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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005051naa a2200541 4500
001oai:DiVA.org:umu-110913
003SwePub
008151029s2015 | |||||||||||000 ||eng|
009oai:DiVA.org:kth-161632
009oai:DiVA.org:uu-239503
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1109132 URI
0247 a https://doi.org/10.1007/s00535-014-0958-72 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-1616322 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2395032 URI
040 a (SwePub)umud (SwePub)kthd (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Gremel, Gabrielau Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)gabgr787
2451 0a The human gastrointestinal tract-specific transcriptome and proteome as defined by RNA sequencing and antibody-based profiling
264 c 2014-05-01
264 1b Springer,c 2015
338 a print2 rdacarrier
500 a First online: 01 May 2014
500 a QC 20150324
520 a BACKGROUND: The gastrointestinal tract (GIT) is subdivided into different anatomical organs with many shared functions and characteristics, but also distinct differences. We have combined a genome-wide transcriptomics analysis with immunohistochemistry-based protein profiling to describe the gene and protein expression patterns that define the human GIT. METHODS: RNA sequencing data derived from stomach, duodenum, jejunum/ileum and colon specimens were compared to gene expression levels in 23 other normal human tissues analysed with the same method. Protein profiling based on immunohistochemistry and tissue microarrays was used to sub-localize the corresponding proteins with GIT-specific expression into sub-cellular compartments and cell types. RESULTS: Approximately 75% of all human protein-coding genes were expressed in at least one of the GIT tissues. Only 51 genes showed enriched expression in either one of the GIT tissues and an additional 83 genes were enriched in two or more GIT tissues. The list of GIT-enriched genes with validated protein expression patterns included various well-known but also previously uncharacterised or poorly studied genes. For instance, the colon-enriched expression of NXPE family member 1 (NXPE1) was established, while NLR family, pyrin domain-containing 6 (NLRP6) expression was primarily found in the human small intestine. CONCLUSIONS: We have applied a genome-wide analysis based on transcriptomics and antibody-based protein profiling to identify genes that are expressed in a specific manner within the human GIT. These genes and proteins constitute important starting points for an improved understanding of the normal function and the different states of disease associated with the GIT.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaper0 (SwePub)3012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicine0 (SwePub)3012 hsv//eng
653 a RNA expression
653 a Immunohistochemistry
653 a Gastrointestinal tract
7001 a Wanders, Alkwinu Uppsala universitet,Molekylär och morfologisk patologi4 aut0 (Swepub:uu)alkwwand
7001 a Cedernaes, Jonathanu Uppsala universitet,Funktionell farmakologi4 aut0 (Swepub:uu)jonce840
7001 a Fagerberg, Linnu KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1dglfid
7001 a Hallström, Björnu KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1ih19oh
7001 a Edlund, Karolinau Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)kaedl086
7001 a Sjöstedt, Evelinau Uppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)evesj711
7001 a Uhlén, Mathiasu KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1dulvmw
7001 a Pontén, Fredriku Uppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)fredpont
7102 a Uppsala universitetb Institutionen för immunologi, genetik och patologi4 org
7730 t Journal of gastroenterologyd : Springerg 50:1, s. 46-57q 50:1<46-57x 0944-1174x 1435-5922
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-110913
8564 8u https://doi.org/10.1007/s00535-014-0958-7
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-161632
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-239503

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