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Acute hyperoxaemia-...
Acute hyperoxaemia-induced effects on regional blood flow, oxygen consumption and central circulation in man
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- Rousseau, Andreas, 1971- (författare)
- Linköpings universitet,Anestesiologi med intensivvård,Hälsouniversitetet
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- Bak, Zoltan, 1950- (författare)
- Linköpings universitet,Anestesiologi med intensivvård,Hälsouniversitetet
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- Janerot-Sjöberg, Birgitta, 1958- (författare)
- Linköpings universitet,Klinisk fysiologi,Hälsouniversitetet,Department of Clinical Physiology, Heart Centre, University Hospital, Linköping, Sweden
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- Sjöberg, Folke, 1956- (författare)
- Linköpings universitet,Anestesiologi med intensivvård,Hälsouniversitetet
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(creator_code:org_t)
- 2005
- 2005
- Engelska.
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Ingår i: Acta Physiologica Scandinavica. - 0001-6772 .- 1365-201X. ; 183:3, s. 231-240
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Aim: Despite numerous in vitro and animal studies, circulatory effects and mechanisms responsible for the vasoconstriction seen during hyperoxaemia are yet to be ascertained. The present study set out to: (i) set up a non-invasive human model for the study of hyperoxia-induced cardiovascular effects, (ii) describe the dynamics of this effect and (iii) determine whether hyperoxaemia also, by vasoconstriction alters oxygen consumption (O2).Methods: The study comprised four experiments (A, B, C and D) on healthy volunteers examined before, during and after 100% oxygen breathing. A: Blood flow (mL min−1·100 mL−1 tissue), venous occlusion plethysmography was assessed (n = 12). B: Blood flow was recorded with increasing transcutaneous oxygen tension (PtcO2) levels (dose–response) (n = 8). C: Heart rate (HR), stroke volume, cardiac output (CO) and systemic vascular resistance (SVR) was assessed using echocardiography (n = 8). D: O2 was measured using an open circuit technique when breathing an air-O2 mix (fraction of inhaled oxygen: FiO2 = 0.58) (n = 8).Results: Calf blood flow decreased 30% during O2 breathing. The decrease in calf blood flow was found to be oxygen dose dependent. A similar magnitude, as for the peripheral circulation, of the effect on central parameters (HR/CO and SVR) and in the time relationship was noted. Hyperoxia did not change O2. An average of 207 (93) mL O2 per subject was washed in during the experiments.Conclusion: This model appears suitable for the investigation of O2-related effects on the central and peripheral circulation in man. Our findings, based on a more comprehensive (central/peripheral circulation examination) evaluation than earlier made, suggest significant circulatory effects of hyperoxia. Further studies are warranted to elucidate the underlying mechanisms.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- blood flow
- consumption
- hyperoxaemia
- hyperoxia
- oxygen
- vasoconstriction
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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