillianu Aberdeen Royal Infirm, Scotland4 aut |
| 700 | 1 | a Hall, Peru Karolinska Institutet,Karolinska Institute, Sweden4 aut |
| 700 | 1 | a Hamsten, Andersu Karolinska University Hospital Solna, Sweden4 aut |
| 700 | 1 | a Harley, Jamesu Hull Royal Infirm, England4 aut |
| 700 | 1 | a Harrower, Timothyu Royal Devon and Exeter Fdn Trust Hospital, England4 aut |
| 700 | 1 | a Hawkins, Cliveu Keele University, England4 aut |
| 700 | 1 | a Hellenthal, Garrettu UCL, England4 aut |
| 700 | 1 | a Hillier, Charlesu Poole Gen Hospital, England4 aut |
| 700 | 1 | a Hobart, Jeremyu University of Plymouth, England4 aut |
| 700 | 1 | a Hoshi, Muniu Technical University of Munich, Germany4 aut |
| 700 | 1 | a Hunt, Sarah E4 aut |
| 700 | 1 | a Jagodic, Majau Karolinska Institutet,Karolinska Institute, Sweden4 aut |
| 700 | 1 | a Jelčić, Ilijasu University of Medical Centre Hamburg Eppendorf, Germany4 aut |
| 700 | 1 | a Jochim, Angelau Technical University of Munich, Germany4 aut |
| 700 | 1 | a Kendall, Brianu Leicester Royal Infirm, England4 aut |
| 700 | 1 | a Kermode, Allanu University of Western Australia, Australia4 aut |
| 700 | 1 | a Kilpatrick, Trevoru University of Melbourne, Australia4 aut |
| 700 | 1 | a Koivisto, Keijo4 aut |
| 700 | 1 | a Konidari, Ioannau University of Miami, FL USA4 aut |
| 700 | 1 | a Korn, Thomasu Technical University of Munich, Germany4 aut |
| 700 | 1 | a Kronsbein, Helenau Technical University of Munich, Germany4 aut |
| 700 | 1 | a Langford, Cordeliau Wellcome Trust Sanger Institute, England4 aut |
| 700 | 1 | a Larsson, Malinu Linköpings universitet,Bioinformatik,Tekniska högskolan4 aut0 (Swepub:liu)malla74 |
| 700 | 1 | a Lathrop, Marku Centre Etud Polymorphisme Humain, France4 aut |
| 700 | 1 | a Lebrun-Frenay, Christineu CHRU Nice, France4 aut |
| 700 | 1 | a Lechner-Scott, Jeannetteu University of Newcastle, Australia4 aut |
| 700 | 1 | a Lee, Michelle H4 aut |
| 700 | 1 | a Leone, Maurizio Au Osped Maggiore Novara, Italy4 aut |
| 700 | 1 | a Leppä, Virpiu University of Helsinki, Finland4 aut |
| 700 | 1 | a Liberatore, Giuseppeu Ist Science San Raffaele, Italy4 aut |
| 700 | 1 | a Lie, Benedicte Au University of Oslo, Norway4 aut |
| 700 | 1 | a Lill, Christina Mu Johannes Gutenberg University of Mainz, Germany4 aut |
| 700 | 1 | a Lindén, Magdalena4 aut |
| 700 | 1 | a Link, Jennyu Karolinska Institutet,Karolinska Institute, Sweden4 aut |
| 700 | 1 | a Luessi, Felixu Johannes Gutenberg University of Mainz, Germany4 aut |
| 700 | 1 | a Lycke, Jan,d 1956u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,University of Gothenburg, Sweden4 aut0 (Swepub:gu)xlycja |
| 700 | 1 | a Macciardi, Fabiou University of Calif Irvine, CA USA4 aut |
| 700 | 1 | a Männistö, Satuu National Institute Health and Welf, Finland4 aut |
| 700 | 1 | a Manrique, Clara Pu University of Miami, FL USA4 aut |
| 700 | 1 | a Martin, Rolandu University of Medical Centre Hamburg Eppendorf, Germany4 aut |
| 700 | 1 | a Martinelli, Vittoriou Ist Science San Raffaele, Italy4 aut |
| 700 | 1 | a Mason, Deborahu Canterbury Dist Health Board, New Zealand4 aut |
| 700 | 1 | a Mazibrada, Gordonu Queen Elizabeth Medical Centre, England4 aut |
| 700 | 1 | a McCabe, Cristin4 aut |
| 700 | 1 | a Mero, Inger-Liseu Oslo University Hospital, Norway4 aut |
| 700 | 1 | a Mescheriakova, Juliau Erasmus University, Netherlands4 aut |
| 700 | 1 | a Moutsianas, Loukasu University of Oxford, England4 aut |
| 700 | 1 | a Myhr, Kjell-Mortenu Haukeland Hospital, Norway4 aut |
| 700 | 1 | a Nagels, Guyu National Multiple Sclerosis Centre Melsbroek, Belgium4 aut |
| 700 | 1 | a Nicholas, Richardu Charing Cross Hospital, England4 aut |
| 700 | 1 | a Nilsson, Petrau Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden4 aut0 (Swepub:lu)neur-pn8 |
| 700 | 1 | a Piehl, Fredriku Karolinska Institutet,Karolinska Institute, Sweden4 aut |
| 700 | 1 | a Pirinen, Mattiu University of Oxford, England4 aut |
| 700 | 1 | a Price, Siân Eu Royal Hallamshire Hospital, England4 aut |
| 700 | 1 | a Quach, Hongu University of Calif Berkeley, CA USA4 aut |
| 700 | 1 | a Reunanen, Mauriu University of Oulu, Finland4 aut |
| 700 | 1 | a Robberecht, Wimu Vesalius Research Centre, Belgium4 aut |
| 700 | 1 | a Robertson, Neil Pu Cardiff University, Wales4 aut |
| 700 | 1 | a Rodegher, Mariaemmau Ist Science San Raffaele, Italy4 aut |
| 700 | 1 | a Rog, Davidu Salford Royal NHS Fdn Trust, England4 aut |
| 700 | 1 | a Salvetti, Marcou University of Roma La Sapienza, Italy4 aut |
| 700 | 1 | a Schnetz-Boutaud, Nathalie C4 aut |
| 700 | 1 | a Sellebjerg, Finnu Copenhagen University Hospital, Denmark4 aut |
| 700 | 1 | a Selter, Rebecca C4 aut |
| 700 | 1 | a Schaefer, Catherineu Kaiser Permanente Div Research, CA USA4 aut |
| 700 | 1 | a Shaunak, Sandipu University of Melbourne, Australia4 aut |
| 700 | 1 | a Shen, Lingu Kaiser Permanente Div Research, CA USA4 aut |
| 700 | 1 | a Shields, Simon4 aut |
| 700 | 1 | a Siffrin, Volkeru Johannes Gutenberg University of Mainz, Germany4 aut |
| 700 | 1 | a Slee, Marku Flinders University of S Australia, Australia4 aut |
| 700 | 1 | a Sorensen, Per Soelbergu Copenhagen University Hospital, Denmark4 aut |
| 700 | 1 | a Sorosina, Melissau Ist Science San Raffaele, Italy4 aut |
| 700 | 1 | a Sospedra, Mireiau University of Medical Centre Hamburg Eppendorf, Germany4 aut |
| 700 | 1 | a Spurkland, Anneu University of Oslo, Norway4 aut |
| 700 | 1 | a Strange, Amyu University of Oxford, England4 aut |
| 700 | 1 | a Sundqvist, Emilieu Karolinska Institute, Sweden4 aut |
| 700 | 1 | a Thijs, Vincentu Vesalius Research Centre, Belgium4 aut |
| 700 | 1 | a Thorpe, Johnu Peterborough City Hospital, England4 aut |
| 700 | 1 | a Ticca, Annau San Francesco Hospital, Italy4 aut |
| 700 | 1 | a Tienari, Penttiu University of Helsinki, Finland4 aut |
| 700 | 1 | a van Duijn, Corneliau Erasmus MC, Netherlands4 aut |
| 700 | 1 | a Visser, Elizabeth M4 aut |
| 700 | 1 | a Vucic, Steveu University of Sydney, Australia4 aut |
| 700 | 1 | a Westerlind, Helgau Karolinska Institute, Sweden4 aut |
| 700 | 1 | a Wiley, James S4 aut |
| 700 | 1 | a Wilkins, Alastairu University of Bristol, England4 aut |
| 700 | 1 | a Wilson, James Fu University of Edinburgh, Scotland4 aut |
| 700 | 1 | a Winkelmann, Julianeu Technical University of Munich, Germany4 aut |
| 700 | 1 | a Zajicek, Johnu University of Plymouth, England4 aut |
| 700 | 1 | a Zindler, Evau Johannes Gutenberg University of Mainz, Germany4 aut |
| 700 | 1 | a Haines, Jonathan Lu Vanderbilt University, TN USA4 aut |
| 700 | 1 | a Pericak-Vance, Margaret Au University of Miami, FL USA4 aut |
| 700 | 1 | a Ivinson, Adrian Ju Harvard University, MA USA4 aut |
| 700 | 1 | a Stewart, Graemeu University of Sydney, Australia4 aut |
| 700 | 1 | a Hafler, Davidu Broad Institute Harvard and MIT, MA USA4 aut |
| 700 | 1 | a Hauser, Stephen Lu University of Calif San Francisco, CA USA4 aut |
| 700 | 1 | a Compston, Alastair4 aut |
| 700 | 1 | a McVean, Gilu University of Oxford, England4 aut |
| 700 | 1 | a De Jager, Philipu Brigham and Womens Hospital, MA USA4 aut |
| 700 | 1 | a Sawcer, Stephen Ju University of Cambridge, England4 aut |
| 700 | 1 | a McCauley, Jacob Lu University of Miami, FL USA4 aut |
| 710 | 2 | a Karolinska Institutetb University of Miami, FL USA4 org |
| 773 | 0 | t Nature geneticsd : Springer Science and Business Media LLCg 45:11, s. 1353-60q 45:11<1353-60x 1546-1718x 1061-4036 |
| 856 | 4 | u https://europepmc.org/articles/pmc3832895?pdf=render |
| 856 | 4 | u http://dx.doi.org/10.1038/ng.2770y FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/252115 |
| 856 | 4 8 | u https://doi.org/10.1038/ng.2770 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/4205109 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:127684109 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-102079 |
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